FICZ from MedChemExpress

Product Specs
ItemFICZ
CompanyMedChemExpress
Price $188.00Supplier Page View Company Product Page
Catalog NumberHY-12451
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.42%
TypeChemical
Molecular Weight284.31
FormulaC₁₉H₁₂N₂O
Research AreaOthers

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(1) Aryl hydrocarbon receptor-mediated transcriptional regulation of HSP70 exacerbates endoplasmic reticulum stress in lupus nephritisCell & BioscienceFebruary 22, 2026Min Wen, Jian Li, Yongzhen Li, Marady Hun, Tianqing Yang, Yang Meng, Lin Liu, Han Gong, Ying Yu, Zaiqiu Zhang, et al.University’s Animal Welfare Ethics Review (Number: CSU-2022-0133). The AHR agonist FICZ (50ug/kg, i.p. MCE, HY-12451) and inhibitor CH223191(500ug/kg, i.p. TOPSCIENCE, T2448) were utilized as animal interventions with

(2) Indole-3-lactic acid suppresses colorectal cancer via metabolic reprogrammingGut MicrobesMay 23, 2025Shizhen Zhou, Kai Wang, Jiandong Huang, Zhen Xu, Qinggang Yuan, Lixiang Liu, Zhifeng Wang, Ji Miao, Hao Wang, Tingting Wang, et al.necessary pharmacological agents, including ILA (MCE HY-113099), CH223191 (MCE HY-12684), FICZ (MCE HY-12451), and 2-DG (MCE HY-13966), in DMSO. The experimental protocol ensures that the concentration of DMSO

(3) The AhR-Ovol1-Id1 regulatory axis in keratinocytes promotes epidermal and immune homeostasis in atopic dermatitis-like skin inflammationCellular & molecular immunologyMarch 1, 2025Chen Z, Dragan M, Sun P, Haensel D, Vu R, Cui L, Zhu P, Yang N, Shi Y, Dai X.treatment For FICZ experiments, the mice were i.p. injected with 100 μg/kg FICZ (MedChemExpress, Cat# HY-12451) or DMSO in 100 μl of corn oil once daily from day 0 to day 10. For γδTCR blockade, the mice were i.p.

(4) Free fatty acid receptor-4 regulates T-cell-mediated allogeneic reaction through activating an aryl hydrocarbon receptor pathwayActa pharmaceutica Sinica. BJanuary 1, 2025Duah M, Zheng F, Shen J, Xu Y, Cao S, Yan Z, Lan Q, Wang Y, Xu K, Pan B.H-89 dihydrochloride (HY-15979A), PKC inhibitor chelerythrine chloride (HY-12048), AhR agonist FICZ (HY-12451), phorbol 12-myristate 13-acetate (PMA, HY-18739), ionomycin (HY-13434) and brefeldin A (HY-16592) were

(5) Aryl hydrocarbon receptor regulates IL-22 receptor expression on thymic epithelial cell and accelerates thymus regenerationNPJ Regenerative medicineNovember 8, 2023Shen J, Wang Y, Zheng F, Cao S, Lan Q, Xu K, Pan B.in RPMI-1640 medium (Sigma-Aldrich, Shanghai, China) containing 10% FBS for 72 h. Reagents FICZ (HY-12451), CH-223191 (HY-12684), stattic (HY-13818) and colivelin (HY-P1061A) were purchased from MedChemExpress

(6) Induction of PARP7 Creates a Vulnerability for Growth Inhibition by RBN2397 in Prostate Cancer CellsCancer Res CommunApril 1, 2023Yang C, Wierbiłowicz K, Dworak NM, Bae SY, Tengse SB, Abianeh N, Drake JM, Abbas T, Ratan A, Wotton D, et al.10-CL-BBQ (BBQ, Tocris Bioscience 63-215), 6-Formylindolo[3,2-b]carbazole (FICZ; Medchemexpress LLC HY-12451), JAK1/2 inhibitor Ruxolitinib (Ruxo, Selleck Chemical LLC S13785MG), TBK1 inhibitor GSK8612 (GSK, Medchemexpress

