CCCP from MedChemExpress

Product Specs
ItemCCCP
CompanyMedChemExpress
Price $55.00Supplier Page View Company Product Page
Catalog NumberHY-100941
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.83%
FormulaC9H5ClN4
Research AreaInflammation/Immunology; Cancer
TypeChemical
Molecular Weight204.62
Quantity10 mM * 1 mL
Molecule NameCCCP

Add to Compare List

MedChemExpress

1 Deer Park Drive, Suite F

MONMOUTH JUNCTION, NJ 08852

United States

Phone: US Tel: 609-228-6898
US Fax: 609-228-5909
EU Tel: +4686500910

Email: sales@medchemexpress.com
eu.sales@MedChemExpress.com

Company Profile

Website: medchemexpress.com

(1) Coronavirus infectious bronchitis virus spike protein inhibits FUNDC1-mediated mitophagy to prevent nucleocapsid protein degradationJournal of VirologyMay 19, 2026Jun Zhao, Jiaxin Tian, Liwei Zhang, Yingfei Li, Lihua Tang, Qila Sa, Ruotong Li, Jing Zhao, Ye Zhao, Guozhong Zhangdrugs used in this study—rapamycin (HY-10219), bafilomycin A1 (HY-100558), FCCP (HY-100410R), CCCP (HY-100941), and LY294002 (HY-10108)—were obtained from Med Chem Express (MCE, Princeton, New Jersey, USA). Plasmids The

(2) Measurement of mitochondria amount and clearance using flow cytometry: effect of mitophagy inhibitors in leukemia cellsCancer & MetabolismApril 3, 2026Tereza Kořánová, Dana Grebeňová, Kateřina Kuželováfor individual cell lines. Chemicals and buffers XRK3F2 (HY-112904), mDivi-1 (HY-15886), and CCCP (HY-100941) were purchased from MedChemExpress; chloroquine (C6628) and propidium iodide (PI, P-4170) from Sigma-Aldrich;

(3) Topical NAMPT activation restores mitophagic flux to rescue diabetic keratopathy via the NAD⁺/PINK1 pathwayCell Communication and SignalingMarch 9, 2026Qian Guo, Guannan Huang, Wanting Li, Yunjing Ma, Haini Liu, Zihao Liu, Limin Zhu, Lechong Ma, Qingjun Zhou, Shaozhen Zhao5′-GAAGCCAUCUUGAACACAA-3′/antisense: 5′-UUGUGUUCAAGAUGGCUUC-3′; GenePharma), a CCCP uncoupler (10 µM, 6 h; HY-100941, MedChemExpress), and nicotinamide mononucleotide (NMN, 500 µM, HY-F0004S, MedChemExpress). Transfection

(4) Synergistic microscopic platform for probing molecular interaction on mitochondria-lysosome contact membraneBiomedical Optics ExpressMarch 1, 2026Hongfei Suo, Jiayu Zhou, Yao Lu, Jiahua Chen, Juanjuan Zheng, Sha An, Kai Wen, Peng Gao, Xiaofang Wang, Tanping Li, et al.and leads to Parkin phosphorylation at Ser65 [33,34]. In the experiment, a stock solution of CCCP (HY-100941, MedChemExpress, USA) was diluted with DMEM medium at a ratio of 1:100 (v:v). Before adding CCCP, mitochondria

(5) Inhibiting HSP27 activates the XBP1s/CerS1 interplay, which triggers DRP1-driven mitophagy, thereby protecting against cell death and promoting the KSHV lytic cycle in primary effusion lymphoma cellsCell Death DiscoveryFebruary 26, 2026Roberta Gonnella, Vincenzo Corrado, Giulio Francesco Scaffidi, Rossella Benedetti, Michele Di Crosta, Roberta Zarrella, Maria Saveria Gilardini Montani, Roberta Santarelli, Mara CironeMonmouth Junction, NJ, USA; cat. n HY-15886), CCCP (MedChemExpress, Monmouth Junction, NJ, USA; cat. N. HY-100941), Ceapin A7 (ATF6 signaling inhibitor, MedChemExpress, Monmouth Junction, NJ, USA; cat. n. HY-108434),

(6) Synergistic microscopic platform for probing molecular interaction on mitochondria-lysosome contact membraneBiomed Opt ExpressFebruary 19, 2026Hongfei Suo, Jiayu Zhou, Yao Lu, Jiahua Chen, Juanjuan Zheng, Sha An, Kai Wen, Peng Gao, Xiaofang Wang, Tanping Li, et al.and leads to Parkin phosphorylation at Ser65 [33,34]. In the experiment, a stock solution of CCCP (HY-100941, MedChemExpress, USA) was diluted with DMEM medium at a ratio of 1:100 (v:v). Before adding CCCP, mitochondria

