Apocynin from MedChemExpress

Product Specs
ItemApocynin
CompanyMedChemExpress
Price $61.00Supplier Page View Company Product Page
Catalog NumberHY-N0088
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.94%
TypeChemical
Molecular Weight166.17
FormulaC₉H₁₀O₃
Research AreaMetabolic Disease; Inflammation/Immunology

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(1) P2X7 receptors promote atrial remodeling and atrial fibrillation susceptibility via reactive oxygen species-mediated mitogen-activated protein kinase signaling activationJournal of cell communication and signalingJune 1, 2026Zhang L, Zhu Y, Gu X.with N‐acetylcysteine (NAC) (A9165, Sigma‐Aldrich) at a final concentration of 5 mM or with apocynin (HY‐N0088, MedChemExpress) at a final concentration of 10 μM. Both agents were administered 1 h prior to stimulation,

(2) Inflammation-driven mitochondrial dysfunction and ROS accumulation orchestrate pulmonary fibrotic remodeling in sepsisRedox BiolMay 16, 2026Zhaoqian Zhong, Kan Wu, Junhao Wang, Guiming Chen, Haihua Luo, Guangqin Chen, Chang Sun, Danyan Guo, Leyi Li, Lei Li, et al.N-acetylcysteine (NAC; #HY-B0215, MedChemExpress) was administered at 150 mg/kg body weight, while Apocynin (#HY-N0088, MedChemExpress) and Mito-TEMPO (#HY-112879, MedChemExpress) were administered at 20 mg/kg body weight.

(3) ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 SignalingAdvanced ScienceMarch 1, 2026Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, et al.Berberine chloride (MCE, #HY‐18258); J14 (MCE, #HY‐135008); CA‐5f (MCE, #HY‐112698); Apocynin (MCE, #HY‐N0088). 4.3 Construction of Ezrin Overexpression and Mutant Vectors Full‐length human EZRIN cDNA was seamlessly

(4) Veillonella parvula outer membrane vesicles increase ICAM-1+ neutrophils exhibiting elevated NET formation via ROS-PAD4 signalingFront Cell Infect MicrobiolJune 11, 2025Lina Xu, Yiting Jiang, Xuri Zhao, Jiabao Zhuang, Huiwen Chen, Teng Li, Zhiyan He, Wei Zhou, Zhongchen Songinhibitor GSK484 (HY-100514; MCE, Monmouth Junction, NJ, USA) at 100 nmol/L or the CYBB inhibitor apocynin (HY-N0088, MCE) at 100 μmol/L prior to stimulation with V. parvula OMVs. The experimental groups were designated

(5) Matrix stiffness regulates NPC invasiveness by modulating a mechanoresponsive TRPV4-Nox4-IL-8 signaling axisJournal of CancerJanuary 13, 2025Peng Zhang, Dunhui Yang, Kang Li, Jin Zhang, Zhen Wang, Fang Ma, Xianqin Liao, Shibo Ma, Xianhai Zeng, Xiangmin ZhangTRPV4/NOX4/IL-8 axis. Methods and Materials Drugs GSK1016790A (HY-19608), HC-067047 (HY-100208), apocynin (HY-N0088) and GLX351322 (HY-100111) were purchased from MedChemExpress. Recombinant human IL-8 was from Sigma-Aldrich.

(6) Autophagy mediated by ROS-AKT-FoxO pathway is required for intestinal regeneration in echinodermsCell Commun SignalJanuary 7, 2025Chuili Zeng, Ming Guo, Ke Xiao, Chenghua Libetween ROS, autophagy, and intestinal regeneration, Apocynin (APO, 0.1 µM, a common ROS inhibitor, Cat#HY-N0088, MedChemExpress, New Jersey, USA) was introduced to further investigate the role of ROS in autophagy

