Reparixin from MedChemExpress

Product Specs
ItemReparixin
CompanyMedChemExpress
Price $140.00Supplier Page View Company Product Page
Catalog NumberHY-15251
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.99%
FormulaC14H21NO3S
Research AreaInflammation/Immunology; Endocrinology; Cancer
TypeChemical
Molecular Weight283.39
Quantity10 mM * 1 mL
Molecule NameReparixin

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(1) Respiratory viral infections prime accelerated lung cancer growthCellMarch 11, 2026Wei Qian, Xiaoqin Wei, Andrew J. Barros, Xiangyu Ye, Haibo Zhang, Qing Yu, Samuel P. Young, Eric V. Yeatts, Yury Park, Chaofan Li, et al.22-110-869 Triton X-100,Fisher Scientific,Cat# M1122980101 CXCR2 inhibitor Reparixin,MedChemExpress,Cat# HY-15251 Propiolactone,MedChemExpress,Cat# HY-107931 LPS from E. coli O55:B5,InvivoGen,Cat# tlrl-b5lps AddaVax,InvivoGen,Cat#

(2) Extracellular vesicles derived from pro-inflammatory M1 macrophages induce an inflammatory and invasive phenotype in melanoma cellsCell Communication and SignalingDecember 3, 2025Kaisa Mäki-Mantila, Einari A. Niskanen, Kirsi Kainulainen, Laia Puig Pardas, Niina Aaltonen, Wafa Wahbi, Piia Takabe, Aino Rönkä, Kirsi Rilla, Sanna Pasonen-SeppänenMedchemExpress), TNFR antagonist R-7050 (2 µM, HY-110203, MedchemExpress), CXCR1/2 inhibitor Reparixin (5 µM, HY-15251, MedchemExpress) and CXCR3 antagonist NBI-74330 (10 µM, HY-15320 MedchemExpress) or with equal amounts

(3) Mast cells interact directly with colorectal cancer cells to promote epithelial-to-mesenchymal transitionOncogeneNovember 1, 2025Lanzloth R, Harris NL, Cannon AM, Kaplan MH, O'Hagan HM.cells were starved overnight in media lacking SCF or FBS, respectively. Reparixin (MedChemExpress, HY-15251), Calcium Ionophore (Sigma-Aldrich, C7522), BAPTA-AM (MedChemExpress, HY-100545), LY294002 (MedChemExpress,

(4) Respiratory viral infections prime accelerated lung cancer growthbioRxivSeptember 11, 2025Wei Qian, Xiaoqin Wei, Andrew J Barros, Xiangyu Ye, Qing Yu, Samuel P Young, Eric V Yeatts, Yury Park, Chaofan Li, Gislane Almeida-Santos, et al.22-110-869 Triton X-100,Fisher Scientific,Cat# M1122980101 CXCR2 inhibitor Reparixin,MedChemExpress,Cat# HY-15251 LPS from E. coli O55:B5,InvivoGen,Cat# tlrl-b5lps "Collagenase, Type 2",Worthington Biochemical Corporation,Cat#

(5) Single‐Cell Transcriptome Profiling Reveals Conserved IFNγ‐IL8 Signaling‐Induced Antibacterial Neutrophil States during Bacterial InfectionAdvanced ScienceJuly 1, 2025Xue Zhai, Minghao Zhang, Kang Li, Wei Li, Xiaolong Li, Wa Gao, Zhaosheng Sun, Dan Huang, Songqian Huang, Mingli Liu, et al.first treated with 100 µm CXCR1/2 inhibitor reparixin (IL8 pathway blocker)[ 41 ] (MedChemExpress, HY‐15251) at 37 °C for 24 h. For STAT1 inhibitor assay, dHL‐60 cells were first stimulated with 200 ng ml−1 IFNγ

(6) Single‐Cell Landscape of Bronchoalveolar Lavage Fluid Identifies Specific Neutrophils during Septic ImmunosuppressionAdvanced ScienceJanuary 30, 2025Rong Shen, Yi Jiang, Guanglong Liu, Shenjia Gao, Hao Sun, Xinyi Wu, Jiahui Gu, Han Wu, Ke Mo, Xing Niu, et al.(10–100 ng mL−1, MedChemExpress, HY‐P70508) for 1 h.[ 77 , 78 ] Reparixin (1 mm, MedChemExpress, HY‐15251) was used for IL‐8 and CXCL1 inhibition. Neutrophil‐CD4+ T Cell Co‐Culture CD4+ T cells were isolated

(7) Fusobacterium nucleatum promotes colorectal cancer liver metastasis via miR-5692a/IL-8 axis by inducing epithelial-mesenchymal transitionJ Biomed SciJanuary 6, 2025Yulong Yu, Han Yin, Bili Wu, Weiheng Zhao, Yuan Wang, Aifeina Aili, Mu Yang, Qianqian Yu, Xianglin Yuandissolved in PBS with 0.1%BSA at a concentration of 100ng/ml. Reparixin (an inhibitor of CXCR1/2, MCE, HY-15251), MK2206(an inhibitor of AKT, MCE, HY-10358), U0126(an inhibitor of ERK, MCE, HY-12031), SB203580(an

