AR7 from MedChemExpress

Product Specs
ItemAR7
CompanyMedChemExpress
Price $87.00Supplier Page View Company Product Page
Catalog NumberHY-101106
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.38%
TypeChemical
Molecular Weight257.71
Molecule NameAR7
FormulaC15H12ClNO
Research AreaNeurological Disease; Cancer

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(1) Acetylation Regulates ACSL4 Degradation Through Chaperone‐Mediated Autophagy to Alleviate Intervertebral Disc DegenerationAdvanced ScienceNovember 21, 2025Zhouwei Wu, Zhichen Jiang, Chenglong Hong, Shu Yang, Shuqing Jin, Chenyu Wu, Kaijie Guo, Jiang Liu, Shaobo Xu, Chenggui Wang, et al.10 µm CHX (Selleck, S7418) for 0–8 h. To activate CMA, HsNPCs were treated with AR7 (MedChemExpress, HY‐101106) at concentrations of 0, 20, or 50 µm for 24 h. RNA Interference and Plasmid Transfection siRNA‐mediated

(2) Chaperone-mediated autophagy degrades SERPINA1 E342K /α1-antitrypsin Z variant and alleviates cell stressAutophagyApril 1, 2025Jiayu Lin, Xinyue Wei, Yan Dai, Haorui Lu, Yajian Song, Jiansong Ju, Rihan Wu, Qichen Cao, Hao Yang, Lang RaoDMSO (Solarbo, D8371), puromycin (Solarbo, P8230), streptomycin (Solarbo, P1400), AR7 (MedChemExpress, HY-101106), QX77(MedChemExpress, HY-112483), MG-132 (MedChemExpress, HY-13259), chloroquine (MedChemExpress, HY-17589A). Molecular cloning

(3) o8G-modified circPLCE1 inhibits lung cancer progression via chaperone-mediated autophagyMol CancerMarch 17, 2025Qingyun Zhao, Dunyu Cai, Haotian Xu, Yihong Gao, Ruirui Zhang, Xiaodong Zhou, Xingcai Chen, Sixian Chen, Jiaxi Wu, Wenyi Peng, et al.× 106 cells/well); CMA activity was induced by treatment with 10 µM and 20 µM AR7 (MedChemExpress, HY-101106), and proteins were harvested after 24 h. Then, PAGE followed by western blotting was carried out to

(4) Enhanced therapeutic efficacy of anti-PD-1 blockade by targeting LAMP2A inhibits lysosomal degradation of STING and TBK1TheranosticsFebruary 18, 2025Xueying Wang, Diekuo Zhang, Jiaqing Xiao, Lei Wang, Junrong Wang, Xiaoqiao Cui, Jiaqi Tan, Yong Liu, Susheng MiaoSelleck), and CHX (cycloheximide, S7418, Selleck), AKTi-1/2(AKT inhibitor VIII, HY-10355, MCE), AR7 (HY-101106, MCE), Rapamycin(553210, Sigma), D-Luciferin Sodium Salt (40901ES, Yeasen, China), C-176(SML2559, Sigma),

(5) Impaired degradation of PLCG1 by chaperone-mediated autophagy promotes cellular senescence and intervertebral disc degenerationAutophagySeptember 10, 2024Zhangrong Cheng, Weikang Gan, Qian Xiang, Kangcheng Zhao, Haiyang Gao, Yuhang Chen, Pengzhi Shi, Anran Zhang, Gaocai Li, Yu Song, et al.3-MA (MedChemExpress, HY-19312) for 3–12 h to inhibit macroautophagy activity. AR7 (MedChemExpress, HY-101106) and QX77 (Selleck, S6797) were used to activate CMA. 3CAI (MedChemExpress, HY-16666) was used to inhibit

(6) Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteomeCellMay 13, 2021Bourdenx M, Martín-Segura A, Scrivo A, Rodriguez-Navarro JA, Kaushik S, Tasset I, Diaz A, Storm NJ, Xin Q, Juste YR, et al.

(7) Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA)AutophagyFebruary 1, 2020Ho PW, Leung CT, Liu H, Pang SY, Lam CS, Xian J, Li L, Kung MH, Ramsden DB, Ho SL.

(8) Chemical modulation of chaperone-mediated autophagy by retinoic acid derivativesNature chemical biologyJune 1, 2013Anguiano J, Garner TP, Mahalingam M, Das BC, Gavathiotis E, Cuervo AM.

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