(7) Phase separation of OPTN initiates mitophagy to orchestrate craniofacial bone mineralizationAutophagyFebruary 15, 2026Haojie Liu, Zhenyi Lu, Xinyu Zhang, Yan Wang, Xiao Ge, Simai Chen, Yumeng Shi, Jingjing Yan, Rongyao Xu, Junqing Ma, et al.induction/inhibition and oxidative stress induction To induce mitophagy, cells were treated with 10 µM CCCP (MCE, HY-100941) for 2 h and then used for immunofluorescence or phase separation experiments. To induce mitophagy for

(8) Porcine epidemic diarrhea virus promotes viral replication via ROS/HIF-1α-mediated glycolysisRedox BiologyFebruary 1, 2026Yafang Xu, Jinqiu Zhang, Chengwei Yin, Laizhen Liu, Zhenglei Wang, Shaodong Fu, Rong Fan, Yanyan Zhao, Jinfeng MiaoN-Acetyl-l-cysteine (NAC; HY-B0215), Rotenone (ROT; HY-B1756), and Carbonyl cyanide 3-chlorophenylhydrazone (CCCP; HY-100941) were purchased from MedChemExpress (MCE, China). (L)-Sodium lactate (Lac; T4103) was purchased from

(9) Carbon-based quantum dots enhance platelets aggregation through migrasomes biogenesisJournal of NanobiotechnologyJanuary 17, 2026Ang Li, Leiliang Zhangguidelines. ISA2011B (HY-16937), NSC23766 (HY-15723), carbonyl cyanide 3-chlorophenylhydrazone (CCCP) (HY-100941), and filipin complex (HY-N6716) were acquired from MedChemExpress (Princeton, NJ, USA). FITC-labeled

(10) USP34 attenuates cartilage degradation in temporomandibular joint osteoarthritis by ANT1-mediated mitophagyJBMR PlusJanuary 12, 2026Shuang Jiang, Danling Chen, Rui Sheng, Quan Yuan, Jian Pan, Yuchen Guounderlying mechanisms, cells were pre-treated with 2 μM carbonyl cyanide 3-chlorophenylhydrazone (CCCP; HY-100941; MedChemExpress), a mitochondrial uncoupler, to induce mitochondrial depolarization.23 Gene knockdown

(11) Fe‐S Protein FDX1 Triggers Tumor‐Intrinsic Innate Immunity via Mitochondrial Nucleic Acids Release to Orchestrate Ferroptosis in CCRCCAdvanced ScienceJanuary 1, 2026Xing Huang, Shaoqing Yu, Wenjie Wei, Wen Tao, Tianwei Cai, Lequan Wen, Jiali Ye, Chi Zhang, Huayi Feng, Senming Cao, et al.elesclomol (HY‐12040), 3‐methyladenine (HY‐19312), MG‐132 (HY‐13259), chloroquine (HY‐17589A), CCCP (HY‐100941), and NH4Cl (HY‐Y1269C), purchased from MedChemExpress; and CuCl2 (751944) from Sigma–Aldrich. RNA

(12) Nanoparticle-mediated overexpression of RacGAP1 protects against renal ischemia/reperfusion injury by maintaining mitochondrial homeostasisClin Sci (Lond)November 27, 2025Weiran Zhou, Shiqiang Tong, Jinbo Yu, Jun Chen, Yi Fang, Yuxin Nie, Yiqin Shi, Nana Song, Xuesen Cao, Xiaoqiang Ding, et al.in vitro, the mRTECs were then incubated with 10 μM carbonyl cyanide m-chlorophenylhydrazone (CCCP, HY-100941, MCE) in medium without FBS for 4 h, followed by a 2-h recovery period in a complete culture medium.

(13) Nanoparticle-mediated overexpression of RacGAP1 protects against renal ischemia/reperfusion injury by maintaining mitochondrial homeostasisClinical ScienceNovember 27, 2025Weiran Zhou, Shiqiang Tong, Jinbo Yu, Jun Chen, Yi Fang, Yuxin Nie, Yiqin Shi, Nana Song, Xuesen Cao, Xiaoqiang Ding, et al.in vitro, the mRTECs were then incubated with 10 μM carbonyl cyanide m-chlorophenylhydrazone (CCCP, HY-100941, MCE) in medium without FBS for 4 h, followed by a 2-h recovery period in a complete culture medium.

