Subasumstat from MedChemExpress

Product Specs
ItemSubasumstat
CompanyMedChemExpress
Price $254.00Supplier Page View Company Product Page
Catalog NumberHY-111789
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity98.53%
TypeChemical
Molecular Weight578.10
FormulaC25H28ClN5O5S2
Research AreaInflammation/Immunology; Cancer
Molecule NameSubasumstat

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(1) A short SUMOylation tag modulates transcription factor activityThe Journal of biological chemistryNovember 1, 2025Bouchard AY, Vivet AJI, Cabana VC, Li C, Thibault P, Lussier MP, Mader S, Cappadocia L.[(1R,2S,4R)-4-[[5-[4-[(1R)-7-chloro-1,2,3,4-tetrahydroisoquinolin-1-yl]-5-methylthiophene-2-carbonyl]pyrimidin-4-yl]amino]-2-hydroxycyclopentyl]methyl sulfamate (TAK981) was from MedChemexpress (Cat. No. HY-111789). Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal (MG132) was from Ubiquitin-Proteasome Biotechnologies LLC

(2) Targeting SUMO2 reverses aberrant epigenetic rewiring driven by SS18::SSX fusion oncoproteins and impairs sarcomagenesisThe EMBO JournalAugust 13, 2025Rema Iyer, Anagha Deshpande, Aditi Pedgaonkar, Pramod Akula Bala, Taehee Kim, Gerard L Brien, Darren Finlay, Kristiina Vuori, Alice Soragni, Hiromi I Wetterstein, et al.days before initiating drug treatment. Pre-warmed Mammocult medium containing TAK-981 (MedChemExpress #HY-111789) at six different concentrations diluted in DMSO (Fisher Scientific #BP231-100) was added to the plates

(3) Synthetic inhibition of the SUMO pathway by targeting the SAE1 component via TAK-981 compound impairs growth and chemosensitizes embryonal and alveolar rhabdomyosarcoma cell linesMolecular and Cellular BiochemistryJune 23, 2025Silvia Codenotti, Volker M. Lauschke, Emma V. Casella, Daniel C. Andersson, Alessandro Fanzani, Stefano GastaldelloDoxorubicin (5927S) was purchased from Cell Signaling Technologies (MA, USA). Subasumstat (TAK-981, HY111789) was purchased from MedChemExpress MCE (Stockholm, Sweden). Complete™ protease inhibitors cocktail tablets

(4) Nuclear SUMOylation and Proteotoxic Stress Responses to Metals with Different Ligand PreferencesChemical Research in ToxicologyMay 19, 2025Giorgiana Madalina Ursu, Casey Krawic, Anatoly Zhitkovichdehydro-L-(+)-ascorbic acid (D8132) and K2CrO4 (216615) were purchased from Sigma-Aldrich. TAK981 (HY-111789) was obtained from MedChemExpress. MG132 was from Selleckchem (S2619). Cell culture and metal treatments. H460

(5) Human ANP32A/B are SUMOylated and utilized by avian influenza virus NS2 protein to overcome species-specific restrictionNature communicationsDecember 30, 2024Sun L, Guo X, Yu M, Wang XF, Ren H, Wang X.The SUMOylation enzymatic cascade inhibitor subasumstat (TAK-981) was purchased from MedChemExpress (HY-111789). The reverse genetic system for A/chicken/Zhejiang/B2013/2012 (H9N2) and plasmids pCAGGS-PB1, pCAGGS-PB2,

(6) Intra-tumoral YAP and TAZ heterogeneity drives collective NSCLC invasion that is targeted by SUMOylation inhibitor TAK-981iScienceNovember 15, 2024Richa Sharma, Shagun Sharma, Pratik Shriwas, Labdhi Mehta, An H. Vu, Janna K. Mouw, Junghui Koo, Chunzi Huang, Veronika Y. Matsuk, Carol Tucker-Burden, et al.AKT inhibitor VIII,MedChemExpress,Cat#HY-10355 EGF recombinant protein,Thermo Scientific,Cat#AF-100-15 TAK-981,MedChemExpress,Cat#HY-111789 ,, Critical commercial assays,Critical commercial assays,Critical commercial assays ,, CellTiter-Glo