(7) Gut microbe-derived milnacipran enhances tolerance to gut ischemia/reperfusion injuryCell reports. MedicineMarch 21, 2023Deng F, Hu JJ, Lin ZB, Sun QS, Min Y, Zhao BC, Huang ZB, Zhang WJ, Huang WK, Liu WF, et al.443-48-1; Ampicillin,Macklin,Cat# 69-53-4; Milnacipran,MedChemExpress,Cat# HY-B0168; Ficz,MedChemExpress,Cat# HY-12451; Fluorescein isothiocyanate-dextran (FITC)-dextran,Sigma–Aldrich,Cat# 46944; Recombinant Murine IL-23,R&D Systems

(8) The soluble epoxide hydrolase inhibitor TPPU improves comorbidity of chronic pain and depression via the AHR and TSPO signalingJournal of translational medicineFebruary 2, 2023Luo A, Wu Z, Li S, McReynolds CB, Wang D, Liu H, Huang C, He T, Zhang X, Wang Y, et al.AHR inhibitor CH-223191 (10 mg/kg, HY-12684, MedChemExpress, USA) and AHR agonist FICZ (100 ug/kg, HY-12451, MedChemExpress, USA) were dissolved in corn oil and intragastrically administered as previously described

(9) Beneficial roles of the AhR ligand FICZ on the regenerative potentials of BMSCs and primed cartilage templates†RSC AdvancesApril 7, 2022Jing Huang, Yining Wang, Yi Zhou103 cells per well) and incubated in a culture medium containing 500 nM FICZ (CAS No. 172922-91-7) (HY-12451, MCE), 1 μM SR1 (CAS No. 1227633-49-9) (HY-15001, MCE) or dimethyl sulphoxide (DMSO) as a control. The

(10) Activating AhR alleviates cognitive deficits of Alzheimer's disease model mice by upregulating endogenous Aβ catabolic enzyme NeprilysinTheranosticsJanuary 1, 2021Qian C, Yang C, Lu M, Bao J, Shen H, Deng B, Li S, Li W, Zhang M, Cao C.(Wuhan, China). Diosmin (CAS No.: 520-27-4, Cat No.: HY-N0178), FICZ (CAS No.: 172922-91-7, Cat No.: HY-12451), Indole-3-acetamide (I3C) (CAS No.: 879-37-8, Cat No.: HY-W016784) and Sacubitril (Sac) (CAS No.: 149709-62-6,

(11) The highly bioactive molecule and signal substance 6-formylindolo[3,2-b]carbazole (FICZ) plays bi-functional roles in cell growth and apoptosis in vitroArchives of toxicologyOctober 1, 2017Mohammadi-Bardbori A, Bastan F, Akbarizadeh AR.

(12) Time-dependent transcriptomic and biochemical responses of 6-formylindolo[3,2-b]carbazole (FICZ) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are explained by AHR activation timeBiochemical pharmacologySeptember 1, 2016Farmahin R, Crump D, O'Brien JM, Jones SP, Kennedy SW.

(13) Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent mannerBiochemical pharmacologyJune 15, 2016Wincent E, Kubota A, Timme-Laragy A, Jönsson ME, Hahn ME, Stegeman JJ.

(14) Genome Editing of the CYP1A1 Locus in iPSCs as a Platform to Map AHR Expression throughout Human DevelopmentStem cells internationalJanuary 1, 2016Smith BW, Stanford EA, Sherr DH, Murphy GJ.

(15) The aryl hydrocarbon receptor modulates acute and late mast cell responsesJournal of immunology (Baltimore, Md. : 1950)July 1, 2012Sibilano R, Frossi B, Calvaruso M, Danelli L, Betto E, Dall'Agnese A, Tripodo C, Colombo MP, Pucillo CE, Gri G.

(16) Aryl hydrocarbon receptor imported into the nucleus following ligand binding is rapidly degraded via the cytosplasmic proteasome following nuclear exportThe Journal of biological chemistryOctober 1, 1999Davarinos NA, Pollenz RS.

(17) An investigation into the hepatic cytochrome P-450 catalysed metabolism of the anaesthetic fluroxene (2,2,2-trifluoroethyl vinyl ether)The South African journal of medical sciencesJanuary 1, 1975Marsh JA, Ivanetich KM, Bradshaw JJ, Harrison GG, Webber BL, Kaminsky LS.

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FICZ from MedChemExpress

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