RGFP966 from MedChemExpress

Product Specs
ItemRGFP966
CompanyMedChemExpress
Price $99.00Supplier Page View Company Product Page
Catalog NumberHY-13909
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.81%
TypeChemical
Molecular Weight362.4
FormulaC₂₁H₁₉FN₄O
Research AreaCancer

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(1) Effects of Lysine Deacetylation Inhibition Alone or in Combination With Arimoclomol on TDP-43 ProteinopathyJ NeurochemJune 12, 2026Serena Scozzari, Stefano Fabrizio Columbro, Monica Favagrossa, Massimo Tortarolo, Alfredo Cagnotto, Mario Salmona, Giovanni De Marco, Caterina Bendotti, Andrea Calvo, Laura Pasetto, et al.MedChemExpress and were as follows: SAHA (cat. no. HY‐10221), RGFP109 (cat. no. HY‐16425), RGFP966 (cat. no. HY‐13909); ACY‐738 (cat. no. HY‐19327); tubastatin A (cat. no. HY‐13271A), selisistat (cat. no. HY‐15452), arimoclomol

(2) Methylation reader MBD2-mediated GPX4 transcriptional repression drives ovarian granulosa cell ferroptosis in PCOSRedox BiologyMarch 1, 2026Zhengquan Zhu, Yihan Wang, Xinye Yu, Tingyu Wang, Yin Li, Ruizhe Wang, Haiyun Chen, Binjia Ruan, Wangsen Cao, Gaojian Tao, et al.(50 μM, 48 h) treatment, followed by KCC-07 (10 μM, 48 h), 5-Aza (10 μM, 24 h), RGFP966 (10 μM, 48 h, HY-13909, MCE, USA), and/or Liproxstatin-1 (200 nM, 48 h, HY-12726, MCE, USA) treatments. A scrambled RNA of

(3) Preoperative exercise induces anti-tumor Kupffer cells to prevent surgical stress-promoted colorectal cancer liver metastasisCell Reports MedicineFebruary 17, 2026Yunwei Zhang, Yiyu Zhang, Chengli Shen, Jiye Li, Han Wang, Ahmad Hamad, Chunyan Cao, Mohamad El Moheb, Yu Wang, Yujia Xia, et al.HY-15319 Sodium Butyrate,Sigma-Aldrich,Cat# 567430 HDAC3 inhibitor (RGFP966),MedChemExpress,Cat# HY-13909 Firefly Luciferase (FLuc)-IRES-Puro Lentivirus,Biosettia,Cat# GlowCell-14p-10 D-Luciferin,Gold Biotechnology,Cat#

(4) LincRNA-p21: A Double-Edged Sword in Ethanol-Induced Liver Damage and Its Nanoparticle SolutionInt J NanomedicineFebruary 14, 2026Shun Wang, Zhao-Chao Nie, Yang Liu, Zhi-Yue Zhang, Yi-Min Feng, Chengwei Wang, Jun Jiang(SAHA)(#HY-10221, MCE, USA), sodium butyrate (NaB)(#S1999, Selleck, USA), and HDAC3 inhibitor RGFP966 (#HY-13909, MCE, USA) were used to study the mechanism of lincRNA-p21 regulation. HepG2 cells were treated with

(5) LincRNA-p21: A Double-Edged Sword in Ethanol-Induced Liver Damage and Its Nanoparticle SolutionInternational Journal of NanomedicineFebruary 14, 2026Shun Wang, Zhao-Chao Nie, Yang Liu, Zhi-Yue Zhang, Yi-Min Feng, Chengwei Wang, Jun Jiang(SAHA)(#HY-10221, MCE, USA), sodium butyrate (NaB)(#S1999, Selleck, USA), and HDAC3 inhibitor RGFP966 (#HY-13909, MCE, USA) were used to study the mechanism of lincRNA-p21 regulation. HepG2 cells were treated with

(6) Investigating the causal relationship of lipid metabolism in polycystic ovary syndrome: a Mendelian randomization study on the regulatory role of 3-Hydroxybutyrate in gene expressionFrontiers in MedicineFebruary 4, 2026Jia Xu, Lan Li, Shuo Yang, Ping Li, Bing He, Ji-lin Kuangglucose medium, 1% penicillin/streptomycin solution. HDAC3-specific inhibitor RGFP966 (MCE, Catalog No. HY-13909), 3-Hydroxybutyrate (MCE, Catalog No. HY-113378). Human Testosterone, T ELISA Kit (cusabio, Catalog

