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Protein Biochemistry
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ML348
ML348 from MedChemExpress
Be the first to write a review!
Citations:
(6)
Supplier Page
Supplier Page from
MedChemExpress for
ML348
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Description
ML348 (GNF-Pf-1127) is a selective and reversible
acyl-protein thioesterase 1 (APT1)/lysophospholipase 1 (LYPLA1)
inhibitor with an
IC
50
of 210 nM, and barely inhibits LYPLA2
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
ML348
Company
MedChemExpress
Price
$87.00
Supplier Page
View Company Product Page
Catalog Number
HY-100736
Quantity
10 mM * 1 mL
Applications
Bioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity
99.97%
Type
Chemical
Molecular Weight
415.79
Formula
C₁₈H₁₇ClF₃N₃O₃
Research Area
Cancer
Add to Compare List
MedChemExpress
1 Deer Park Drive, Suite F
MONMOUTH JUNCTION
,
NJ
08852
United States
Phone
: US Tel: 609-228-6898
US Fax: 609-228-5909
EU Tel: +4686500910
Email: sales@medchemexpress.com
eu.sales@MedChemExpress.com
Company Profile
Website:
medchemexpress.com
Citations (6)
(1)
S-palmitoylation modulates ATG2-dependent non-vesicular lipid transport during starvation-induced autophagy
The EMBO Journal
March 24, 2025
Wenhui Zheng, Maomao Pu, Sai Zeng, Hongtao Zhang, Qian Wang, Tao Chen, Tianhua Zhou, Chunmei Chang, Dante Neculai, Wei Liu
Scientific,21900 TAMRA-azide,
Thermo Scientific
,
T10182
LLOMe,
MedChemExpress
,
HY-129905A
ML348
,
MedChemExpress
,
HY-100736
ML349
,
MedChemExpress
,
HY-100737
Chloroquine
(CQ),
MedChemExpress
,
HY-17589A
SYBR Green qPCR Master Mix
(2)
APT1-derived depalmitoylation of CD36 alleviates diabetes-induced lipotoxicity in podocytes
International journal of biological sciences
January 1, 2025
Wang J, Hu J, Hu H, Guan Q, Zhu Z, Yang Q, Ding G.
glucose; mannitol, 5 mM glucose + 25 mM mannitol; high glucose, 30 mM glucose).
ML348
(APT1
inhibitor
,
HY-100736
,
MCE
) was administered at 5 μM, and MG132 (proteasome
inhibitor
,
HY-13259
,
MCE
) was added at 10 µM.
Cell transfection
(3)
Palmitoyltransferase DHHC9 and acyl protein thioesterase APT1 modulate renal fibrosis through regulating β-catenin palmitoylation
Nature communications
October 21, 2023
Gu M, Jiang H, Tan M, Yu L, Xu N, Li Y, Wu H, Hou Q, Dai C.
antibodies were employed: 2-bromopalmitate (2-BP, cat: 21604, Sigma-Aldrich, St Louis, MO),
ML348
(cat:
HY-100736
,
MCE
, Shanghai, China),
Iproniazid
(cat:
HY-B0886A
,
MCE
), TGF-β1 (cat:
240-B-010-CF
,
R&D Systems
, Minneapolis,
(4)
CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis
Nature communications
September 21, 2020
Hao JW, Wang J, Guo H, Zhao YY, Sun HH, Li YF, Lai XY, Zhao N, Wang X, Xie C,
et al
.
mM. Stock solutions of PalmB (20 mM,
Merck
, 178501),
PP2
(20 mM,
MCE
,
HY-13805
),
ML348
(10 mM,
MCE
,
HY-100736
),
SP600125
(20 mM, ApexBIO, A4604), Dyngo4a (2 mM,
Abcam
,
ab120689
), and piceatannol (40 mM,
MCE
,
HY-13518
)
(5)
Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 1 (LYPLA1)
None
January 1, 2010
Adibekian A, Martin BR, Chang JW, Hsu KL, Tsuboi K, Bachovchin DA, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V,
et al
.
(6)
The effect of 2 molar urea on Jk (a-b-) red cells
Vox sanguinis
January 1, 1988
Edwards-Moulds J, Kasschau MR.
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ML348 from MedChemExpress
Supplier Page
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$87.00
Product Specs
Company Info
Citations
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