SC79 from MedChemExpress

Product Specs
ItemSC79
CompanyMedChemExpress
Price $66.00Supplier Page View Company Product Page
Catalog NumberHY-18749
Quantity5 mg
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity98.0%
TypeChemical
Molecular Weight364.78
FormulaC₁₇H₁₇ClN₂O₅
Research AreaNeurological Disease; Inflammation/Immunology; Cancer

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(1) Hepatotoxic Mechanisms of Polyethylene Terephthalate Microplastics Revealed by Network Toxicology, Molecular Docking, and In Vivo ValidationInt J Mol SciApril 3, 2026Xuemei Tan, Min Zhang, Jingying Lu, Shuo Shi, Xueting Shi, Zhouhua Houantibodies (Bax, Bcl2, Cleaved-Caspase-3, P-AKT, AKT, ACTIN) were used at a dilution of 1:1000. SC79 (HY-18749) and LY294002 (HY-10108) were purchased from MedChemExpress (Monmouth Junction, NJ, USA). 4.8. Cell Culture

(2) Reduced cartilage matrix stiffness in temporomandibular joint osteoarthritis impairs the functions of superficial zone chondrocytes via downregulation of CREB5-PLPP3 signalingMol BiomedMarch 23, 2026Yeke Yu, Dongsheng Wen, Luxiang Zou, Huimin Zhu, Xiaoyu Zhang, Chuandong Wang, Chuan Lu, Jieyun Zhao, Yifan Zhang, Dongmei He, et al.AKT (Fig. 5b). The specific AKT activator, SC-79 [46], with the concentration of 4 µg/mL (MCE, CAT: HY-18749, LOT: 517,547), restored the expression of p-AKT and promoted the fibronectin and PRG4 expression in

(3) Endothelial Nitric Oxide Synthase Restores Diabetic Dentin Regeneration via AKT/Endothelial Nitric Oxide Synthase AxisInt Dent JMarch 19, 2026Xuanhe Feng, Liang Hu, Chen Zhang, Wanzhen Lei, Bowen Zhou, Dengsheng Xia, Zhaochen Shan, Luyuan Jinlevels of p-AKT and eNOS in hDPSCs (Figures 3D-F). However, when treated with the AKT activator SC79 (HY-18749, MCE, China), the levels of p-AKT and eNOS were partially restored under high-glucose conditions. Inhibition

(4) CD93-targeted resveratrol-loaded PLGA nanoparticles remodel CD8⁺ T cell metabolism through AIF-mediated oxidative phosphorylation to overcome lung cancer immunotherapy resistanceJournal of NanobiotechnologyMarch 14, 2026Zhou Jiang, Yuning LiSC-79 group (CD93 overexpression combined with AKT activator treatment group). SC-79 (2 µg/mL, 1 h, HY-18749, MedChemExpress, USA) is a specific activator of AKT. (3) CON group, CD93-NPs@RSV group, Free RSV group,

(5) Eccentric treadmill training and skeletal muscle immunometabolic responses in HFD-induced insulin resistanceFrontiers in ImmunologyFebruary 25, 2026Wei Luo, Yuanyuan Wang, Siyi He, Shijin Zhao, Yue Zhou, Lei AiL-glucose was used in Con group for the high glucose as an osmotic control for 60 mmol/L D-glucose. SC79 (HY-18749, MCE, USA) and MK2206 (HY-10358, MCE, USA) were used as a specific AKT agonist and inhibitor, respectively.

(6) Triptonide Suppresses AML via PI3K/AKT Signaling: A Network Pharmacology Approach Validated by Molecular Docking and Experimental StudiesCurrent Issues in Molecular BiologyFebruary 24, 2026Lixia Song, Jing Meng, Huijie Li, Wanxin Fu, Kun Hong, Shengnan Shen, Zheping Zhang, Shilan Ding, Shengpeng Li, Zifan Zhang, et al.concentrations of 0, 10, 20, and 40 nM for 72 h, with or without co-treatment of the AKT agonist SC79 (HY-18749, MCE, Shanghai, China). Subsequently, Western blot analysis was performed to assess protein expression

