Ravoxertinib from MedChemExpress

Product Specs
ItemRavoxertinib
CompanyMedChemExpress
Price $106.00Supplier Page View Company Product Page
Catalog NumberHY-15947
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.84%
TypeChemical
Molecular Weight440.86
FormulaC₂₁H₁₈ClFN₆O₂
Research AreaCancer

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(1) Bifendate inhibits cell PARthanatos by activating the MEK/ERK pathwayBiochemistry and Biophysics ReportsMarch 1, 2026Ao-meng Hu, Meng Chen, Can-can Zhu, Zai-man Zhu, Xiao-hui XuNecrostatin-1, MCE, #HY-15760; Olaparib, MCE, #HY-10162; 3 MA, MCE, #HY-19312; Ravoxertinib, MCE, #HY-15947; Bifendate, ZZBIO, #ZC-65994; Bicyclol, TargetMol, #T4121; Schisandrin A, MCE, # HY-N0693; Schisandrin B

(2) ASCT2 palmitoylation regulated by JNK1-ZDHHC14 axis orchestrates glutamine metabolism and NSCLC progressionCell DiscoveryFebruary 24, 2026Xingyu Chen, Zihao Ke, Shihui Wei, Jiajin Chen, Ke Zhu, Jiaqi Xu, Yun Zhao, Mengyuan Cen, Yan Jin, Zhilei Pan, et al.(#HY-10455), V9302 (#HY-112683 & #HY-112683A), LY294002 (#HY-10108), AZD5363 (#HY-15431), Ravoxertinib (#HY-15947), SCH772984 (#HY-50846), Adezmapimod (#HY-10256), SB-202190 (#HY-10295), Dorsomorphin dihydrochloride

(3) Inhibition of GRK2-PDE4D Axis Suppresses Fibroblast-Like Synoviocytes Hyperplasia and Alleviates Experimental ArthritisInternational Journal of Biological SciencesJanuary 27, 2025Dafei Han, Hanfei Sun, Renhao Zhang, Hui Ge, Paipai Guo, Rui Chu, Ruhong Fang, Yongsheng Han, Shufang He, Rui Li, et al.HY-14761), a p38 inhibitor (Doramapimod, 10 μM, HY-10320), and an ERK inhibitor (Ravoxertinib, 5 μM, HY-15947), all obtained from MedChemExpress (NJ, USA). CP-25 (1 μM) was used as a positive control to inhibit

(4) Clinical functional proteomics of intercellular signalling in pancreatic cancerNatureJanuary 16, 2025Peiwu Huang, Weina Gao, Changying Fu, Min Wang, Yunguang Li, Bizhu Chu, An He, Yuan Li, Xiaomei Deng, Yehan Zhang, et al.MedChemExpress, HY-50856), MEKs (mirdametinib, MedChemExpress, HY-10254), ERKs (ravoxertinib, MedChemExpress, HY-15947), or PI3K (LY294002, MedChemExpress, HY-10108), respectively, before CM was collected. The Simoa ELISA

(5) AIBP protects drug-induced liver injury by inhibiting MAPK-mediated NR4A1 expressioniScienceOctober 18, 2024Tao Ma, Wei Huang, Yihong Ding, Ran Ji, Sijia Ge, Qingqing Liu, Yiheng Liu, Jing Chen, Yang Yan, Shushu Lu, et al.recombinant proteins","Chemicals, peptides, and recombinant proteins" ,, GDC 0994,MedChemExpress,HY-15947 SB 203580,MedChemExpress,HY-10256 SP 600125,MedChemExpress,HY-12041 APAP,Sangon Biotech,A506808 ,, Experimental models

(6) IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxiaNature CommunicationsSeptember 30, 2023Ke Zheng, Nannan Sha, Guofang Hou, Zhuyun Leng, Qin Zhao, Li Zhang, Lingnan He, Meidong Xu, Yuhui Jiang, Tao Chenfor IHC, 1:50 for IF) antibody was made by Signalway Antibody. Materials PPP (HY-15494), GDC-0994 (HY-15947), and ARQ-092 (HY-19719) were purchased from MedChemExpress. Proline (P0380), NAD+ (N3014), and NADH

(7) EP1 activation inhibits doxorubicin-cardiomyocyte ferroptosis via Nrf2Redox BiologySeptember 1, 2023Bei Wang, Yuxuan Jin, Jiao Liu, Qian Liu, Yujun Shen, Shengkai Zuo, Ying YuSelleck Chemicals (Houston, TX, USA). Wortmannin (#HY-10197), SP600125 (#HY-12041), and Ravoxertinib (#HY-15947) were purchased from MedChemExpress (MCE) Company (Shanghai, China). 2.2 Experimental animals Eight-to

(8) Regulatory roles of Osteopontin in lung epithelial inflammation and epithelial-telocyte interactionClin Transl MedAugust 21, 2023Huirong Fu, Xuanqi Liu, Lin Shi, Lingyan Wang, Hao Fang, Xiangdong Wang, Dongli Songplate and at the upper chamber (140620; ThermoFisher), respectively. LY294002 (HY‐10108) and GDC‐0994 (HY‐15947) were obtained from MedChemExpress. Transfection reagents Lipofectamine 2000 (11668019) and Lipofectamine 3000

