Apixaban from MedChemExpress | Biocompare.com

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Apixaban

Description

Apixaban (BMS-562247-01) is a highly selective, reversible and orally active inhibitor of Factor Xa with K_i of 0.08 nM and 0.17 nM in human and rabbit, respectively. Apixaban is in development for the prevention and treatment of various thromboembolic diseases

Product Specs
ItemApixaban
CompanyMedChemExpress
Price $70.00Supplier Page View Company Product Page
Catalog NumberHY-50667
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.99%
TypeChemical
Molecular Weight459.50
Molecule NameApixaban
FormulaC25H25N5O4
Research AreaCardiovascular Disease; Cancer

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(1) Preclinical pharmacokinetics and pharmacodynamics of apixaban, a potent and selective factor Xa inhibitorEuropean journal of drug metabolism and pharmacokineticsSeptember 1, 2011He K, Luettgen JM, Zhang D, He B, Grace JE Jr, Xin B, Pinto DJ, Wong PC, Knabb RM, Lam PY, et al.

(2) Metabolism, pharmacokinetics and pharmacodynamics of the factor Xa inhibitor apixaban in rabbitsJournal of thrombosis and thrombolysisJanuary 1, 2010Zhang D, He K, Raghavan N, Wang L, Crain EJ, He B, Xin B, Luettgen JM, Wong PC.

(3) Apixaban, an oral, direct and highly selective factor Xa inhibitor: in vitro, antithrombotic and antihemostatic studiesJournal of thrombosis and haemostasis : JTHMay 1, 2008Wong PC, Crain EJ, Xin B, Wexler RR, Lam PY, Pinto DJ, Luettgen JM, Knabb RM.

(4) Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor XaJournal of medicinal chemistryNovember 1, 2007Pinto DJ, Orwat MJ, Koch S, Rossi KA, Alexander RS, Smallwood A, Wong PC, Rendina AR, Luettgen JM, Knabb RM, et al.

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