Ritonavir-d6 from MedChemExpress | Biocompare.com

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Ritonavir-d6

Description

Ritonavir-d₆ is the deuterium labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC₅₀ of 1.61 µM

Product Specs
ItemRitonavir-d6
CompanyMedChemExpress
Price $1,150.00Supplier Page View Company Product Page
Catalog NumberHY-90001S
Quantity1 mg
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
TypeChemical
Molecular Weight726.98
FormulaC₃₇H₄₂D₆N₆O₅S₂
Research AreaInfection
Purity98.84%

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(1) Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like proteaseSignal transduction and targeted therapyMay 29, 2021Sun Q, Ye F, Liang H, Liu H, Li C, Lu R, Huang B, Zhao L, Tan W, Lai L.

(2) Impact of Deuterium Substitution on the Pharmacokinetics of PharmaceuticalsThe Annals of pharmacotherapyFebruary 1, 2019Russak EM, Bednarczyk EM.

(3) HIV-1 protease inhibitor ritonavir modulates susceptibility to apoptosis of uninfected T cellsJournal of human virologySeptember 1, 1999Weichold FF, Bryant JL, Pati S, Barabitskaya O, Gallo RC, Reitz MS Jr.

(4) Potent inhibition of the cytochrome P-450 3A-mediated human liver microsomal metabolism of a novel HIV protease inhibitor by ritonavir: A positive drug-drug interactionDrug metabolism and disposition: the biological fate of chemicalsAugust 1, 1999Kumar GN, Dykstra J, Roberts EM, Jayanti VK, Hickman D, Uchic J, Yao Y, Surber B, Thomas S, Granneman GR.

(5) HIV protease inhibitor ritonavir: a more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ PSC 833Biochemical pharmacologyMay 15, 1999Drewe J, Gutmann H, Fricker G, Török M, Beglinger C, Huwyler J.

(6) Differential inhibition of cytochrome P450 isoforms by the protease inhibitors, ritonavir, saquinavir and indinavirBritish journal of clinical pharmacologyAugust 1, 1997Eagling VA, Back DJ, Barry MG.

(7) Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomesThe Journal of pharmacology and experimental therapeuticsApril 1, 1996Kumar GN, Rodrigues AD, Buko AM, Denissen JF.

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