(7) DNTTIP1 drives leukaemogenesis through MiDAC‐mediated epigenetic silencing of BMFClinical and Translational MedicineFebruary 1, 2026Ruolin Xiu, Yuzhu Ma, Yueying Gao, Yao Chen, Xinyu Li, Yue Wu, Meiling Sun, Qizhao Li, Yanhong Zhao, Shuqian Xu, et al.(5‐AzaC) (MCE, HY‐10586), Olaparib (TargetMol, T3015), Merck60 (BRD‐6929) (MCE, HY‐100719), RGFP966 (MCE, HY‐13909) and FK228 (Romidepsin) (MCE, HY‐15149). Antibodies are summarised in Table S2. 2.4 Plasmid, lentivirus

(8) Epigenetic Suppression of RASAL1 by HDAC3 and Cofactor YY1 Promotes Fibroblast–Myofibroblast Transition and Renal FibrosisResearch (Wash D C)January 29, 2026Fang Chen, Lijun Zhang, Weiying Liu, Bingbing Zhang, Shuren Wang, Zhengdong Zhou, Wei Wang, Jiansong Shen, Yijun Deng, Wangsen Caostudy, C57BL/6 mice were randomly subjected to 4 groups: (a) sham/vehicle control, (b) RG treatment (HY-13909, MedChemExpress, USA; 10 mg/kg, subcutaneous injection starting the first day and following every other

(9) HDAC3 Mediates Hippocampal Microglial Pyroptosis Via the STING/NLRP3 Pathway and Contributes To Cognitive Impairment in Sepsis-Associated EncephalopathyInflammationJanuary 10, 2026Meng Cai, Hua Shao, Shan Xu, He Wang, Meng-jie Yang, Tong Zhu, Jiang Chen, Gui-zhou Li, Shuai-fei Lu, Yan-yu Zang, et al.vehicle, sham + RGFP966, CLP + vehicle, and CLP + RGFP966 groups. The HDAC3 inhibitor RGFP966 (20 mg/kg, HY-13909, MedChemExpress, Monmouth Junction, NJ, USA) or vehicle was administered to mice via subcutaneous injection.

(10) FOXA2 regulated by HDAC3-mediated deacetylation attenuates neuropathic pain by modulating microglial lipid metabolism and synaptic pruning dysregulationJournal of NeuroinflammationNovember 26, 2025Hui Zeng, Bo Wang, ZhiLin Huang, LiJie Gao, Yao Xiao, XinLi Liu, Yin Xu, ZiWei Hu, JiaHui Pang, YouXin Yu, et al.assays: 10 mM sodium valproate (VPA; MedchemExpress, HY-10585) for 24 h; 15 µM RGFP966 (MedchemExpress, HY-13909) for 6 h; 1 mM TMP195 (MedchemExpress, HY-18361) for 24 h; and 10 µM EX-527 (MedchemExpress, HY-15452)

(11) Butyrate rescues chlorpyrifos-induced social deficits through inhibition of class I histone deacetylasesbioRxivOctober 23, 2025Leonardo Diaz, Ally Xinyi Kong, Ping Zhang, Jinhua Chi, Khoa Pham, Maja Johnson, Aiden Eno, Isabelle Douglas, Yuxuan Mao, James W. MacDonald, et al.Junction, NJ, USA): BRD-6929 (CAS #849234-64-6, Cat. No.: HY-100719), RGFP966 (CAS #1357389-11-7, Cat. No.: HY-13909), and PCI-34051 (CAS #950762-95-5, Cat. No.: HY-15224). Fishbook assay The Fishbook assay was run

(12) Epigenetic profiling identifies markers of endocrine resistance and therapeutic options for metastatic castration-resistant prostate cancerCell Rep MedJuly 15, 2025Tesa M. Severson, Emma Minnee, Yanyun Zhu, Karianne Schuurman, Holly M. Nguyen, Lisha G. Brown, Sini Hakkola, Renee Menezes, Sebastian Gregoricchio, Yongsoo Kim, et al.DMSO),MedChemExpress,Cat#HY-70002 Methyltrienolone (R1881),Sigma-aldrich,Cat#R0908 BRD3308,MedChemExpress,Cat#HY-19618 RGFP966,MedChemExpress,Cat#HY-13909 Disuccinimidyl glutarate (DSG),COVACHEM,Cat#13301-1 Formaldehyde solution (37%),Merck,Cat#1039991000 Protein

