PP2 from MedChemExpress

Product Specs
ItemPP2
CompanyMedChemExpress
Price $87.00Supplier Page View Company Product Page
Catalog NumberHY-13805
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity98.34%
TypeChemical
Molecular Weight301.77
FormulaC₁₅H₁₆ClN₅
Research AreaCancer

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(1) Potential targets and molecular mechanisms of D-pinitol against acute kidney injury based on network pharmacology and experimental validationRen FailAugust 10, 2026Yilin Ren, Yuan Ge, Keyu Zhang, Hui Lin, Dan Niu, Weixia Han, Xiaole Su, Lihua Wang, Xi Qiao5 μM), high-dose DP (HDP, 10 μM), or high-dose DP combined with the SRC inhibitor PP2 (10 μM, MCE, HY-13805, Monmouth Junction, NJ, USA) for 1h prior to H/R exposure [37,38]. PP2 was first dissolved in DMSO and

(2) Association between primary aldosteronism and type 2 diabetes and identification of potential molecular mechanismsFront Endocrinol (Lausanne)August 4, 2026Chaoyan Tang, Liheng Meng, Haiyun Lan, Jing Xian, Cuihong Chen, Lijun Pang, Yingfen Qinlevel. PP2 was purchased in powder form from MedChem Express (MCE) and stored at 4 °C (product code: HY-13805). PP2 was dissolved in DMSO at a concentration of 10μM according to the manufacturer’s instructions

(3) ATP1A1 enhances porcine reproductive and respiratory syndrome virus type 2 attachment and internalizationmBioApril 8, 2026Haotian Yang, Bicheng Li, Xudong Yin, Aldryan Cristianto Pratama, Fang Hehydrochloride (CPZ, HY-B0407A), genistein (GEN, HY-14596), ethylisopropylamiloride (EIPA, HY-101840), PP2 (HY-13805), Src inhibitor 1 (Src-l1, HY-101053), ouabain octahydrate (ouabain, HY-B0542), and rostafuroxin (PST2238,

(4) PKM2 phosphorylation by c-SRC activates glycolysis and metastasis with the stimulation of tumor-associated macrophagesCell Communication and SignalingMarch 12, 2026Da Song, Haijie Li, Jialu Xu, Wenli Zhan, Yaqi Chen, Xuelai Luo, Guihua Wang, Xingrui Li, Junbo Hu, Jingqin LanAbbkine); and Dylight 549, goat anti-mouse IgG (A23310, Abbkine). Other materials used, including PP2 (HY-13805, MedChemExpress), SU6656 (HY-B0789, MedChemExpress), anti-Flag magnetic beads (B26101, Bimake), anti-HA magnetic beads

(5) A hotspot phosphorylation site on SHP2 drives oncoprotein activation and drug resistanceNature CommunicationsMarch 3, 2026Prashath Karunaraj, Remkes Scheele, Malcolm L. Wells, Ruchita Rathod, Ipek S. Gokulu, Sophia R. Abrahamson, Lila Taylor, Lamia Chowdhury, Abiha Kazmi, Weixiao Song, et al.HY-104010), ripretinib (Cat# HY-112306), SU6656 (Cat# HY-B0789), CH6953755 (Cat# HY-135299), and PP2 (Cat# HY-13805) were purchased from MedChemExpress, NJ, USA. For drug treatment assays (RTK inhibitors and SFK inhibitors),

(6) A Hotspot Phosphorylation Site on SHP2 Drives Oncoprotein Activation and Drug ResistanceResearchSquareAugust 5, 2025Prashath Karunaraj, Prashath Karunaraj, Malcolm L. Scheele, Malcolm Rathod, Ipek Simay Rathod, Sophia Abrahamson, Sophia Abrahamson, Lamia Chowdhury, Lamia Chowdhury, Weixiao Kazmi, et al.HY-104010), Ripretinib (Cat# HY-112306), SU6656 (Cat# HY-B0789), CH6953755 (Cat# HY-135299), and PP2 (Cat# HY-13805) were purchased from MedChemExpress, NJ, USA. For drug treatment assays (RTK inhibitors and SFK inhibitors),

