GCN2iB from MedChemExpress

Product Specs
ItemGCN2iB
CompanyMedChemExpress
Price $275.00Supplier Page View Company Product Page
Catalog NumberHY-112654
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.83%
TypeChemical
Molecular Weight451.83
FormulaC₁₈H₁₂ClF₂N₅O₃S
Research AreaCancer

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(1) An inhibitor of GCN2 and the integrated stress response directly targets ZAK protein kinase to limit cytotoxicityJournal of Biological ChemistryJune 1, 2026Jagannath Misra, Dan F. Spandau, Jonah Z. Vilseck, Tracy G. Anthony, Kirk A. Staschke, Ronald C. Wek(Sigma-Aldrich, Cat. #75351), anisomycin (Sigma-Aldrich, Cat. #A9789), or GCN2iB (MedChemExpress, Cat. #HY-112654) as described in the results section and figure legends. UV irradiation HEK293T and NTERT cells were

(2) Tuning tRNA synthetase inhibition reveals parabolic induction of stress granules limited in size and RNA contentRNAJune 1, 2026Max Baymiller, Noah S. Helton, Benjamin Dodd, Stephanie L. Moondithiothreitol (DTT) at 2 mM for 1 h, 10 μg/mL puromycin (Gold Biosciences) for 30 min, and GCN2iB (MCE HY-112654) in DMSO at 10 µM for 4 h. Western blotting Cells were treated as indicated, washed in PBS, and then

(3) Activating GCN2 and subsequently the Unfolded Protein Response with the small oral molecule NXP800 delays tumor growth in osteosarcomaCell Death DiscovFebruary 5, 2026Emma Racineau, Morgane Lallier, Anaïs Postec, Jérôme Amiaud, Rose-Anne Thépault, Régis Brion, Séverine Battaglia, Céline Charrier, Marie-Anne Colle, Bénédicte Brounais-Le Royer, et al.kindly provided by Nuvectis Pharma, Inc. NXP800 was dissolved in DMSO at 10 mM. GCN2 inhibitor, GCN2iB (HY-112654), is purchased from MedChemExpress. GCN2iB was dissolved in DMSO at 20 mM and was used at a concentration

(4) Environmental Amino Acid Sensing Regulates the Rate of ASC Translation and NLRP3 Inflammasome AssemblybioRxivJanuary 23, 2026Mikel D. Haggadone, Brian P. Goldspiel, Aoife O’Farrell, Nora T. Kiledjian, Montana Knight, Talia R. Smith, Elena Anderson, Víctor R. Vázquez Marrero, Mark A. Boyer, Peining Jimmy Xu, et al.used: Torin 1 (Cayman Chemical #10997), rapamycin (MedChemExpress #HY-10219), GCN2iB (MedChemExpress #HY-112654), cycloheximide (Sigma-Aldrich #C4859), actinomycin D (Sigma-Aldrich #SBR00013), and Z-VAD-FMK (SM Biochemicals

(5) The Synergistic Effects of rhArg with Bcl-2 Inhibitors or Metformin Co-Treatment in Multiple Cancer Cell ModelsCellsJanuary 16, 2026Lai-Pan Sze, Vicky Mei-Ki Ho, Wing-Ki Fung, Kin-Ho Law, Yifan Tu, Yik-Hing So, Sai-Fung Chung, Wing-Leung Wong, Zhen Liu, Alisa Sau-Wun Shum, et al.units/mL penicillin G sulfate (Gibco) at 37 °C and 5% CO2. 2.3. Chemicals and Reagents GCN2iB (Cat. HY-112654), ABT199 (Cat. HY-15531) and ABT263 (Cat. HY-10087) were purchased from MedChemExpress (Monmouth Junction,

(6) Caloric Restriction Enhances the Efficacy of Anti-Androgen Therapy in Prostate Cancer by Inhibiting Androgen Receptor TranslationCancer ResNovember 3, 2025Ricardo A. Cordova, May Elbanna, Christopher Rupert, Sabrina A. Orsi, Noah R. Sommers, Angela J. Klunk, Li Shen, Jagannath Misra, Jocelyne N. Hanquier, Maria Tsompana, et al.(MedChemExpress, Cat. #HY-70002), cycloheximide (Sigma, Cat. #239763), GCN2iB (MedChemExpress, Cat. #HY-112654), halofuginone (Cayman Chemical, Cat. #13370), and anisomycin (Sigma, Cat. #A9789) were dissolved in