(7) NCF4 attenuates colorectal cancer progression by modulating inflammasome activation and immune surveillanceNature CommunicationsJune 17, 2024Longjun Li, Rudi Mao, Shenli Yuan, Qingqing Xie, Jinyu Meng, Yu Gu, Siyu Tan, Xiaoqing Xu, Chengjiang Gao, Hongbin Liu, et al.Table 1. Inhibitors NAC (A9165) were ordered from Sigma, PKC412 (120685), DPI (HY-100965), and APO (HY-N0088) were purchased from MedChemexpress. WT, knockout, and siRNA-transfected BMDMs were treated with inhibitors

(8) Intermittent short-duration reoxygenation relieves high-altitude pulmonary hypertension via NOX4/H2O2/PPAR-γ axisClinical ScienceFebruary 7, 2024Shaohua Li, Qiang Lyu, Qixin Shi, Yungang Bai, Xinling Ren, Jin Mainhibit different sources of ROS in rats attached to I3, MitoQ (MCE, HY-100116A) and apocynin (MCE, HY-N0088) were administered by gavage at doses of 10 mg/kg/d (MitoQ was dissolved in 0.9% NaCl solution to 3

(9) Intermittent short-duration reoxygenation relieves high-altitude pulmonary hypertension via NOX4/H2O2/PPAR-γ axisClin Sci (Lond)January 30, 2024Shaohua Li, Qiang Lyu, Qixin Shi, Yungang Bai, Xinling Ren, Jin Mainhibit different sources of ROS in rats attached to I3, MitoQ (MCE, HY-100116A) and apocynin (MCE, HY-N0088) were administered by gavage at doses of 10 mg/kg/d (MitoQ was dissolved in 0.9% NaCl solution to 3

(10) B lymphocytes transdifferentiate into immunosuppressive erythroblast-like cellsFrontiers in immunologyJanuary 1, 2023Yang Z, Wang Z, Wu L, Wang Y, Xu Z, Liu Y, Wang F, Yu D.cells were treated with 300 μM apocynin (49-hydroxy-39-methoxyacetophenone, MedChemExpress, Cat. No. HY-N0088) for 30 min in order to inhibit the activity of NADPH oxidase. For all experiments, cells were analyzed

(11) Vitamin D Receptor Activation Targets ROS-Mediated Crosstalk Between Autophagy and Apoptosis in Hepatocytes in Cholestasic MiceCellular and molecular gastroenterology and hepatologyJanuary 1, 2023Zheng Z, Xie J, Ma L, Hao Z, Zhang W, Li L.ROC), necroptosis inhibitor (Necrostatin-1, #HY-15760, 10 μmol/L; MCE), NOX1 inhibitor (apocynin, #HY-N0088, 10 μmol/L; MCE), autophagy inhibitor (chloroquine, #HY-17589A, 10 μmol/L; MCE), p38MAPK inhibitor (SB202190,

(12) mTOR contributes to endothelium-dependent vasorelaxation by promoting eNOS expression and preventing eNOS uncouplingCommunications biologyJuly 22, 2022Wang Y, Li Q, Zhang Z, Peng K, Zhang DM, Yang Q, Passerini AG, Simon SI, Sun C.N-acetylcysteine (HY-B0215), mitochondrial antioxidant MitoQ (HY-100116A), Nox inhibitor Apocynin (HY-N0088), XO inhibitor Allopurinol (HY-B0219), p38 inhibitor SB 203580 (HY-10256) and JNK inhibitor SP 600125

(13) Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammationBiochemical pharmacologyMarch 1, 2011Impellizzeri D, Esposito E, Mazzon E, Paterniti I, Di Paola R, Bramanti P, Cuzzocrea S.

(14) Apocynin: molecular aptitudesMediators of inflammationJanuary 1, 2008Stefanska J, Pawliczak R.

(15) Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catecholAmerican journal of respiratory cell and molecular biologyJuly 1, 1994Stolk J, Hiltermann TJ, Dijkman JH, Verhoeven AJ.

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Apocynin from MedChemExpress

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Apocynin from MedChemExpress

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