Calcimycin from MedChemExpress

Product Specs
ItemCalcimycin
CompanyMedChemExpress
Price $256.00Supplier Page View Company Product Page
Catalog NumberHY-N6687
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.12%
TypeChemical
Molecular Weight523.62
FormulaC₂₉H₃₇N₃O₆
Research AreaInfection; Cancer

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(1) In Silico Prediction of EZHIP Post-Translational Modification Sites and Small-Molecule High-Throughput Screening for Quantitative EZHIP ModulationBrain Tumor Res TreatApril 30, 2026Jimin Moon, Jiwon Hwang, Chan ChungµM [21], Recilisib (MCE, HY-101625); 10 µM [22], Ionomycin (MCE, HY-13434); 1 µM [23], A23187 (MCE, HY-N6687); 1 µM [24], Spermine (MCE, HY-B1777); 200 µM [25], Anisomycin (MCE, HY-18982); 5 µM [26], Forskolin

(2) Agonal cell resuscitation strategy to promote tissue repairNature CommunicationsApril 11, 2026Zhenxiang Huang, Qingqing Wang, Yiyu Chen, Jiahao Zhu, Jiachen Xu, Yang Yang, Yongcheng Wang, Ke Yang, Huige Yan, Mobai Li, et al.centrifugation were resuspended in PBS containing 2 mM CaCl2 (Solarbio, C7250). Then, 2 μM calcimycin (MCE, HY-N6687) was added, and the mixture was incubated on a shaker at 37 °C for 1 h. Afterwards, the sample was centrifuged

(3) ELAPOR1 regulates VPS54-mediated GARP complex formation and proacrosomal vesicle fusion during spermatogenesisTheranosticsMarch 25, 2026Chen Ding, Tingting Liang, Mina Yang, Lingbin Wang, Xuying Yin, Guoming Li, Zhaoxiang Wang, Jiahui Guo, Lin Zhang, Jie Yang, et al.medium (2 h, 37 °C). Capacitated sperm were then incubated with the calcium ionophore A23187 (10 μM; HY-N6687, MedChemExpress, USA) at 37 °C for 30 min to induce the acrosome reaction. After being air-dried and

(4) LL-37 selectively targets Plasmodium-infected erythrocytes and exhibits antimalarial activityPLoS PathogMarch 17, 2026Xiaoqin He, Yutong Zhang, Junchao Lou, Jingyao Wu, Sui Xu, Guoding Zhu, Jianxia Tang, Yaqun Fang, Jun Caodepletion. PS externalization was induced by incubating erythrocytes with calcium ionophore A23187 (MCE, HY-N6687) (0.125, 0.25, 0.5, 0.75 and 1 μM) in PBS containing 1 μM CaCl₂ for 3 h at 37°C [33]. Cholesterol depletion

(5) Activation of WNK1 signaling through Piezo1Proceedings of the National Academy of Sciences of the United States of AmericaSeptember 2, 2025Jung JU, Stippec S, Cobb MH.(14025092) and without Ca2+/Mg2+ (14175095) were purchased from Thermo Fisher Scientific. Calcimycin (HY-N6687), BAPTA-AM (HY-100545), and thapsigargin (HY-13433) were obtained from MedChemExpress (Monmouth Junction,

(6) Energy stress-induced PKCζ S-glutathionylation is essential for LKB1 cytoplasmic translocation and AMPK activationLife MetabolismJuly 16, 2025Junjie Fei, Shuhan Yu, Mingzhe Xu, Yang Liu, Guoqiang Wang, Xueqing Li, Xinyue Yu, Yifan Zhang, Wenhua Zhang, Yang Wang, et al.Vitamin E (S0079) and glutathione (GSH, S0073) were purchased from Beyotime (Shanghai, China). A-23187(HY-N6687) was purchased from MCE (Shanghai, China). Plasmid transfection, lentiviral infection, and RNA interference Cells

(7) TRPM2 channels mediate ROS-induced actin remodeling and cell migration of prostate cancer cellsBMC CancerMay 28, 2025Pengwei Qi, Jingting Zhao, Hongtian Zhang, Xingyu Liu, Qing You, Jianguo Niu, Xiangming Ye, Fangfang Li(HY-10882), BAPTA-AM (HY-100545), TPEN (HY-100202), Econazole (HY-B0885), Zinc Pyrithione (HY-B0572), A23187 (HY-N6687), CASIN (HY-12874), NSC 23766 (HY-15723) were from MedChemExpress. As palmitic acid is insoluble in

(8) Gasdermin D deficiency aborts myeloid calcium influx to drive granulopoiesis in lupus nephritisCell Communication and SignalingJune 3, 2024Jiani Shen, Feng Li, Xu Han, Dongying Fu, Yiping Xu, Changjian Zhu, Zhou Liang, Ziwen Tang, Ruilin Zheng, Xinrong Hu, et al.or µ-slide 8 well chamber slide (Ibidi, Cat#80,826) and then stimulated with A23187 (5 uM, MCE, Cat#HY-N6687) or vehicle for 3–4 h under 37℃. CitH3 (Abcam, Cat#ab5103) was used to quantify NETs formation according

