HA15 from MedChemExpress

Product Specs
ItemHA15
CompanyMedChemExpress
Price $84.00Supplier Page View Company Product Page
Catalog NumberHY-100437
Molecule NameHA15
Quantity10 mM * 1 mL
Molecular Weight466.58
TypeChemical
Research AreaCancer
FormulaC23H22N4O3S2
Purity99.98%
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting

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(1) Multi-omics-informed hydrogel design: modulating IL-6 to reduce endoplasmic reticulum stress in bone regenerationBioact MaterOctober 15, 2025Jiannan Zhou, Jingtao Dai, Shixian Hu, Cancan Qi, Jiahao Chen, Wentai Zhang, Dorothea Alexander, An Li, Yin Xiao, Ping Limade at the medial epicondyle of the femur in nine rats. Following the femoral defect creation, HA15 (HY-100437, MCE, US), LMT28 (HY-102084, MCE, US), HM03 (HY-125974, MCE, US), and SC144 (HY-15614, MCE, US) were

(2) Bacteroides uniformis ameliorates pro-inflammatory diet-exacerbated colitis by targeting endoplasmic reticulum stress-mediated ferroptosisJournal of Advanced ResearchOctober 1, 2025Caiguang Liu, Linxin Liu, Zhenyi Tian, Shukai Zhan, Yun Qiu, Manying Li, Tong Li, Ren Mao, Shenghong Zhang, Minhu Chen, et al.105 cells/well. Upon reaching 70–80 % confluence, the cell were treated with HSPA5 inhibitor (1 uM, HY-100437, MCE, Shanghai, China), HSPA5 recombined protein (10 ng / mL, HY-P71742, MCE, Shanghai, China) or PERK

(3) GSDME Deficiency Suppresses ER Stress-Induced Autophagic Cell Death via mTOR/S6K1 Activation in Hepatobiliary CarcinomasBiochemical GeneticsMay 23, 2025Lei Sun, Gaoyan Tang, Mingyan Zhang, Hao Zhou, Yanan Liu, Xuelei Cao, Jian ZhangMethods Chemicals and Reagent YUM70 (Cat# S6193) was purchased from Selleck (Houston, TX, USA), and HA15 (Cat# HY-100437) from MedChemExpress (Monmouth Junction, NJ, USA). Both GRP78 inhibitors were dissolved in DMSO to a

(4) SIRT7 orchestrates melanoma progression by simultaneously promoting cell survival and immune evasion via UPR activationSignal transduction and targeted therapyMarch 15, 2023Yi X, Wang H, Yang Y, Wang H, Zhang H, Guo S, Chen J, Du J, Tian Y, Ma J, et al.Pyrrolidinedithiocarbamate ammonium (APDC, HY-18738), human PD-L1 neutralizing antibody (Avelumab, HY-108730) and HA15 (HY-100437) were purchased from MedChemExpress (Monmouth Junction, NJ, USA). Cell culture and stable transfection Human

(5) Targeting GRP78 suppresses oncogenic KRAS protein expression and reduces viability of cancer cells bearing various KRAS mutationsNeoplasia (New York, N.Y.)November 1, 2022Ha DP, Huang B, Wang H, Rangel DF, Van Krieken R, Liu Z, Samanta S, Neamati N, Lee AS.been previously described [29]. HA15 was purchased from MedChemExpress LLC (Monmouth Junction, NJ, Cat#HY-100437). 3-Methyladenine (3-MA) and Chloroquine was purchased from Millipore Sigma (Burlington, MA, Cat#M9281

(6) Proteomic Discovery of VEEV E2-Host Partner Interactions Identifies GRP78 Inhibitor HA15 as a Potential Therapeutic for Alphavirus InfectionsPathogensMarch 2, 2021Michael D. Barrera, Victoria Callahan, Ivan Akhrymuk, Nishank Bhalla, Weidong Zhou, Catherine Campbell, Aarthi Narayanan, Kylene Kehn-Halldescribed. Fresh medium containing inhibitor (or solvent control) was reapplied. HA15 (MedChemExpress, HY-100437, Monmouth Junction, NJ, USA), VER-155008 (MedChemExpress, HY-10941, Monmouth Junction, NJ, USA), BTB06584

(7) Ubiquitin C-terminal hydrolase L1 (UCHL1) regulates post-myocardial infarction cardiac fibrosis through glucose-regulated protein of 78 kDa (GRP78)Scientific reportsJune 30, 2020Lei Q, Yi T, Li H, Yan Z, Lv Z, Li G, Wang Y.MedChemExpress) was added for 6 h before the completion of the TGF-β1 stimulation. The GRP78 inhibitor HA15 (HY-100437, MedChemExpress), at a final concentration of 10 μM, was treated for 24 h at the beginning of TGF-β1

(8) Endoplasmic Reticulum Stress Signaling as a Therapeutic Target in Malignant Pleural MesotheliomaCancersOctober 8, 2019Xu D, Yang H, Yang Z, Berezowska S, Gao Y, Liang SQ, Marti TM, Hall SRR, Dorn P, Kocher GJ, et al.

(9) The GRP78/BiP inhibitor HA15 synergizes with mitotane action against adrenocortical carcinoma cells through convergent activation of ER stress pathwaysMolecular and cellular endocrinologyOctober 15, 2018Ruggiero C, Doghman-Bouguerra M, Ronco C, Benhida R, Rocchi S, Lalli E.

(10) Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor ResistanceCancer cellJune 13, 2016Cerezo M, Lehraiki A, Millet A, Rouaud F, Plaisant M, Jaune E, Botton T, Ronco C, Abbe P, Amdouni H, et al.

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