(R)-Roscovitine from MedChemExpress

Product Specs
Item(R)-Roscovitine
CompanyMedChemExpress
Price $87.00Supplier Page View Company Product Page
Catalog NumberHY-30237
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.53%
TypeChemical
Molecular Weight354.45
FormulaC₁₉H₂₆N₆O
Research AreaCancer

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(1) DNA replication stress and translational repression converge to drive CDK1- and caspase-dependent apoptosis in Ewing sarcomaOncogeneJune 10, 2026Stacia L. Koppenhafer, Mary V. Thomas, Mian T. Mhindu, Jessica A. O. Zimmerman, David J. GordonRP-6306 (HY-145817A), staurosporine (HY-15141), RO-3306 (HY-12529), AZD5438 (HY-10012), roscovitine (HY-30237), Z-VAD-FMK (HY-16658B), Q-VD-OPh (HY-12305), emricasan (HY-10396) were obtained from MedChemExpress.

(2) Apical size reduction by macropinocytosis alleviates tissue crowdingNat CommunJune 23, 2025Enzo Bresteau, Eve E. Suva, Christopher Revell, Osama A. Hassan, Aline Grata, Jennifer Sheridan, Jennifer Mitchell, Constadina Arvanitis, Farida Korobova, Sarah Woolner, et al.MCC extrusion, embryos were treated for 24 h from stage 44/45 with either DMSO or 50 μM Roscovitine (#HY-30237, MedChemExpress) in 0.1× MMR. Subsequently, embryos were either imaged for 30 min to measure macropinocytosis

(3) Functional optic tract rewiring via subtype- and target-specific axonal regeneration and presynaptic activity enhancementNat CommunMarch 4, 2025Xin Zhang, Chao Yang, Chengle Zhang, Junqiang Wu, Xiang Zhang, Jiayang Gao, Xuejie Wang, Leung Ting Chan, Yiren Zhou, Yujun Chen, et al.before light stimulation. For the mice that underwent the PLR test after R-roscovitine (MedChemExpress, HY-30237) and S-roscovitine (AdipoGen, AG-MR-C0002-M025) administration, they were dark-adapted for 2 h before

(4) E2F1/CDK5/DRP1 axis mediates microglial mitochondrial division and autophagy in the pathogenesis of cerebral ischemia-reperfusion injuryClin Transl MedFebruary 19, 2025Ya-Jing Yuan, Tingting Chen, Yan-Ling Yang, Hao-Nan Han, Li-Ming Xu(10 mmol/L). The treatment involved using 15 µmol of the CDK5 inhibitor Roscovitine (product code: HY‐30237, MCE), 10 µmol of the dynamin‐related protein 1 (DRP1) inhibitor Mdivi‐1 (Product Code: HY‐15886, MCE),

(5) Astrocyte-induced Cdk5 expedites breast cancer brain metastasis by suppressing MHC-I expression to evade immune recognitionNature Cell BiologyOctober 1, 2024Arseniy E. Yuzhalin, Frank J. Lowery, Yohei Saito, Xiangliang Yuan, Jun Yao, Yimin Duan, Jingzhen Ding, Sunil Acharya, Chenyu Zhang, Abigail Fajardo, et al.on days 6, 9 and 12 following ICA injection. For in vivo administration of RSV, we used 99.94% RSV (HY-30237, MedChemExpress). RSV was diluted in dimethyl sulfoxide (DMSO) to a concentration of 100 mg ml−1. The

(6) CDK9 inhibition by dinaciclib is a therapeutic vulnerability in epithelioid hemangioendotheliomaClin Cancer ResSeptember 13, 2024Ajaybabu V. Pobbati, Ashley Burtscher, Nandini Rajaram Siva, Andrea Hallett, Todd Romigh, Kepeng Che, Bin Zhao, Jesse A. Coker, Nancy Wang, Shaun R. Stauffer, et al.palbociclib (Cat # HY-50767), RO-3306 (Cat # HY-12529), CVT-313 (Cat # HY-15339), roscovitine (Cat # HY-30237), AZD4573 (Cat # HY-112088) used in this study were purchased from MedChemExpress. MG-132 (Cat # 2194)

(7) CDK9 Inhibition by Dinaciclib Is a Therapeutic Vulnerability in Epithelioid HemangioendotheliomaClinical Cancer ResearchSeptember 13, 2024Ajaybabu V. Pobbati, Ashley Burtscher, Nandini Rajaram Rajaram Siva, Andrea Hallett, Todd Romigh, Kepeng Che, Bin Zhao, Jesse A. Coker, Nancy Wang, Shaun R. Stauffer, et al.palbociclib (Cat # HY-50767), RO-3306 (Cat # HY-12529), CVT-313 (Cat # HY-15339), roscovitine (Cat # HY-30237), AZD4573 (Cat # HY-112088) used in this study were purchased from MedChemExpress. MG-132 (Cat # 2194)

