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Protein Biochemistry
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PLX-4720
PLX-4720 from MedChemExpress
Be the first to write a review!
Citations:
(7)
Supplier Page
Supplier Page from
MedChemExpress for
PLX-4720
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Description
PLX-4720 is a potent and selective inhibitor of
B-Raf
V600E
with
IC
50
of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), and 10-fold selectivity for B-Raf
V600E
than wild-type B-Raf
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
PLX-4720
Company
MedChemExpress
Price
$68.00
Supplier Page
View Company Product Page
Catalog Number
HY-51424
Research Area
Cancer
Formula
C₁₇H₁₄ClF₂N₃O₃S
Molecular Weight
413.83
Type
Chemical
Purity
99.90%
Applications
Bioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Quantity
10 mM * 1 mL
Add to Compare List
MedChemExpress
1 Deer Park Drive, Suite F
MONMOUTH JUNCTION
,
NJ
08852
United States
Phone
: US Tel: 609-228-6898
US Fax: 609-228-5909
EU Tel: +4686500910
Email: sales@medchemexpress.com
eu.sales@MedChemExpress.com
Company Profile
Website:
medchemexpress.com
Citations (7)
(1)
Large-scale characterization of drug mechanism of action using proteome-wide thermal shift assays
Elife
November 11, 2024
Jonathan G Van Vranken, Jiaming Li, Julian Mintseris, Ting-Yu Wei, Catherine M Sniezek, Meagan Gadzuk-Shea, Steven P Gygi, Devin K Schweppe
compound,
SP2509
,
MedChemExpress
,
HY-12635
, Chemical compound,
Lapatinib
,
MedChemExpress
,
HY-50898
, Chemical compound,
PLX-4720
,
MedChemExpress
,
HY-51424
, Chemical compound,
CCT241533 (hydrochloride
),
MedChemExpress
,
HY-14715B
, Chemical compound,
Volasertib
,
MedChemExpress
,
HY-12137
, Chemical
(2)
Activation of the NLRP1 inflammasome in human keratinocytes by the dsDNA mimetic poly(dA:dT)
Proceedings of the National Academy of Sciences
January 31, 2023
Jeffrey Y. Zhou, Mrinal K. Sarkar, Ken Okamura, John E. Harris, Johann E. Gudjonsson, Katherine A. Fitzgerald
KU-44933 (
Santa Cruz
#
sc-202963
),
NU-7441
(
Tocris
#
3712
),
Sorafenib
(Sigma #SML2633),
PLX-4720
(
MCE
#
HY-51424
),
Doramapimod
(
MCE
#
HY-10320
),
SB-202190
(
MCE
#
HY-10295
), and
RNA Polymerase III inhibitor
(
Sigma
#557403).
(3)
Neuropilin-1 upregulation elicits adaptive resistance to oncogene-targeted therapies
The Journal of clinical investigation
August 31, 2018
Rizzolio S, Cagnoni G, Battistini C, Bonelli S, Isella C, Van Ginderachter JA, Bernards R, Di Nicolantonio F, Giordano S, Tamagnone L.
(4)
Effect of an anaesthesia information video on preoperative maternal anxiety and postoperative satisfaction in elective caesarean section: a prospective randomised trial
Anaesthesia and intensive care
November 1, 2013
Eley VA, Searles T, Donovan K, Walters E.
(5)
PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression
Cancer research
April 1, 2011
Paraiso KH, Xiang Y, Rebecca VW, Abel EV, Chen YA, Munko AC, Wood E, Fedorenko IV, Sondak VK, Anderson AR,
et al
.
(6)
B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression
Proceedings of the National Academy of Sciences of the United States of America
June 8, 2010
Nucera C, Porrello A, Antonello ZA, Mekel M, Nehs MA, Giordano TJ, Gerald D, Benjamin LE, Priolo C, Puxeddu E,
et al
.
(7)
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
Proceedings of the National Academy of Sciences of the United States of America
February 26, 2008
Tsai J, Lee JT, Wang W, Zhang J, Cho H, Mamo S, Bremer R, Gillette S, Kong J, Haass NK,
et al
.
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PLX-4720 from MedChemExpress
Supplier Page
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$68.00
Product Specs
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