Fidarestat from MedChemExpress | Biocompare.com

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Fidarestat

Description

Fidarestat (SNK 860) is an inhibitor of aldose reductase, with IC₅₀s of 26 nM, 33 µM, and 1.8 µM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) has the potential to treat diabetic disease

Product Specs
ItemFidarestat
CompanyMedChemExpress
Price $193.00Supplier Page View Company Product Page
Catalog NumberHY-105185
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.63%
TypeChemical
Molecular Weight279.22
FormulaC₁₂H₁₀FN₃O₄
Research AreaMetabolic Disease

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(1) X-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP(+) and the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivityChemico-biological interactionsFebruary 25, 2013Ruiz FX, Cousido-Siah A, Mitschler A, Farrés J, Parés X, Podjarny A.

(2) Effect of an aldose reductase inhibitor, SNK-860, on deficits in the electroretinogram of diabetic ratsExperimental physiologyNovember 1, 1995Hotta N, Koh N, Sakakibara F, Nakamura J, Hamada Y, Naruse K, Sasaki H, Mizuno K, Matsubara A, Kakuta H.

(3) Gynecologic laparoscopyObstetrics and gynecology annualJanuary 1, 1979Taylor PJ.

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