(9) TBC1D23 mediates Golgi-specific LKB1 signalingNature CommunicationsFebruary 27, 2024Yingfeng Tu, Qin Yang, Min Tang, Li Gao, Yuanhao Wang, Jiuqiang Wang, Zhe Liu, Xiaoyu Li, Lejiao Mao, Rui zhen Jia, et al.free) (Gibco, 11966-025), EBSS (Sigma, E2888), Metformin (Selleck), AICAR (MCE, HY-13417), A23187 (MCE, HY-N6687), Glutathione Beads (Smart-Lifesciences, SA008100), ANTI-FLAG Affinity Gel (Bimake, B23102), GFP beads

(10) Novel ACTL7A variants in males lead to fertilization failure and male infertilityAndrologyNovember 22, 2023Meng Wang, Juepu Zhou, Rui Long, Huizi Jin, Limin Gao, Lixia Zhu, Lei Jin(AOA), the oocytes injected with spermatozoa were exposed to pre‐equilibrated calcium ionophore A23187 (HY‐N6687, MCE) for 15 min after ICSI, 23 and then washed and transferred to G1‐plus medium for culture. 2.8

(11) mmu-lncRNA 121686/hsa-lncRNA 520657 induced by METTL3 drive the progression of AKI by targeting miR-328-5p/HtrA3 signaling axisMolecular therapy : the journal of the American Society of Gene TherapyDecember 7, 2022Pan J, Xie Y, Li H, Li X, Chen J, Liu X, Zhou J, Tang X, He Z, Peng Z, et al.USA). All secondary antibodies were obtained from Affinity (Affinity). The calcium ionophore (MCE, HY-N6687) was purchased from MCE company (Shanghai, China). Antimycin A (ab141904) was obtained from Abcam (Cambridge

(12) Calmodulin Binding Activates Chromobacterium CopC Effector to ADP-Riboxanate Host Apoptotic CaspasesmBioJune 28, 2022Yaxin Liu, Huan Zeng, Yanjie Hou, Zilin Li, Lin Li, Xiaocui Song, Jingjin Ding, Feng Shao, Yue XuAc-IETD-AFC (17480), and Ac-LEHD-AFC (17051) were from Cayman Chemical. CALP3 (HY-P1075) and Calcimycin (HY-N6687) were from MedChemExpress. Glutathione-Sepharose beads (17513202) and Ni-NTA agarose resin (17057502)

(13) Amino acid starvation-induced LDLR trafficking accelerates lipoprotein endocytosis and LDL clearanceEMBO reportsFebruary 3, 2022Chen Y, Wu X, Zhang J, Pan G, Wang X, Guo X, Wang J, Cui X, Gao H, Cheng M, et al.(A2570), and concanamycin A (A8633) were from APExBIO (Houston, TX, USA). GCN2iB (HY‐112654), A23187 (HY‐N6687), and bafilomycin A1 (HY‐100558) were from MedChemExpress (Monmouth Junction, NJ, USA). LDL (YB001)

(14) Conformational change of adenine nucleotide translocase-1 mediates cisplatin resistance induced by EBV-LMP1EMBO molecular medicineDecember 7, 2021Zhao L, Deng X, Li Y, Hu J, Xie L, Shi F, Tang M, Bode AM, Zhang X, Liao W, et al.China), calcein‐AM (17783, Sigma‐Aldrich, USA), CoCl2 (V900021, Sigma‐Aldrich, USA), calcimycin (A23187, HY‐N6687, MCE, China), Magnesium green™ (M3733, Invitrogen, USA), STMRM, (T668, Invitrogen, USA), ATP Determination

(15) Calcimycin mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent mannerBiochimica et biophysica acta. General subjectsDecember 1, 2017Mawatwal S, Behura A, Ghosh A, Kidwai S, Mishra A, Deep A, Agarwal S, Saha S, Singh R, Dhiman R.

(16) Modulation of intracellular calcium homeostasis blocks autophagosome formationAutophagyOctober 1, 2013Engedal N, Torgersen ML, Guldvik IJ, Barfeld SJ, Bakula D, Sætre F, Hagen LK, Patterson JB, Proikas-Cezanne T, Seglen PO, et al.

(17) Characterization of the biosynthesis gene cluster for the pyrrole polyether antibiotic calcimycin (A23187) in Streptomyces chartreusis NRRL 3882Antimicrobial agents and chemotherapyMarch 1, 2011Wu Q, Liang J, Lin S, Zhou X, Bai L, Deng Z, Wang Z.

(18) IKCa1 activity is required for cell shrinkage, phosphatidylserine translocation and death in T lymphocyte apoptosisEMBO reportsFebruary 1, 2003Elliott JI, Higgins CF.

(19) Witness for the prosecutionNursing timesJuly 19, 2001Condliffe B.

(20) Effect of norathyriol, isolated from Tripterospermum lanceolatum, on A23187-induced pleurisy and analgesia in miceNaunyn-Schmiedeberg's archives of pharmacologyJuly 1, 1994Wang JP, Ho TF, Lin CN, Teng CM.

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Calcimycin from MedChemExpress

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Calcimycin from MedChemExpress

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