Org-12962 from MedChemExpress | Biocompare.com

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Org-12962

Description

Org-12962 is a potent, selective and orally active 5-HT_2C receptor agonist with a pEC₅₀ value of 7.01. Org-12962 also exhibits high effacy for the 5-HT_2A and 5-HT_2B receptor with pEC₅₀s of 6.38 and 6.28, respectively.Org-12962 displays antiaversive effects in a rat model of panic-like anxiety

Product Specs
ItemOrg-12962
CompanyMedChemExpress
Price $55.00Supplier Page View Company Product Page
Catalog NumberHY-118152
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.93%
TypeChemical
Molecular Weight265.66
FormulaC₁₀H₁₁ClF₃N₃
Research AreaNeurological Disease

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(1) Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugsInternational journal of pharmaceuticsSeptember 16, 2003Faassen F, Vogel G, Spanings H, Vromans H.

(2) Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cellsBritish journal of pharmacologySeptember 1, 1999Porter RH, Benwell KR, Lamb H, Malcolm CS, Allen NH, Revell DF, Adams DR, Sheardown MJ.

(3) [Extramedullary relapse in the external auditory canal in a patient with acute promyelocytic leukemia treated with all-trans retinoic acid and autologous peripheral blood stem cell transplantation][Rinsho ketsueki] The Japanese journal of clinical hematologySeptember 1, 1998Yagita M, Onishi R, Yamagata N, Shimazaki C, Kudoh H, Kobayashi M, Hikiji K, Konaka Y.

(4) Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in ratsEuropean neuropsychopharmacology : the journal of the European College of NeuropsychopharmacologyAugust 1, 1998Jenck F, Moreau JL, Berendsen HH, Boes M, Broekkamp CL, Martin JR, Wichmann J, Van Delft AM.

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