Seclidemstat from MedChemExpress

Description

Seclidemstat is a potent noncompetitive and reversible KDM1A (LSD1) inhibitor (K_i=31 nM, IC₅₀=13 nM). Seclidemstat promotes antitumor immunity in switch/sucrose nonfermentable (SWI/SNF) complex mutated ovarian cancer, as well as inhibit virus production, viral DNA replication, and late gene expression. Seclidemstat can be used for the research of Ewing Sarcoma

Product Specs
ItemSeclidemstat
CompanyMedChemExpress
Price $55.00Supplier Page View Company Product Page
Catalog NumberHY-103713
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.77%
FormulaC20H23ClN4O4S
Research AreaCancer
TypeChemical
Molecular Weight450.94
Quantity10 mM * 1 mL
Molecule NameSeclidemstat

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(1) LSD1 inhibition attenuates targeted therapy-induced lineage plasticity in BRAF mutant colorectal cancerMol CancerApril 23, 2025Christopher A. Ladaika, Averi Chakraborty, Ashiq Masood, Galen Hostetter, Joo Mi Yi, Heather M. O'Hagan#HY-50895), Stattic (Selleckchem #S7024), and SP-2577 mesylate (Seclidemstat mesylate; MedChemExpress #HY-103713 A) were solubilized in DMSO (VWR #97063-136) prior to treatment. Pharmaceutical grade cetuximab was

(2) YAP/TAZ drives cell proliferation and tumour growth via a polyamine-eIF5A hypusination-LSD1 axisNature cell biologyMarch 1, 2022Li H, Wu BK, Kanchwala M, Cai J, Wang L, Xing C, Zheng Y, Pan D.either vehicle (10% DMSO + 45% saline + 40% PEG300 + 5% Tween-80) or 50 mg/kg body weight SP-2577 (Cat# HY-103713, MedChemExpress) through i.p. administration once daily. Tumor size was measured every 3 days. Tumor volume

(3) Comprehensive in Vitro Characterization of the LSD1 Small Molecule Inhibitor Class in OncologyACS pharmacology & translational scienceDecember 10, 2021Sacilotto N, Dessanti P, Lufino MMP, Ortega A, Rodríguez-Gimeno A, Salas J, Maes T, Buesa C, Mascaró C, Soliva R.vendors: compounds 2, 5, 6, and 9 (MedChemExpress, refs. HY-B1018A (2), HY-12635 (5), HY-129388B (6), and HY-103713 (9)), 1 (Selleckchem, ref. S4246), and 3 (Sigma-Aldrich, ref. P8013). Compounds 4 (OG-668), 7 (GSK-2879552),

(4) Reversible Lysine Specific Demethylase 1 (LSD1) Inhibitors: A Promising Wrench to Impair LSD1Journal of medicinal chemistryMarch 11, 2021Dai XJ, Liu Y, Xue LP, Xiong XP, Zhou Y, Zheng YC, Liu HM.

(5) The novel reversible LSD1 inhibitor SP-2577 promotes anti-tumor immunity in SWItch/Sucrose-NonFermentable (SWI/SNF) complex mutated ovarian cancerPloS oneJanuary 1, 2020Soldi R, Ghosh Halder T, Weston A, Thode T, Drenner K, Lewis R, Kaadige MR, Srivastava S, Daniel Ampanattu S, Rodriguez Del Villar R, et al.

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Seclidemstat from MedChemExpress

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Seclidemstat from MedChemExpress

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