(14) A generative deep learning approach to de novo antibiotic designCellOctober 16, 2025Aarti Krishnan, Melis N. Anahtar, Jacqueline A. Valeri, Wengong Jin, Nina M. Donghia, Leif Sieben, Andreas Luttens, Yu Zhang, Seyed Majed Modaresi, Andrew Hennes, et al.hydrate, Cayman Chemical, 18866), fosfomycin sodium (MilliporeSigma, 34089), CCCP (MedChemExpress, HY-100941), and fusidic acid (Millipore Sigma F0881), all dissolved in DMSO. Kanamycin sulfate (MilliporeSigma,

(15) TRAP1 inhibits KANSL3 acetylation to alleviate mitochondrial dysfunction by promoting mitophagy in cardiomyocytes under diabetic conditionsCell communication and signaling : CCSOctober 2, 2025Zhang X, Cheng S, Li W, Xu X, Huang X, Chen Z, Li Q, Huang W, Zhang L, Ouyang M.treated with HG/PA or control medium for 24 h. Carbonyl cyanide 3-chlorophenylhydrazone (CCCP; 10 µM, HY-100941, MedChemExpress) was used to activate mitophagy. Cell viability A Cell Counting Kit-8 (CCK8; CK04;

(16) EF1α, rather than CMV promoter, is suitable for luciferase tag expression in target cells for in vitro cytotoxicity assays of CAR-T cellsMolecular Therapy Methods & Clinical DevelopmentSeptember 11, 2025Rui Hou, Zejun Zhang, Huan Li, Wenyin He, Xu Wang, Xuan Zhao, Sijin Li, Zhangchun Guan, Dan Liu, Junnian Zheng, et al.ratios for 24 h. For cytotoxicity assay of CCCP, various concentrations of CCCP (MedChemExpress, no. HY-100941) were added to the culture medium for 48 h after the target cells were labeled with 5 μM CFSE. The number

(17) PINK1 deficiency permits the development of Lewy body dementia with coexisting Aβ pathologyAlzheimer's & dementia : the journal of the Alzheimer's AssociationSeptember 1, 2025Gao TY, Wang XZ, Xie YH, Wang T, Lu YB, Huang LL, Chen C, Zhang M, Ma X, Chen YL, et al.levels were assessed by western blotting in the presence or absence of 10 µM CCCP (MedChemExpress; Cat. HY‐100941) treatment for 2 hours. 2.3.3 Behavioral tests for the transgenic mice A Y‐maze test was conducted

(18) Activation of endogenous PRKN by structural derepression is linked to increased turnover of the E3 ubiquitin ligaseAutophagyJuly 18, 2025Fabienne C. Fiesel, Bernardo A. Bustillos, Jens O. Watzlawik, Carol X.Q. Chen, Martin H. Berryer, Jiazhen Zhang, Paige K. Boneski, Caleb S. Hayes, Jenny M. Bredenberg, Eric Deneault, et al.neurons Two-week-old iPSC-derived neurons were treated with DMSO or CCCP (10 µM in DMSO; MedChemExpress, HY-100941) for 24 h at 37ºC. Cells were resuspended in cold 1X PBS and centrifuged at 1,000 × g for 10 min, and

(19) Inhibition of mitophagy via the EIF2S1-ATF4-PRKN pathway contributes to viral encephalitisJournal of Advanced ResearchJuly 1, 2025Xiaowei Song, Yiliang Wang, Weixiangmin Zou, Zexu Wang, Wenyan Cao, Minting Liang, Feng Li, Qiongzhen Zeng, Zhe Ren, Yifei Wang, et al.(382451), FIS1 (505821) were purchased from ZEN-Bioscience (Chengdu, China). Small chemicals CCCP (HY-100941) and Mdivi-1 (HY-15886) were from MCE (Shanghai, China). Taurine (T4454) was purchased from TargetMol

(20) Therapeutic Potential of CHCHD2 in Ischemia-Reperfusion Injury: Mechanistic Insights into Nrf2-Dependent Antioxidant Defense in HK2 CellsInternational journal of molecular sciencesJune 25, 2025Hao Y, Zhou X.important avenue for further exploration. 4. Materials and Methods 4.1. Chemicals and Reagents CCCP (HY-100941, ≥99% purity) was obtained from MedChemExpress (Monmouth Junction, NJ, USA). MEM (PIG0029) was sourced

Be the First to Write a Review!

Description

MedChemExpress

Citations (56)

Reviews

CCCP from MedChemExpress

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map