(7) A Hotspot Phosphorylation Site on SHP2 Drives Oncoprotein Activation and Drug ResistancebioRxivJune 19, 2025Prashath Karunaraj, Remkes Scheele, Malcolm L. Wells, Ruchita Rathod, Sophia Abrahamson, Lila C. Taylor, Ipek S. Gokulu, Lamia Chowdhury, Abiha Kazmi, Weixiao Song, et al.HY-104010), Ripretinib (Cat# HY-112306), SU6656 (Cat# HY-B0789), CH6953755 (Cat# HY-135299), and PP2 (Cat# HY-13805) were purchased from MedChemExpress, NJ, USA. For drug treatment assays (RTK inhibitors and SFK inhibitors),

(8) 5-O-Methylvisammioside alleviates depression-like behaviors by inhibiting nuclear factor kappa B pathway activation via targeting SRCNeural Regen ResApril 29, 2025Wenqian Zhu, Bingjin Li, Ranji CuiNature-standard, Shanghai, China), Flu (10 mg/kg per day; PHR1394-1g, Sigma Aldrich), and PP2 (2.5 mg/kg per day; HY-13805, MedChemExpress, Monmouth Junction, NJ, USA) were administered via intraperitoneal injection using a

(9) NMN Supplementation Inhibits Endothelial Cell ROS-Mediated Src/Pi3k/Akt Signaling Pathway to Protect High-Altitude Blood-Retinal BarrierInvest Ophthalmol Vis SciApril 18, 2025Siyuan Liu, Ning Du, Keke Ge, Jiayue Hu, Wenfang Zhangstarted 1 hour before hypoxia. To study the effects of the Src family inhibitor PP2 on cells, PP2 (HY-13805, MedChemExpress, China) was dissolved in DMSO to a final concentration of 10 µM, and intervention began

(10) The protein segregase VCP/p97 promotes host antifungal defense via regulation of SYK activationPLOS PathogensOctober 29, 2024Zhugui Shao, Li Wang, Limin Cao, Tian Chen, Xin-Ming Jia, Wanwei Sun, Chengjiang Gao, Hui Xiaopoly(I:C) were purchased from sigma; NMS-873 (S7285), PRT (S7738) were purchased from Selleck. PP2 (HY-13805), CB-5083 (HY-12861), DBeQ (HY-15945), ML240 (HY-19795) and TPI-1 (HY-100463) were purchased from MCE.

(11) The proto-oncogene tyrosine kinase c-SRC facilitates glioblastoma progression by remodeling fatty acid synthesisNature CommunicationsAugust 28, 2024Wentao Zhao, Cong Ouyang, Liang Zhang, Jinyang Wang, Jiaojiao Zhang, Yan Zhang, Chen Huang, Qiao Xiao, Bin Jiang, Furong Lin, et al.from Thermo Fisher Scientific. Collagenase I (Cat# SCR103) was purchased from Sigma-Aldrich. PP2 (Cat. HY-13805) was purchased from MedChemExpress. Saracatinib (Cat. 379231-04-6) was purchased from Selleck Chemicals.

(12) Mechanochemical coupling of MGF mediates periodontal regenerationBioengineering & translational medicineJanuary 1, 2024Zhao Y, Zhang S, Cheng B, Feng F, Zhu Y, Liu Y, Wang J, Zou D, Ma H, Xu F, et al.4‐Amino‐5‐(4‐chlorophenyl)‐7‐(t‐butyl) pyrazolo[3,4‐d] pyrimidine (PP2), which was purchased from MedChemExpress (HY‐13805, Trenton, NJ, USA). According to the previous study, PP2 at a concentration of 10 μM inhibits Src activity