(8) Chemokine expression profile of an innate granulomaeLifeNovember 14, 2024Amason ME, Beatty CJ, Harvest CK, Saban DR, Miao EA.MA)",Ref# 88-7391-22, "Chemical compound, drug",Reparixin,"MedChemExpress (Monmouth Junction, NJ)",Ref# HY-15251, "Software, algorithm",RStudio,"Posit PBC (Boston, MA)",, "Software, algorithm",FlowJo,BD Biosciences,, "Software,

(9) Novel Function of Cancer Stem Cell Marker ALDH1A3 in Glioblastoma: Pro-Angiogenesis through Paracrine PAI-1 and IL-8CancersSeptember 4, 2023Chen Z, Will R, Kim SN, Busch MA, Dünker N, Dammann P, Sure U, Zhu Y.MedChemExpress, Monmouth Junction, NJ, USA), a small-molecule inhibitor of PAI-1, and reparixin (cat# HY-15251; Med-ChemExpress), an allosteric inhibitor of the IL-8 receptors CXCR1 and CXCR2. Both inhibitors were

(10) CXCR1 and its downstream NF-ÎºB inflammation signaling pathway as a key target of Guanxinning injection for myocardial ischemia/reperfusion injuryFrontiers in ImmunologyOctober 17, 2022Guangxu Xiao, Jiaxu Liu, Huanyi Wang, Shuang He, Jianwei Liu, Guanwei Fan, Ming Lyu, Yan ZhuAminotransferase Assay Kit (GM0240) were purchased from WANTAI DRD Co., Ltd (Beijing, China). Reparixin (HY-15251) was purchased from MedChemExpress (New Jersey, United States). Experimental animals All animal experiment

(11) CXCL8 Associated Dendritic Cell Activation Marker Expression and Recruitment as Indicators of Favorable Outcomes in Colorectal CancerFrontiers in immunologyJanuary 1, 2021Li E, Yang X, Du Y, Wang G, Chan DW, Wu D, Xu P, Ni P, Xu D, Hu Y.mouse on day 0, and the treatment started on the same day after injection of tumor cells. Reparixin (HY-15251) and danirixin (HY-19768) were purchased from MedChem Express (MCE, NJ, USA) and dissolved in DMSO for

(12) Neuropilin-1 is up-regulated by cancer-associated fibroblast-secreted IL-8 and associated with cell proliferation of gallbladder cancerJournal of cellular and molecular medicineNovember 1, 2020Chen C, Zhang R, Ma L, Li Q, Zhao YL, Zhang GJ, Zhang D, Li WZ, Cao S, Wang L, et al.secondary antibody to Mouse IgG‐H&L (Goat polyclonal, ab150113, Abcam), IL‐8 receptors inhibitor Reparixin (HY‐15251, MCE) and Human IL‐8 ELISA Kit (KE00006, Proteintech Group). 2.4 Determination of cytokines secreted

(13) Human Naive T Cells Express Functional CXCL8 and Promote TumorigenesisJournal of immunology (Baltimore, Md. : 1950)July 15, 2018Crespo J, Wu K, Li W, Kryczek I, Maj T, Vatan L, Wei S, Opipari AW, Zou W.

(14) Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone lossAnnals of the rheumatic diseasesApril 1, 2016Krishnamurthy A, Joshua V, Haj Hensvold A, Jin T, Sun M, Vivar N, Ytterberg AJ, Engström M, Fernandes-Cerqueira C, Amara K, et al.

(15) Blockade of CXCR1/2 chemokine receptors protects against brain damage in ischemic stroke in miceClinics (Sao Paulo, Brazil)January 1, 2013Sousa LF, Coelho FM, Rodrigues DH, Campos AC, Barcelos Lda S, Teixeira MM, Rachid MA, Teixeira AL.

(16) Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR2 non-competitive allosteric inhibitorBritish journal of pharmacologyJanuary 1, 2012Bertini R, Barcelos LS, Beccari AR, Cavalieri B, Moriconi A, Bizzarri C, Di Benedetto P, Di Giacinto C, Gloaguen I, Galliera E, et al.

(17) Reparixin, an inhibitor of CXCR1 and CXCR2 receptor activation, attenuates blood pressure and hypertension-related mediators expression in spontaneously hypertensive ratsBiological & pharmaceutical bulletinJanuary 1, 2011Kim HY, Choi JH, Kang YJ, Park SY, Choi HC, Kim HS.

(18) Design of noncompetitive interleukin-8 inhibitors acting on CXCR1 and CXCR2Journal of medicinal chemistryAugust 23, 2007Moriconi A, Cesta MC, Cervellera MN, Aramini A, Coniglio S, Colagioia S, Beccari AR, Bizzarri C, Cavicchia MR, Locati M, et al.

(19) Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injuryProceedings of the National Academy of Sciences of the United States of AmericaAugust 10, 2004Bertini R, Allegretti M, Bizzarri C, Moriconi A, Locati M, Zampella G, Cervellera MN, Di Cioccio V, Cesta MC, Galliera E, et al.

(20) Clostridium difficile colitis requiring subtotal colectomy in a renal transplant recipient: a case report and review of literatureTransplantation proceedingsNovember 1, 1998Mistry B, Longo W, Solomon H, Garvin P.

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Reparixin from MedChemExpress

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Reparixin from MedChemExpress

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