AGK2 from MedChemExpress

Product Specs
ItemAGK2
CompanyMedChemExpress
Price $93.00Supplier Page View Company Product Page
Catalog NumberHY-100578
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.62%
TypeChemical
Molecular Weight434.27
FormulaC₂₃H₁₃Cl₂N₃O₂
Research AreaCancer

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(1) Jaceosidin Attenuates Sepsis-Induced Myocardial Dysfunction by Promoting SIRT2-Mediated Inhibition of Histone H3K18 LactylationPharmaceuticals (Basel)January 4, 2026Huiming Yu, Minfu Liu, Shuwan Hou, Jiaqin Wu, Qianqian Du, Fan Feng, Sixiang Wang, Chunli Wang, Kang Xuabout the role of SIRT2, we treated cells with AGK2 (MedChemExpress, Monmouth Junction, NJ, USA, Cat: HY-100578 CAS No: 304896–28–4). A statement to confirm that all methods were carried out in accordance with relevant

(2) Enhancing intestinal epithelial microtubule stability could alleviate IBD symptomsCell Commun SignalJune 4, 2025Fangying Yang, Zhengxiao He, Xiumei Pan, Shuping Xie, Xinhua Liang, Lanlan Geng, Wanfu Xu, Sitang Gongmice. MARK2fl/fl and MARK2vil1 mice were subjected to 2.5% DSS solution as described above. AGK2 (MCE, HY-100578) was dissolved in sterile saline and administered via intraperitoneal injection at a dose of 25 mg/kg.

(3) Swimming Exercise Pretreatment Attenuates Postoperative Delirium-Like Behavior in Type 2 Diabetic Rats by Enhancing Mitochondrial Biogenesis Through Activation of SIRT2 DeacetylationMedComm (2020)March 18, 2025Kaixi Liu, Lei Chen, Xinning Mi, Qian Wang, Yitong Li, Jingshu Hong, Xiaoxiao Wang, Yue Li, Yanan Song, Yi Yuan, et al.anteroposterior, ±2.5 mm mediolateral, and −3.15 mm dorsoventral). SIRT2 inhibitor AGK2 (MedChemExpress, HY‐100578) was dissolved in 4% dimethyl sulfoxide and diluted in PBS. The volume of AGK2 (200 µM) was 2.5 µL per

(4) Inhibition of Sirt2 Alleviates Fibroblasts Activation and Pulmonary Fibrosis via Smad2/3 PathwayFrontiers in pharmacologyJanuary 1, 2021Gong H, Zheng C, Lyu X, Dong L, Tan S, Zhang X.were treated with TGF-β1 at 2 ng/ml for 24 h, and then added 10 μM AGK2 (an inhibitor of Sirt2) (MCE, HY-100578) or vehicle control (dimethyl sulfoxide, a AGK2 solvent) for another 24 h in the presence of TGF-β1. RNA

(5) Sirtuin inhibitors, EX527 and AGK2, suppress cell migration by inhibiting HSF1 protein stabilityOncology reportsJanuary 1, 2016Kim HW, Kim SA, Ahn SG.

(6) Selective Inhibition of SIRT2 Improves Outcomes in a Lethal Septic ModelCurrent molecular medicineJanuary 1, 2015Zhao T, Alam HB, Liu B, Bronson RT, Nikolian VC, Wu E, Chong W, Li Y.

(7) Identification of novel SIRT2-selective inhibitors using a click chemistry approachBioorganic & medicinal chemistry lettersApril 15, 2014Tatum PR, Sawada H, Ota Y, Itoh Y, Zhan P, Ieda N, Nakagawa H, Miyata N, Suzuki T.

(8) Poly(ADP-ribose) polymerase mediates both cell death and ATP decreases in SIRT2 inhibitor AGK2-treated microglial BV2 cellsNeuroscience lettersJune 7, 2013Li Y, Nie H, Wu D, Zhang J, Wei X, Ying W.

(9) [Which approach should be chosen for inverted nasosinusal papilloma?]Revue de laryngologie - otologie - rhinologieJanuary 1, 1990Jankowski R, Lhuillier C, Simon C, Wayoff M.

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AGK2 from MedChemExpress

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