(8) Neuronal double-stranded DNA accumulation induced by DNase II deficiency drives tau phosphorylation and neurodegenerationTranslational neurodegenerationAugust 2, 2024Li LJ, Sun XY, Huang YR, Lu S, Xu YM, Yang J, Xie XX, Zhu J, Niu XY, Wang D, et al.Meanwhile, at 48 h after infection, the cells were treated with 2.5 μM roscovitine [28] (MedChemExpress, #HY-30237) for 24 h to inhibit CDK5, or 5 μM DT061 [29] (MedChemExpress, #HY-112929) for 24 h to activate PP2A.

(9) Phosphorylated SHMT2 Regulates Oncogenesis Through m6A Modification in Lung AdenocarcinomaAdvanced ScienceMay 1, 2024Tianyu Han, Yanan Wang, Minzhang Cheng, Qifan Hu, Xiaorui Wan, Menglin Huang, Yuhan Liu, Wenze Xun, Jin Xu, Lei Wang, et al.(HY‐L0001). The kinase inhibitors BDP5290 (HY‐12437), LY3214996 (HY‐101494), PIM447 (HY‐19322), seliciclib (HY‐30237), tomivosertib (HY‐100022), and DMAT (HY‐15535) were purchased from MCE. H2DCFDA (DCFH‐DA) was purchased

(10) Selective PPARγ modulator diosmin improves insulin sensitivity and promotes browning of white fatThe Journal of biological chemistryApril 1, 2023Yu J, Hu Y, Sheng M, Gao M, Guo W, Zhang Z, Wang D, Wu X, Li J, Chen Y, et al.for the whole differentiation process. GW9662 and roscovitine were purchased from MCE (catalog nos.: HY-30237 and HY-16578). Lipid accumulation in beige adipocytes treated with rosiglitazone or diosmin was detected

(11) PTEN loss promotes Warburg effect and prostate cancer cell growth by inducing FBP1 degradationFrontiers in OncologySeptember 27, 2022Changze Song, Jianong Zhang, Xiao Liu, Meilu Li, Dejie Wang, Zhijian Kang, Jiaao Yu, Jiuwei Chen, Hongxin Pan, Honglei Wang, et al.well in 6-well plates. The next day, the cells were treated with vehicle or Roscovitine (10 μM, Cat# HY-30237, MedChemExpress). After about 16 days of treatment, the cells were fixed with 4% paraformaldehyde for

(12) Live cell, image-based high-throughput screen to quantitate p53 stabilization and viability in human papillomavirus positive cancer cellsVirologyAugust 1, 2021Martínez-Noël G, Vieira VC, Szajner P, Lilienthal EM, Kramer RE, Boyland KA, Smith JA, Howley PM.actinomycin D (Sigma, A1410); Velcade (EMD Millipore Corp, 5.04314.0001); roscovitine (MedChemExpress, HY-30237); RITA (MedChemExpress, HY-13424); curcumin (MedChemExpress, HY-N0005), and ellagic acid (MedChemExpress,

(13) Genetically Defined, Syngeneic Organoid Platform for Developing Combination Therapies for Ovarian CancerCancer discoveryFebruary 1, 2021Zhang S, Iyer S, Ran H, Dolgalev I, Gu S, Wei W, Foster CJR, Loomis CA, Olvera N, Dao F, et al.Doxorubin (sigma, D1515), Paclitaxel (Selleckchem, S1150), Carboplatin (Sigma, 1096407), Seliciclib (MCE, HY-30237), PHA767491(Sigma, PZ0178), BAY1895344 (Selleckchem, S8666), Chloroquine (Selleckchem, S4157) and YKL-5–124

(14) Selective antitumor activity of roscovitine in head and neck cancerOncotargetJune 21, 2016Gary C, Hajek M, Biktasova A, Bellinger G, Yarbrough WG, Issaeva N.

(15) CDK5 promotes renal tubulointerstitial fibrosis in diabetic nephropathy via ERK1/2/PPARγ pathwayOncotargetJune 14, 2016Bai X, Hou X, Tian J, Geng J, Li X.

(16) Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5European journal of biochemistryJanuary 15, 1997Meijer L, Borgne A, Mulner O, Chong JP, Blow JJ, Inagaki N, Inagaki M, Delcros JG, Moulinoux JP.

(17) [Effect of the dose of ptsI- and ptsH-genes on carbohydrate transport and regulation of lac-operon activity in Escherichia coli K-12]GenetikaJanuary 1, 1979Gershanovich VN, Umiarov AM, Il'ina TS, Burd GI, Bol'shakova TN.

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(R)-Roscovitine from MedChemExpress

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(R)-Roscovitine from MedChemExpress

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