TMP778 from MedChemExpress | Biocompare.com

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TMP778

Description

TMP778 is a potent and selevtive RORγt inverse agonist, with an IC₅₀ of 7 nM in FRET assay

Product Specs
ItemTMP778
CompanyMedChemExpress
Price $490.00Supplier Page View Company Product Page
Catalog NumberHY-102075A
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.98%
TypeChemical
Molecular Weight494.58
FormulaC₃₁H₃₀N₂O₄
Research AreaInflammation/Immunology

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(1) Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanismsImmunityApril 17, 2014Xiao S, Yosef N, Yang J, Wang Y, Zhou L, Zhu C, Wu C, Baloglu E, Schmidt D, Ramesh R, et al.

(2) Pharmacologic inhibition of RORγt regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivoJournal of immunology (Baltimore, Md. : 1950)March 15, 2014Skepner J, Ramesh R, Trocha M, Schmidt D, Baloglu E, Lobera M, Carlson T, Hill J, Orband-Miller LA, Barnes A, et al.

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