SAG from MedChemExpress

Product Specs
ItemSAG
CompanyMedChemExpress
Price $129.00Supplier Page View Company Product Page
Catalog NumberHY-12848
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.79%
TypeChemical
Molecular Weight490.06
Molecule NameSAG
FormulaC28H28ClN3OS
Research AreaCancer

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(1) Dahuang Zhechong pill alleviates pulmonary fibrosis by inhibiting apoptosis and epithelial-mesenchymal transition of type II alveolar epithelial cells in vitro and in vivoJournal of Traditional and Complementary MedicineMarch 1, 2026Fang Sun, Zhaochu Wu, Song Cai, Xiaoming Xing, Jing Wang, Lishan ZhangBeyotime Biotechnology Co., Ltd. (Shanghai, China). DMOG (#HY-15893), TGF-β1 (#HY-P70543), and SAG (#HY-12848) were purchased from MCE, USA. The following antibodies were purchased from Shanghai Abcam Trading Co.,

(2) Fibrotic scar formation after cerebral ischemic stroke: Targeting the Sonic hedgehog signaling pathway for scar reductionNeural regeneration researchFebruary 1, 2026Wen J, Tang H, Tian M, Wang L, Yang Q, Zhao Y, Li X, Ren Y, Wang J, Zhou L, et al.(multiplicity of infection = 100) or SAG (a potent agonist of the Shh signaling pathway; 0.25 µM, MCE, HY12848) for 3 days with or without SIS3 (10 µM). Cells were pre-treated with SRI-011381 (10 µM) for 3 days. Culture

(3) Recapitulation of endochondral ossification by hPSC-derived SOX9+ sclerotomal progenitorsNat CommunMarch 21, 2025Jingfei Xiong, Runxin Ma, Kun Xie, Ce Shan, Hanyi Chen, Yuqing Wang, Yuansong Liao, Yanhui Deng, Guogen Ye, Yifu Wang, et al.centrifugation again at 300 g for 3 min and resuspended in CDMi supplemented with SAG (200 nM, MCE, Cat#HY-12848), LDN193189 (600 nM), XAV939 (0.5 μM, MCE, Cat#HY-15147), and Y27632 (10 μM) for the following SOX9+

(4) Saponins enhance the stability and cost-efficiency of human embryonic stem cell cultureCell regeneration (London, England)January 21, 2025Shi J, Wu M, Fang S, Liu Z, Liu H, Zhao Y, Liu L, Shao Z.containing LDN193189 (100 nM), SB431542 (10 nM), IWP2 (10 nM, MCE, HY13912), and SAG (100 nM, MCE, HY12848) from day 0 to day 7. ROCK inhibitor Y27632 was again used to aid cell survival during the initial days

(5) A Chemically Defined Culture for Tooth ReconstitutionAdvanced ScienceNovember 27, 2024Ziwei Zhang, Hong Hu, Zhiheng Xu, Ce Shan, Hanyi Chen, Kun Xie, Kun Wang, Yifu Wang, Qing Zhu, Yike Yin, et al.(10 ng·mL−1, Solarbio, Cat# P00101), CHIR99021 (3 µm, MCE, Cat# HY‐10182) and SAG (200 nm, MCE, Cat# HY‐12848) into the 24‐well culture plates pre‐treated by 2% w/v PolyHEMA. The first branchial arches were kept

(6) Deciphering colorectal cancer radioresistance and immune microrenvironment: unraveling the role of EIF5A through single-cell RNA sequencing and machine learningFrontiers in ImmunologySeptember 3, 2024Yaqi Zhong, Xingte Chen, Shiji Wu, Huipeng Fang, Liang Hong, Lingdong Shao, Lei Wang, Junxin WuDM2500). Image Pro advanced software was used to analyze the mean fluorescence intensity (MFI). SAG (HY-12848, MedChemExpress, USA), as the agonist of Hedgehog pathway, was used for the rescue experiment of Hedgehog