(7) Thrombospondin 1 aggravates cardiac remodeling in heart failure with preserved ejection fraction by inhibiting mitophagyiScienceFebruary 20, 2026Xingpeng Bu, Shuo Sha, Zhenzhen Zhang, Sicheng Bian, Shuhui Feng, Chunxia Li, Lei Wang, Huanzhen Chencells with 10 μM LY294002 (PI3K inhibitor; HY-10108, MedChemExpress) or 10 μM SC79 (an Akt activator; HY-18749, MedChemExpress) for 1 h before stimulation. For gene manipulation, Thbs1 expression was modulated by

(8) Role of albumin in regulating platelet functionFrontiers in PharmacologyFebruary 20, 2026Qiwen Tai, Mengnan Yang, Shuang Chen, Yue Xia, Chenglin Sun, Lili Zhao, Kangxi Zhou, Pixia Gong, Jie Shen, Qiuxia Huang, et al.(HY-18739), PKC activator PDBu (HY-18985), Akt activator 740Y-P (HY-P0175), and Akt activator SC79 (HY-18749) were acquired from MedChemExpress (Monmouth Junction, NJ, United States). Mouse serum albumin (SEKM-0297),

(9) TREM2 Facilitates Myelin Debris Clearance but Exacerbates Chronic Inflammation and Fibrosis After Spinal Cord InjuryCNS Neurosci TherFebruary 9, 2026Zhonghan Wu, Shuisheng Yu, Yixue Hu, Xuyang Hu, Linhan Yang, Yan Jiang, Mengdi Zhang, Yiyang Mu, Ziyu Li, Fei Yao, et al.models of Alzheimer's disease (AD), ischemic stroke (IS), and SCI [18, 19, 20]. For in vivo use, SC79 (HY‐18749, MedChemExpress, Monmouth Junction, NJ, USA) was dissolved in 5% dimethyl sulfoxide (DMSO; HY‐Y0320C,

(10) Hepatocyte-Specific MET Deletion Exacerbates Acetaminophen-Induced Hepatotoxicity in MiceThe American Journal of PathologyFebruary 1, 2026Siddhi Jain, Ranjan Mukherjee, Gillian Williams, Jia-Jun Liu, Lanuza A.P. Faccioli, Zhiping Hu, Rodrigo M. Florentino, George K. Michalopoulos, Alejandro Soto-Gutierrez, Silvia Liu, et al.aggravated JNK activation and liver injury in MET KO mice, an AKT activator (SC79: 10 mg/kg, i.p.) (#HY-18749; MedChemExpress, Monmouth Junction, NJ) was used in the MET KO mice. SC79 or its vehicle (4% dimethyl

(11) Paroxetine as a Therapeutic Agent in Inflammatory Osteolysis: Mechanistic Insights and EfficacyDrug Design, Development and TherapyJanuary 27, 2026Junming Huang, Zhipeng Wang, Jun Liu, Jihong Zhang, Kui Deng, Shanhu Huang, Song Zhouand M-CSF (416-ML-010) were obtained from Bio-Techne (Minneapolis, MN). Paroxetine (HY-122272), SC79 (HY-18749), 740 Y-P (HY-P0175), and DMSO (dimethyl sulfoxide) (DMSO, HY-Y0320) were purchased from MedChemExpress

(12) HMBOX1 inhibits hepatocellular carcinoma progression via PTPN1 mediated AKT1 phosphorylationOncology ReportsJanuary 19, 2026Chenning Zhang, Yu Jiang, Jiahui Liu, Wenyu Zhang, Jie Qi, Qing Wen, Hengli Zhao37°C and 5% CO2 in a cell culture incubator. In some experiments, the Akt activator SC79 (cat. no. HY-18749; MedChemExpress) at a concentration of 4 µΜ was used to treat Hepa1-6 cells for different times. All

(13) Lactate attenuates hepatic ischemia-reperfusion injury by reducing intrahepatic Inflammation and suppressing hepatocyte-neutrophil interaction via the IL-33/ST2 pathwayCell Communication and SignalingJanuary 15, 2026Peiyang Fang, Zihan Zhang, Jingjing Zhu, Haozhe Xu, Xiaotong Han, Nan Xu, Xiyu Wang, Longyang Zhou, Xiaonan Du, Hua Jin, et al.of 20 mM sodium lactate, 2.5 µM p-AKT inhibitor MK2206 (HY-108232, MCE), 10 µM p-AKT agonist SC79 (HY-18749, MCE), 5 ng/mL TGF-β1 (HY-P7117, MCE), PDGF-BB (HY-P7087, MCE), 25 ng/mL IL-1β (HY-P7073, MCE), 20 ng/mL

(14) An innovative in vitro system unveils IGF1R signaling regulating Merkel cell generationStem Cell ReportsJanuary 13, 2026Huipu Yuan, Chen Rui, Yajun Zhang, Jun Liu, Yanghui He, Xia Wu, Tuan Wang, Zhengduo Zhang, Chaochen Wang, Ying Xiaococktail (PRCi), the FGFR2i infigratinib, the IGF1R inhibitor (BMS-754807), or with the AKT agonist SC79 (HY-18749) (all from MCE). The PRCi was a mixture of EED226 (HY-101117), PRT4165 (HY-19817), and GSK126 (HY-13470).