(9) Overexpression of mitogen-activated protein kinase phosphatase-1 in endothelial cells reduces blood-brain barrier injury in a mouse model of ischemic strokeNeural regeneration researchAugust 1, 2023Qin XD, Yang TQ, Zeng JH, Cai HB, Qi SH, Jiang JJ, Cheng Y, Xu LS, Bu F.HY-115502) or 10 nM of the ERK1/2 inhibitor (Blake et al., 2016) ravoxertinib (MedChemExpress, Cat# HY-15947) during and after OGD. The chemicals were dissolved in 0.1% dimethyl sulfoxide. An equal amount of dimethyl

(10) FOLFOXIRI Resistance Induction and Characterization in Human Colorectal Cancer CellsCancersSeptember 30, 2022Ramzy GM, Boschung L, Koessler T, Delucinge-Vivier C, Docquier M, McKee TA, Rubbia-Brandt L, Nowak-Sliwinska P.respectively, to a concentration of 20 mg/mL, 15 mg/mL, 20 mg/mL; Selumetinib (HY-50706) and GDC-0994 (HY-15947), SN38 (29112) were obtained from MedChemExpress (Monmouth Junction, NJ, USA) and diluted, respectively,

(11) Jujuboside A Exhibits an Antiepileptogenic Effect in the Rat Model via Protection against Traumatic Epilepsy-Induced Oxidative Stress and Inflammatory ResponsesEvidence-Based Complementary and Alternative MedicineSeptember 9, 2022Wei Lu, Zhangze Wu, Chong Zhang, Tingting Gao, Xiaoyang Ling, Min Xu, Wenhua Wang, Xuegang Jin, Keran Li, Long Chen, et al.specific inhibitor) (cat. No. HY-10256) and ravoxertinib (ERK pathway specific inhibitor) (cat. No. HY-15947) (MedChemExpress, China); anti-p-P38 (cat. No. ab4822) (1 : 1,000 dilution), anti-p-ERK1/2 (cat. No.

(12) Production of functional sperm from in vitro-cultured premeiotic spermatogonia in a marine fishZoological ResearchJuly 18, 2022Hong Zhang et al.(HY-101176, MCE, USA) (3D+Hor+2-Iod), and 1 µmol/L melatonin and 1 µmol/L ERK inhibitor ravoxertinib (HY-15947, MCE, USA) (3D+Hor+Mel+RX), respectively. The cells were collected for analysis of germ cell proliferation

(13) Targeting SYK of monocyte-derived macrophages regulates liver fibrosis via crosstalking with Erk/Hif1α and remodeling liver inflammatory environmentCell death & diseaseDecember 1, 2021Chen X, Wang Z, Han S, Wang Z, Zhang Y, Li X, Xia N, Yu W, Jia C, Ni Y, et al.in vitro caused a decrease in the expression of p-SYK,p-Erk and HIF1α (Fig. 4F). Ravoxertinib (MCE, HY-15947) is an inhibitor of Erk kinase, which can effectively inhibit the phosphorylation of Erk1/2. We found

(14) SOX9 is a critical regulator of TSPAN8-mediated metastasis in pancreatic cancerOncogeneJuly 1, 2021Li J, Chen X, Zhu L, Lao Z, Zhou T, Zang L, Ge W, Jiang M, Xu J, Cao Y, et al.USA). Gefitinib (HY-50895), Erlotinib (HY-50896), AG1478 (HY-13524), Compound 26 (HY-18296), GDC-0994 (HY-15947) and GO6983 (HY-13689) were purchased from MedChemExpress (MCE) Company (Shanghai, China). Transfection Cells

(15) Optimized low-dose combinatorial drug treatment boosts selectivity and efficacy of colorectal carcinoma treatmentMolecular oncologyNovember 1, 2020Zoetemelk M, Ramzy GM, Rausch M, Koessler T, van Beijnum JR, Weiss A, Mieville V, Piersma SR, de Haas RR, Delucinge-Vivier C, et al.(Woburn, MA, USA); 20 mg/mL selumetinib (HY‐50706), 10 mg/mL AZD‐4547 (HY‐13330, 10 mg/mL GDC‐0994 (HY‐15947), 20 mg/mL folinic acid (HY‐17556), and 5 mg/mL oxaliplatin (HY‐17371) from MedChemExpress (Monmouth

(16) CXXC finger protein 4 inhibits the CDK18-ERK1/2 axis to suppress the immune escape of gastric cancer cells with involvement of ELK1/MIR100HG pathwayJournal of cellular and molecular medicineSeptember 1, 2020Li P, Ge D, Li P, Hu F, Chu J, Chen X, Song W, Wang A, Tian G, Gu X.Shanghai Genechem Co., Ltd., as well as ERK1/2 pathway inhibitor GDC‐0994 from MedChemExpress (10 µmol/L, HY‐15947), were used for cell transfection. After 6 hours, the culture medium was renewed and the cells were

(17) Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical DevelopmentJournal of medicinal chemistryJune 23, 2016Blake JF, Burkard M, Chan J, Chen H, Chou KJ, Diaz D, Dudley DA, Gaudino JJ, Gould SE, Grina J, et al.

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Ravoxertinib from MedChemExpress

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Ravoxertinib from MedChemExpress

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