(7) Regulation of Enhancers by SUMOylation Through TFAP2C Binding and Recruitment of HDAC Complex to the ChromatinResearch SquareNovember 13, 2024Tharindumala Abeywardana, Xiwei Wu, Shih-Ting Huang, Grace Aldana Aldana Masangkay, Andrei S. Rodin, Sergio Branciamore, Grigoriy Gogoshin, Arthur Li, Li Du, Neranjan Tharuka, et al.according to the respective manufacturers’ protocols. TAK-981 was purchased from MedChemExpress (Cat. # HY-111789). Whole cell lysate was prepared by lysing the cell in 1X RIPA buffer (25 mM Tris pH 7–8, 150 mM NaCl,

(8) SUMO2 Inhibition Reverses Aberrant Epigenetic Rewiring Driven by Synovial Sarcoma Fusion Oncoproteins and Impairs SarcomagenesisbioRxivSeptember 30, 2024Rema Iyer, Anagha Deshpande, Aditi Pedgaonkar, Pramod Akula Bala, Taehee Kim, Gerard L. Brien, Darren Finlay, Kristiina Vuori, Alice Soragni, Rabi Murad, et al.days before initiating drug treatment. Pre-warmed Mammocult medium containing TAK-981 (MedChemExpress #HY-111789) at six different concentrations diluted in DMSO (Fisher Scientific #BP231-100) was added to the plates

(9) Transcription factor E2F4 facilitates SUMOylation to promote HCC progression through interaction with LIN9International Journal of OncologySeptember 2, 2024Zhenwei Ma, Qilan Li, Wenjing Wang, Zhengdong Dengand invasiveness of Huh7 cells, the SUMOylation inhibitor, TAK-981 (10 nM; MedChemExpress; cat. no. HY-111789), was added to the cell medium after E2F4-overexpression vector transfection. Following treatment, the

(10) PAX1 represses canonical Wnt signaling pathway and plays dual roles during endoderm differentiationCell Communication and SignalingApril 26, 2024Danxiu Miao, Jie Ren, Yanhan Jia, Yihui Jia, Yanshu Li, Huizhe Huang, Rui Gaocycloheximide (CHX) (MCE HY-12320) was used to inhibit protein synthesis. Subasumstat (TAK981; MCE HY-111789) was added to the medium with indicated concentration for 48 hours to inhibit SUMOylation. Luciferase

(11) SUMOylation indirectly suppresses activity of the HIF-1α pathway in intestinal epithelial cellsJournal of Biological ChemistryNovember 1, 2023Mykyta I. Malkov, Darragh Flood, Cormac T. TaylorThe SUMOylation enzymatic cascade inhibitor subasumstat (TAK-981) was obtained from MedChemExpress (HY-111789). The pan-hydroxylase inhibitor DMOG was purchased from Cayman Chemical (catalog no.: 71210). Reagent

(12) Glioblastoma upregulates SUMOylation of hnRNP A2/B1 to eliminate the tumor suppressor miR-204-3p, accelerating angiogenesis under hypoxiaCell death & diseaseFebruary 21, 2023Guo Q, Fan Y, Wang Q, Li B, Qiu W, Qi Y, Pan Z, Zhang S, Zhao S, Yang K, et al.XR (Apple, A2108) was used to take photographs at 7, 14, and 21 days after injection. TAK-981 (MCE, HY-111789) was diluted according to the instructions of MCE, and the experimental group was injected 25 mg/kg

(13) UBC9 deficiency enhances immunostimulatory macrophage activation and subsequent antitumor T cell response in prostate cancerThe Journal of clinical investigationFebruary 15, 2023Xiao J, Sun F, Wang YN, Liu B, Zhou P, Wang FX, Zhou HF, Ge Y, Yue TT, Luo JH, et al.MCE Biotechnology (Shanghai, China). The SUMOylation-activating enzyme E1 inhibitor TAK-981 (catalog HY-111789) and the proteasome inhibitor MG-132 (catalog HY-13259) were purchased from MCE Biotechnology, while

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Subasumstat from MedChemExpress

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Subasumstat from MedChemExpress

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