(7) Caloric Restriction Enhances the Efficacy of Anti-Androgen Therapy in Prostate Cancer by Inhibiting Androgen Receptor TranslationCancer ResearchNovember 3, 2025Ricardo A. Cordova, May Elbanna, Christopher Rupert, Sabrina A. Orsi, Noah R. Sommers, Angela J. Klunk, Li Shen, Jagannath Misra, Jocelyne N. Hanquier, Maria Tsompana, et al.(MedChemExpress, Cat. #HY-70002), cycloheximide (Sigma, Cat. #239763), GCN2iB (MedChemExpress, Cat. #HY-112654), halofuginone (Cayman Chemical, Cat. #13370), and anisomycin (Sigma, Cat. #A9789) were dissolved in

(8) Involvement of Integrated Stress Response in Drug-Induced Secondary DystoniaACS OmegaOctober 28, 2025Tricia A. Simon, Sanjana B. Parise, Natalie E. Jackson, Rekha C. PatelPKR inhibitor C16: Sigma-Aldrich 527450, PERK inhibitor GSK2656157 (MCE HY-13820), and GCN2 inhibitor (MCE HY-112654). Western Blot Analysis N2a cells were grown in DMEM containing 10% fetal bovine serum and penicillin/streptomycin

(9) Involvement of Integrated Stress Response in Drug-Induced Secondary DystoniaACS OmegaOctober 17, 2025Tricia A. Simon, Sanjana B. Parise, Natalie E. Jackson, Rekha C. PatelPKR inhibitor C16: Sigma-Aldrich 527450, PERK inhibitor GSK2656157 (MCE HY-13820), and GCN2 inhibitor (MCE HY-112654). Western Blot Analysis N2a cells were grown in DMEM containing 10% fetal bovine serum and penicillin/streptomycin

(10) Asparagine synthetase modulates glutaminase inhibitor sensitivity through metabolic reprogramming and serves as a prognostic biomarker in hepatocellular carcinomaRedox BiolAugust 5, 2025Benjian Gao, Dongning Zheng, Hong Liu, Yu Guo, Yuntao Ye, Zhou Chen, Fengyi Yang, Jie Liu, Guangnian Zhang, Guoying Feng, et al.antibodies CB-839 (#C174237) was purchased from Aladdin. General control nonderepressible-2-(GCN2) iB (#HY-112654), N-acetylcysteine (NAC, #HY-B0215), MHY1485 (#HY-B0795), rapamycin (#HY-10219), and l-glutamine-13C5

(11) Decoding post-transcriptional regulatory networks by RNA-linked CRISPR screening in human cellsNature MethodsJune 1, 2025Patrick J. Nugent, Heungwon Park, Cynthia L. Wladyka, James N. Yelland, Sayantani Sinha, Katharine Y. Chen, Christine Bynum, Grace Quarterman, Stanley C. Lee, Andrew C. Hsieh, et al.acquired from Apex Bio. Vemurafenib (S1267) was obtained from Selleckchem. SMG1i (HY-124719), GCN2iB (HY-112654), and eFT226 (HY-112163) were all purchased from Medchemexpress. Finally, 4E1RCat (S7370) was obtained

(12) An ISR-independent role of GCN2 prevents excessive ribosome biogenesis and mRNA translationLife Sci AllianceMarch 3, 2025Mónica Román-Trufero, Istvan T Kleijn, Kevin Blighe, Jinglin Zhou, Paula Saavedra-García, Abigail Gaffar, Marilena Christoforou, Axel Bellotti, Joel Abrahams, Abdelmadjid Atrih, et al.cell culture medium. GCN2 inhibition Cells were incubated for the indicated times with 1 μM of GCN2 inhibitor GCN2iB (HY-112654; MedChemExpress) or vehicle control (DMSO, D2650; Sigma-Aldrich), and medium was changed every 24 h. Cell viability assay

(13) eEF2K regulates pain through translational control of BDNFMolecular CellFebruary 20, 2025Patrick R. Smith, Guadalupe Garcia, Angela R. Meyer, Alexey G. Ryazanov, Tao Ma, Sarah Loerch, Zachary T. Campbell11421 (R)-MG132,Cayman Chemical,CAS No. 121187736-9; Cat No. 13697 GCN2iB,MedChemExpress,CAS No. 218347012-2; Cat No. HY-112654 Forskolin,Cayman Chemical,CAS No. 66575-299; Cat No.11018 Critical commercial assays,Critical commercial