(13) DAB2IP suppresses invadopodia formation through destabilizing ALK by interacting with USP10 in breast canceriScienceSeptember 15, 2023Huang Q, Zhang R, Xia Y, Shen J, Dong H, Li X, Tao D, Xie D, Liu L.,Thermo Scientific,Cat# R0533 Lipofectamine 2000,Invitrogen,Cat# 12566014 ASP3026,MCE,Cat# HY-13326 PP2,MCE,Cat# HY-13805 MG132,MCE,Cat# HY-13259 Cycloheximide (CHX),MCE,Cat# HY-12320 G418,MCE,Cat# HY-17561 Puromycin dihydrochloride,MCE,Cat#

(14) Targeting protein tyrosine phosphatases for CDK6-induced immunotherapy resistanceCell reportsApril 25, 2023Gao X, Wu Y, Chick JM, Abbott A, Jiang B, Wang DJ, Comte-Walters S, Johnson RH, Oberholtzer N, Nishimura MI, et al.proteins",, ,, BSJ-03–123,MedChemExpress,HY-111556 Palbociclib,MedChemExpress,HY-50767A PTP1B-IN2,MedChemExpress,HY-100462 PP2,MedChemExpress,HY-13805 LIVE/DEAD yellow staining kit,Invitrogen,L34965 CD16/32 blocking FC,VWR,101302 Leukocyte Activation

(15) Pseudorabies Virus Regulates the Extracellular Translocation of Annexin A2 To Promote Its ProliferationJournal of virologyMarch 30, 2023Weng M, Guo Z, Lu Q, Jin Q, Jiang Y, Wang F, Guo J, Xing G, Qiao S, Zhang G.(13778150) were purchased from Thermo Fisher Scientific (Waltham, MA, USA). A2ti-1 (HY-136465) and PP2 (HY-13805) were purchased from MedChemExpress (South Brunswick, NJ, USA). RNA interference. All siRNA-negative

(16) B-lymphoid tyrosine kinase-mediated FAM83A phosphorylation elevates pancreatic tumorigenesis through interacting with β-cateninSignal transduction and targeted therapyFebruary 17, 2023Zhou C, Zhu X, Liu N, Dong X, Zhang X, Huang H, Tang Y, Liu S, Hu M, Wang M, et al.inhibitor saracatinib and LCK kinase inhibitor PP2 were both purchased from MedChemExpress (HY-10234 and HY-13805). Cycloheximide (CHX) and MG132 were purchased from Selleck (S7418 and S2619). Western blotting and immunoprecipitation

(17) Src Inhibition Attenuates Neuroinflammation and Protects Dopaminergic Neurons in Parkinson’s Disease ModelsFrontiers in NeuroscienceFebruary 18, 2020Hanyu Yang, Lu Wang, Caixia Zang, Yue Wang, Junmei Shang, Zihong Zhang, Hui Liu, Xiuqi Bao, Xiaoliang Wang, Dan Zhangatmosphere of 5% CO2. Chemical Reagents For in vitro study, Src family kinase inhibitor PP2 (Cat#HY-13805, MCE, United States) was dissolved in dimethyl sulfoxide (DMSO; Cat#0231, AMRESCO, United States) to

(18) Phosphorylation of NMDA receptor GluN2B subunit at Tyr1472 is important for trigeminal processing of itchThe European journal of neuroscienceOctober 1, 2016Inoue A, Uchida H, Nakazawa T, Yamamoto T, Ito S.

(19) AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processesMolecular cancer therapeuticsDecember 1, 2005Summy JM, Trevino JG, Lesslie DP, Baker CH, Shakespeare WC, Wang Y, Sundaramoorthi R, Metcalf CA 3rd, Keats JA, Sawyer TK, et al.

(20) Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activationThe Journal of biological chemistryJanuary 12, 1996Hanke JH, Gardner JP, Dow RL, Changelian PS, Brissette WH, Weringer EJ, Pollok BA, Connelly PA.

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