(15) CGR11 promotes hepatocellular carcinoma progression by regulating autophagy through the PI3K/AKT pathwayFrontiers in Cell and Developmental BiologyJanuary 7, 2026Jia Zhou, Sulai Liu, Yinghui Song, Junjie Liu, Zhiguo Tan, Jie Liu, Xiaoxia Han, Yang Xing, Xinrun Wang, Chuang Peng, et al.and 1% penicillin-streptomycin (Biosharp, BL505A) at 37 °C with 5% CO2. MK2206 (#HY-10358) and SC79 (#HY-18749) were purchased from MedChemExpress and dissolved in DMSO at 5 μM and 4 μM, respectively. 2.9 Western blot analysis

(16) Vitamin D promotes apoptosis and enhances cisplatin sensitivity in bladder cancer cells by inhibiting the Warburg effect through the AKT/mTOR pathwayBMC UrologyDecember 15, 2025Jian Zhou, Chaoyang Zhang, Xiao Wang, Ji Xing, Geng Cheng, Hao Chumaterials and reagents VD (HY-10002), DDP (HY-17394), pyruvic acid sodium (PAS; HY-W015913), and SC79 (HY-18749) were purchased from MedChemExpress (New Jersey, US). RPMI-1640 (SH30809.01B) was purchased from HyClone

(17) Extracellular vesicles from Yiguanjian-primed bone-marrow mesenchymal stem cells ameliorate chronic liver fibrosis via miR-7045-5pStem Cell Research & TherapyNovember 26, 2025Zhejun Liu, Xiaodan Jiang, Hongjie You, Zuoqing Tang, Yun Ma, Niancong Che, Chongyang Ma, Wenlan Liuweeks), as well as Akt-agonist and Akt-inhibitor groups (received 10 mg/kg SC79 [MCE, China; Cat No. HY-18749] and 50 mg/kg Akt inhibitor VIII [MCE, China; Cat No. HY-10355)], respectively, via intraperitoneal

(18) TRIM36 inhibits lung fibroblast activation and pulmonary fibrosis through the degradation of phospho-AKT1iScienceNovember 21, 2025Yajun Li, Yuexia Yang, Yingjie Wang, Feifan Shi, Yue Zhang, Hongzhi Wen, Xin Pan, Cong Xia, Zhongzheng Li, Kaisa Cui, et al.ST551 MG132,MedChemExpress,Cat# HY-13259 MK-2206,MedChemExpress,Cat# HY-10358 SC79,MedChemExpress,Cat# HY-18749 Cycloheximide,MedChemExpress,Cat# HY-12320 IPTG,Sigma-Aldrich,Cat# I5502 Lipo3000,Thermofisher,Cat#

(19) SENP3 mediated DeSUMOylation of macrophage derived CCL17 accelerates atherosclerosis via regulation of TregCell Biology and ToxicologyNovember 21, 2025Xiliang Zhao, Fenfang Zhang, Jianjun Du, Yaodong Ding, Yang Zhang, Yong Zeng, Yicong YeSanger sequencing. The autophagy inhibitor 3-Methyladenine (3MA; HY-19312) and AKT activator SC79 (HY-18749) were bought from MCE (MA, USA). Ox-LDL was bought from Shanghai Yeasen. Triglyceride (TG) Colorimetric

(20) Single-cell transcriptomics uncovering a critical AKT-LONP1-STAR axis in ovarian hyperandrogenism of PCOSJournal of Ovarian ResearchNovember 19, 2025Chunren Zhang, Zengxian Lin, Yuehui Lin, Hongxia Maat a density of 3 × 10^5 cells, with over 80% cell viability observed the following day. SC79 (MCE HY-18749, an Akt agonist) was administered, and proteins were collected after 48 h of treatment at different

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