(R)-GNE-140 from MedChemExpress

Product Specs
Item(R)-GNE-140
CompanyMedChemExpress
Price $220.00Supplier Page View Company Product Page
Catalog NumberHY-100742A
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.77%
TypeChemical
Molecular Weight499.04
FormulaC₂₅H₂₃ClN₂O₃S₂
Research AreaCancer

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(1) Single-cell atlas of hepatitis C virus inoculated tree shrew liver reveals immune activation, metabolic reprogramming, and persistent inflammationeBioMedicineJanuary 1, 2026Dandan Yu, Wei-Bo Kang, Yu-Hua Ma, Long-Bao Lv, Shihua Zhang, Lei Tang, Sheng Liu, Jin Zhong, Yong-Gang Yaotreated with either 2 mM 2-deoxy-d-glucose (2-DG; HY-13966, MedChemExpress) or R-GEN-140 (5 or 15 μM; HY-100742A, MedChemExpress) following the 6 h infection period, and incubated under these conditions until harvest. Quantification

(2) Mesenchymal Stem Cell‐Derived Extracellular Vesicles Modulate the Course of Peritoneal Inflammation Through Metabolic and Epigenetic RegulationAdvanced ScienceJanuary 1, 2026Qiang Huang, Yuxiang Sun, Pengpeng Kuang, Juan Sun, Dandan Guo, Long Peng, Hu Zhou, Qinrong Song, Zhihao Huo, Canming Li, et al.lactate metabolism studies, age‐matched C57BL/6 mice were allocated into: Saline, CG, CG + GNE‐140 (MCE, HY‐100742A) (LDHA inhibitor, 5 µg g−1 body weight, intraperitoneal administration, three times weekly from day

(3) Impaired mitochondrial metabolism is a critical cancer vulnerability for MYC inhibitorsSci AdvJuly 18, 2025William Yang, Qianyu Guo, Songhua Quan, Zachary R. Chalmers, J. Brandon Parker, Mihai Truica, Mary F. Dufficy, Megan M. Kerber, Karthik Vasan, Dikshat G. Gupta, et al.dissolved in sterile water. For pyruvate metabolism studies, R-GNE-140 (LDHA inhibitor, MedChemExpress, no. HY-100742A), CPI-613 (PDH inhibitor, MedChemExpress, no. HY-15453), and PC-IN-1 (pyruvate carboxylase inhibitor,

(4) Lysine L-lactylation is the dominant lactylation isomer induced by glycolysisNature chemical biologyJanuary 1, 2025Zhang D, Gao J, Zhu Z, Mao Q, Xu Z, Singh PK, Rimayi CC, Moreno-Yruela C, Xu S, Li G, et al.and (R)-(−)-MTPA-Cl (65363) were purchased from MilliporeSigma; POMHEX (HY-131904) and (R)-GNE-140 (HY-100742A) were purchased from MedChemExpress; [13C6,15N2]-vitamin B5 (no. 5065) was purchased from Isosciences;

(5) Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastomaImmunityMay 14, 2024De Leo A, Ugolini A, Yu X, Scirocchi F, Scocozza D, Peixoto B, Pace A, D'Angelo L, Liu JKC, Etame AB, et al.,Thermo Fisher Scientific,Cat#N13195 2-DEOXY-D-GLUCOSE,Sigma Aldrich,Cat#D8375 (R)-GNE-140,MEDCHEMEXPRESS,Cat#HY-100742A CPI-1612,MEDCHEMEXPRESS,Cat#HY-136285 BMS-303141,MEDCHEMEXPRESS,Cat#HY-16107 THAPSIGARGIN,Fisher Scientific

(6) Forward Genetic Screens Identify Mechanisms of Resistance to Small-Molecule Lactate Dehydrogenase InhibitorsACS Chemical BiologyFebruary 16, 2024Anderson R. Frank, Florentina Vandiver, David G. McFadden(MLN4924 (ApexBio B10356), Bortezomib (Selleck S1013), CD437 (Sigma C5865), (R)-GNE-140 (MedChemExpress HY-100742A), and NCGC00420737 (kindly provided by Gordon M. Stott and the NCI Experimental Therapeutics Program)

(7) Metabolic control of histone acetylation for precise and timely regulation of minor ZGA in early mammalian embryosCell discoverySeptember 27, 2022Li J, Zhang J, Hou W, Yang X, Liu X, Zhang Y, Gao M, Zong M, Dong Z, Liu Z, et al.treatment, we prepared solutions of FK866 (HY-50876; MedChemExpress, Monmouth Junction, NJ, USA), GEN-140 (HY-100742A; MedChemExpress), Oxamate (C3893; ApexBio, Houston, TX, USA) and TSA (T8552; Sigma, St. Louis, MO, USA)

(8) Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in MiceACS medicinal chemistry lettersOctober 13, 2016Purkey HE, Robarge K, Chen J, Chen Z, Corson LB, Ding CZ, DiPasquale AG, Dragovich PS, Eigenbrot C, Evangelista M, et al.

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(R)-GNE-140 from MedChemExpress

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(R)-GNE-140 from MedChemExpress

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