(13) Unraveling the role of HDAC3 as an immunotherapy prognostic biomarker and therapeutic target in advanced non-small cell lung cancerRespir ResJune 12, 2025Liyuan Dai, Liling Huang, Lin Li, Le Tang, Yuankai Shi, Xiaohong Hana specific inhibitor of HDAC3, N-(o-aminophenyl)carboxamide, purchased from MedChemExpress (catalog HY-13909) [30, 31]. Male C57BL/6 mice (6–8 weeks old) were sourced from Shanghai GemPharmatech. These mice were

(14) Histone deacetylase 3 deletion in alveolar type 2 epithelial cells prevents bleomycin-induced pulmonary fibrosisClinical EpigeneticsNovember 11, 2023Rui Xiong, Boxin Geng, Wenyang Jiang, Yong Hu, Zhaoyu Hu, Bo Hao, Ning Li, Qing Gengantibodies Bleomycin hydrochloride (HY-17565A), (E)-SIS3(HY-13013), SB-431542 (HY-10431), RGFP966 (HY-13909) and cycloheximide (HY-12320) were purchased from MedChemExpress (Shanghai, China). Antibodies against

(15) c-Myc Targets HDAC3 to Suppress NKG2DL Expression and Innate Immune Response in N-Type SCLC through Histone DeacetylationCancersJanuary 18, 2022Zhao P, Sun X, Li H, Liu Y, Cui Y, Tian L, Cheng Y.studies. The H2227 and H446 cells transfected with MYC-OE plasmid for 48 h were incubated with RGFP966 (HY-13909, MCE, Monmouth Junction, NJ, USA). After 48 h, the cells were collected for flow cytometry analysis. 2.5.

(16) Histone deacetylase 3 inhibition alleviates type 2 diabetes mellitus-induced endothelial dysfunction via Nrf2Cell communication and signaling : CCSMarch 18, 2021Huang S, Chen G, Sun J, Chen Y, Wang N, Dong Y, Shen E, Hu Z, Gong W, Jin L, et al.dimethyl sulfoxide (DMSO; Sigma-Aldrich, D8418); 3) ad libitum feeding of chow diets and RGFP966 (MCE, HY-13909) 10 mg/kg was subcutaneously injected into the mice every other day for 10 weeks[31]. RGFP966′s formula

(17) HDAC1 and 2 regulate endothelial VCAM-1 expression and atherogenesis by suppressing methylation of the GATA6 promoterTheranosticsJanuary 1, 2021Hu C, Peng K, Wu Q, Wang Y, Fan X, Zhang DM, Passerini AG, Sun C.Medium-2 (Lonza) supplemented with 10% FBS (GIBCO). HDAC inhibitor Romidepsin (HY-15149), RGFP966 (HY-13909) and PCI-34051 (HY-15224), HDAC activator ITSA-1 (HY-100508) and DNMT inhibitor Decitabine (5-Aza-2'-deoxycytidine,

(18) RGFP966 Suppresses Tumor Growth and Migration Through Inhibition of EGFR Expression in Hepatocellular Carcinoma Cells in vitroDrug design, development and therapyJanuary 1, 2020Yu X, Yang F, Jiang H, Fan L.migration of HCC cells. Materials and Methods Chemicals RGFP966 was obtained from MedChemExpress (MCE, HY-13909), and was dissolved in DMSO. Cell Lines and Cell Culture Human HCC cell lines were obtained from Kunming

(19) The Therapeutic Effects of Treadmill Exercise on Osteoarthritis in Rats by Inhibiting the HDAC3/NF-KappaB Pathway in vivo and in vitroFrontiers in physiologyJanuary 1, 2019Zhang H, Ji L, Yang Y, Wei Y, Zhang X, Gang Y, Lu J, Bai L.into four groups: CG, OAG, OA + RGFP966 group and RGFP966 group. The concentration of RGFP966 (MCE, HY13909) was 50 μM per knee. RGFP966 was first dissolved with DMSO and then diluted with saline (concentration

(20) HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activityBiochemical pharmacologyMay 15, 2016Leus NG, van der Wouden PE, van den Bosch T, Hooghiemstra WT, Ourailidou ME, Kistemaker LE, Bischoff R, Gosens R, Haisma HJ, Dekker FJ.

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RGFP966 from MedChemExpress

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RGFP966 from MedChemExpress

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