(14) BRAF V600 and ErbB inhibitors directly activate GCN2 in an off-target manner to limit cancer cell proliferationbioRxivDecember 23, 2024C. Ryland Ryland, Nasreen C. Marikar, Vu Nguyen, Varuna Nangia, Alicia M. Darnell, Matthew G. Vander Heiden, Philip Reigan, Sabrina L. SpencerTMP (ThermoFisher #AAJ6305303), thapsigargin (Sigma-Aldrich, #0000192053), GCN2iB (MedChemExpress, #HY-112654), erlotinib (MedChemExpress, #HY-50896), gefitinib (Selleckchem, #S1025), palbociclib (Selleckchem,

(15) Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancerScience SignalingNovember 26, 2024Ricardo A. Cordova, Noah R. Sommers, Andrew S. Law, Angela J. Klunk, Katherine, E. Brady, David W. Goodrich, Tracy G. Anthony, Jeffrey J. Brault, Roberto Pili, Ronald C. Wek, et al.and 10% dialyzed FBS (ThermoFisher, Cat. #A3382001). Cell treatments GCN2iB (MedChemExpress, Cat. #HY-112654), mycophenolic acid (MPA) (MedChemExpress, Cat. #HY-B0421), methotrexate (MedChemExpress, Cat. #HY-14519),

(16) A cell-based chemical-genetic screen for amino acid stress response inhibitors reveals torins reverse stress kinase GCN2 signalingThe Journal of biological chemistryDecember 1, 2022Brüggenthies JB, Fiore A, Russier M, Bitsina C, Brötzmann J, Kordes S, Menninger S, Wolf A, Conti E, Eickhoff JE, et al.Merck), torin-1 (14379S, CST), torin-2 (SML1224, Sigma–Aldrich), BAY1895344 (HY-101566, MCE), GCN2iB (HY-112654, MCE), berzosertib (M6620, Sigma), RapaLink-1 (HY-111373, MCE), and everolimus (HY-10218, MCE). Ddit3

(17) Genetic and Pharmacological Inhibition of GCN2 Ameliorates Hyperglycemia and Insulin Resistance in Type 2 Diabetic MiceAntioxidants (Basel)August 16, 2022Juntao Yuan, Fang Li, Xiyue Shen, Junling Gao, Zhuoran Yu, Kai Luo, Bingqing Cui, Zhongbing LuRoche (#04693124001, #4906837001, Basel, Switzerland). GCN2iB was purchased from MedChemExpress LLC (#HY-112654, Princeton, NJ, USA). Leptin receptor-deficient mice (db/db) and HFD were obtained from HFK Bioscience

(18) Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISRCell reportsJuly 19, 2022Krokowski D, Jobava R, Szkop KJ, Chen CW, Fu X, Venus S, Guan BJ, Wu J, Gao Z, Banaszuk W, et al.(LLME) (Cayman Chemical, 16008), Puromycin (Thermo Fisher Scientific, A1113803), GCN2iB (Medchemexpress, HY-112654), ISRIB (Tocris, 5284). METHOD DETAILS Protein extraction and western blot analysis Cells were washed

(19) Inhibition of GCN2 Alleviates Cardiomyopathy in Type 2 Diabetic Mice via Attenuating Lipotoxicity and Oxidative StressAntioxidants (Basel, Switzerland)July 16, 2022Yuan J, Li F, Cui B, Gao J, Yu Z, Lu Z.Materials and Methods 2.1. Reagents and Antibodies GCN2iB was purchased from MedChemExpress LLC (#HY-112654, Monmouth-Junction, NJ, USA). Streptozotocin (STZ) and dihydroethidium (DHE) were purchased from Sigma-Aldrich

(20) Lysine Deprivation Regulates Npy Expression via GCN2 Signaling Pathway in Mandarin Fish (Siniperca chuatsi)International journal of molecular sciencesJune 16, 2022Zou JM, Zhu QS, Liang H, Lu HL, Liang XF, He S.Sigma-Aldrich (St. Louis, MO, USA). The inhibitor of GCN2 and eIF2α phosphorylation signaling, GCN2iB (HY-112654) and ISRIB (trans-isomer) (GC15462), were purchased from Med Chem Express (MCE, Monmouth Junction, NJ,

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GCN2iB from MedChemExpress

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GCN2iB from MedChemExpress

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