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Protein Biochemistry
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Simurosertib
Simurosertib from MedChemExpress
Be the first to write a review!
Citations:
(4)
Supplier Page
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MedChemExpress for
Simurosertib
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Description
Simurosertib (TAK-931) is an orally active, selective and ATP-competitive
cell division cycle 7 (CDC7)
kinase inhibitor, with an
IC
50
of <0.3 nM. Simurosertib has anti-cancer activity
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
Simurosertib
Company
MedChemExpress
Price
$244.00
Supplier Page
View Company Product Page
Catalog Number
HY-100888
Quantity
10 mM * 1 mL
Applications
Bioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity
99.94%
Type
Chemical
Molecular Weight
341.43
Formula
C₁₇H₁₉N₅OS
Research Area
Cancer
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MedChemExpress
1 Deer Park Drive, Suite F
MONMOUTH JUNCTION
,
NJ
08852
United States
Phone
: US Tel: 609-228-6898
US Fax: 609-228-5909
EU Tel: +4686500910
Email: sales@medchemexpress.com
eu.sales@MedChemExpress.com
Company Profile
Website:
medchemexpress.com
Citations (4)
(1)
Cyclin E modulates vulnerability to CDC7 kinase inhibition
Oncogenesis
April 24, 2026
Adam P. Dommer, Robert Kyne, Jianxin Wang, Thomas N. O’Connor, Amnon Koren, Erik S. Knudsen, Agnieszka K. Witkiewicz
mediated by cyclin E portends CDC7 inhibitor
sensitivity
. Materials and Methods Compounds TAK-931 (
HY-100888
, 2 mg), XL-413 Monohydrochloride (
HY-15260A
, 5 mg), and
BI-1347
(
HY-120350
, 5 mg) were obtained from
(2)
CDC7 is a targetable regulator of advanced prostate cancer
Sci Rep
December 18, 2025
Alifiani B. Hartono, HyeonJi Hwang, Sidharth Paparaju, Shiqin Liu, James D. Brooks, Eva Corey, Tanya Stoyanova
for
mycoplasma
contamination by
PCR
-based assay55. TAK-931 was purchased from
MedChemExpress
(cat #
HY-100888
). Generation of
CDC7
-KD cells Viral particles were generated by transfecting lentiviral vectors and
(3)
Minichromosome maintenance proteins in lung adenocarcinoma: Clinical significance and therapeutic targets
FEBS open bio
September 1, 2023
Tanigawa K, Tomioka Y, Misono S, Asai S, Kikkawa N, Hagihara Y, Suetsugu T, Inoue H, Mizuno K, Seki N.
media were discarded, and the cells were treated with different concentrations of TAK‐931 (catalog no.:
HY‐100888
/CS‐0020550;
MedChemExpress
, NJ, USA) ranging from 1 to 1000 nm. The plates were incubated for 5 days,
(4)
CDC7 kinase (DDK) inhibition disrupts DNA replication leading to mitotic catastrophe in Ewing sarcoma
Cell death discovery
February 26, 2022
Martin JC, Sims JR, Gupta A, Hagoel TJ, Gao L, Lynch ML, Woloszynska A, Melendy T, Kane JF, Kuechle J,
et al
.
The CDC7 kinase
inhibitor
TAK-931 (
Simurosertib
) was purchased from MedChemExpress (
MCE
) (cat. No.
HY-100888
) as a 10 mM stock dissolved in DMSO. Cell viability Cells were seeded at appropriate densities (adherent
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Simurosertib from MedChemExpress
Supplier Page
View Company Product Page
$244.00
Product Specs
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Reviews
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