(7) Effective cryopreservation of human brain tissue and neural organoidsCell Rep MethodsMay 20, 2024Xue W, Li H, Xu J, Yu X, Liu L, Liu H, Zhao R, Shao Z.A100188 Sucrose,Guoyao,Cat# 10021463 Dimethyl sulfoxide,Sigma-Aldrich,Cat# D8418 SAG,MedChemExpress,Cat# HY-12848 Matrigel,Corning,Cat# 356230 EGF,R&D Systems,Cat# 236-EG-200 FGF,PeproTech,Cat# AF-100-18B FGF8,PeproTech,Cat#

(8) Modeling the precise interaction of glioblastoma with human brain region-specific organoidsiScienceMarch 15, 2024Fan Q, Wang H, Gu T, Liu H, Deng P, Li B, Yang H, Mao Y, Shao Z.proteins","Chemicals, peptides, and recombinant proteins" ,, IWP2,Sigma-Aldrich,Cat# I0536 SAG,MedChemExpress,Cat# HY-12848 FGF8,PeproTech,Cat# PHG0184 LDN193189,MedChemExpress,Cat# HY-12071 SB431542,MedChemExpress,Cat# HY-10431 FGF2,PeproTech,Cat#

(9) Yap controls notochord formation and neural tube patterning by integrating mechanotransduction with FoxA2 and Shh expressionScience AdvancesJune 16, 2023Caiqi Cheng, Qian Cong, Yuchen Liu, Yizhong Hu, Guoyan Liang, Kevin Marc Manquiquis Dioneda, Yingzi YangShh RNA probes have been described previously (83). Small-molecule treatment SAG (MedChemExpress, HY-12848) was diluted in 10% dimethyl sulfoxide and then mixed with corn oil. SAG was injected intraperitoneally

(10) Generation of dorsoventral human spinal cord organoids via functionalizing composite scaffold for drug testingiScienceJanuary 20, 2023Xue W, Li B, Liu H, Xiao Y, Li B, Ren L, Li H, Shao Z.and UV irradiation for sterilization. Approximately 30–40 PCSM and 10 μL small molecule SAG (0.5 mM) (HY-12848, MCE) were gently mixed on ice and stored at 4°C for 12 h. Then, 40 μL Matrigel (356230, Corning) added

(11) Whole-exome sequencing identified novel variants in CPLANE1 that causes oral-facial-digital syndrome Ⅵ by inducing primary cilia abnormalityJournal of cellular and molecular medicineJune 1, 2022Qian W, Liu X, Wang Z, Xu Y, Zhang J, Li H, Zhong Q, Li C, Zhu L, Zhou Z, et al.NIH/3T3 cells. Twenty‐four hours after transfection, 40 μL of 100 μmol/L SAG (final concentration: 4 μmol/L, HY‐12848, MCE, USA) was added to the 6‐well plate, and the plate was incubated for 48 h. RNA and protein were

(12) Inhibition of smoothened in breast cancer cells reduces CAXII expression and cell migrationJournal of cellular physiologyDecember 1, 2018Guerrini G, Criscuoli M, Filippi I, Naldini A, Carraro F.

(13) Combining Smoothened Agonist and NEL-Like Protein-1 Enhances Bone HealingPlastic and reconstructive surgeryJune 1, 2017Lee S, Wang C, Pan HC, Shrestha S, Meyers C, Ding C, Shen J, Chen E, Lee M, Soo C, et al.

(14) Preaxial polydactyly following early gestational exposure to the smoothened agonist, SAG, in C57BL/6J miceBirth defects researchJanuary 20, 2017Fish EW, Parnell SE, Sulik KK, Baker LK, Murdaugh LB, Lamson D, Williams KP.

(15) A small molecule that binds Hedgehog and blocks its signaling in human cellsNature chemical biologyMarch 1, 2009Stanton BZ, Peng LF, Maloof N, Nakai K, Wang X, Duffner JL, Taveras KM, Hyman JM, Lee SW, Koehler AN, et al.

(16) Small molecule modulation of Smoothened activityProceedings of the National Academy of Sciences of the United States of AmericaOctober 29, 2002Chen JK, Taipale J, Young KE, Maiti T, Beachy PA.

(17) [Very long term remissions in acute leukemias of children (study of 6 cases)]Marseille medicalJanuary 1, 1971Massimo L, Mori BJ, Orsini A, Raybaud C, Cottafava F, Perrimond H.

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