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Protein Biochemistry
Chemicals and Reagents
SAFit2
SAFit2 from MedChemExpress
Be the first to write a review!
Citations:
(6)
Supplier Page
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MedChemExpress for
SAFit2
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Description
SAFit2, a chemical probe, is a highly potent, highly selective
FK506-binding protein 51
(
FKBP51
) inhibitor with a
K
i
of 6 nM and also enhances
AKT2-AS160
binding
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
SAFit2
Company
MedChemExpress
Price
$265.00
Supplier Page
View Company Product Page
Catalog Number
HY-102080
Quantity
10 mM * 1 mL
Applications
Bioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity
99.24%
Type
Chemical
Molecular Weight
802.99
Formula
C₄₆H₆₂N₂O₁₀
Research Area
Cancer
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MedChemExpress
1 Deer Park Drive, Suite F
MONMOUTH JUNCTION
,
NJ
08852
United States
Phone
: US Tel: 609-228-6898
US Fax: 609-228-5909
EU Tel: +4686500910
Email: sales@medchemexpress.com
eu.sales@MedChemExpress.com
Company Profile
Website:
medchemexpress.com
Citations (6)
(1)
Corticosterone-linked microglial activity underpins sexually dimorphic neuroplasticity after ketamine anesthesia
Sci Adv
July 31, 2026
Alessandro Venturino, MohammadAmin Alamalhoda, Thomas Negrello, Kelly Jin, Cindy T. J. van Velthoven, Ryan John A. Cubero, Jake Yeung, Peter Koppensteiner, Bosiljka Tasic, Sandra Siegert
mice
were injected with corticosterone (20 mg/kg) (91).
SAFit2
SAFit2
(
MedChemExpress
, catalog no.
HY-102080
) was dissolved in 90% (v/v)
corn
oil and 10% (v/v) EtOH, and 20 mg/kg was injected (92).
Isoflurane
For
(2)
Psychological stress-induced systemic corticosterone directly sabotages intestinal stem cells and exacerbates colitis
Cell Discov
May 13, 2025
Xiaole Sheng, Lanfei Jin, Zhengrong Yao, Jiaji Gu, Longtao Zhu, Andi Huang, Junxuan Peng, Xin Xu, Xiaolong Ge, Wei Zhou,
et al.
intraperitoneally injected daily for 3 weeks at a dose
of 1
mg/kg. For
SAFit2
treatment,
SAFit2
(
MedChemExpress
,
HY-102080
) was dissolved in vehicle containing 10% DMSO, 40%
PEG300
, 5%
Tween-80
, and 45% saline (with the solvents
(3)
FKBP51 and FKBP52 regulate androgen receptor dimerization and proliferation in prostate cancer cells
Molecular oncology
February 1, 2022
Maeda K, Habara M, Kawaguchi M, Matsumoto H, Hanaki S, Masaki T, Sato Y, Matsuyama H, Kunieda K, Nakagawa H,
et al
.
USA), FK506 (069–06191; Wako),
SAFit1
(
HY‐102079
;
MedChemExpress
, Monmouth Junction, NJ, USA),
SAFit2
(
HY‐102080
;
MedChemExpress
), and MJC13 (SML0347; Sigma‐Aldrich). DHT was dissolved in methanol (MeOH), while FK506
(4)
Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function
Nature communications
November 23, 2017
Balsevich G, Häusl AS, Meyer CW, Karamihalev S, Feng X, Pöhlmann ML, Dournes C, Uribe-Marino A, Santarelli S, Labermaier C,
et al
.
(5)
Rapid, Structure-Based Exploration of Pipecolic Acid Amides as Novel Selective Antagonists of the FK506-Binding Protein 51
Journal of medicinal chemistry
March 24, 2016
Gaali S, Feng X, Hähle A, Sippel C, Bracher A, Hausch F.
(6)
Pharmacological Inhibition of the Psychiatric Risk Factor FKBP51 Has Anxiolytic Properties
The Journal of neuroscience : the official journal of the Society for Neuroscience
June 17, 2015
Hartmann J, Wagner KV, Gaali S, Kirschner A, Kozany C, Rühter G, Dedic N, Häusl AS, Hoeijmakers L, Westerholz S,
et al
.
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SAFit2 from MedChemExpress
Supplier Page
View Company Product Page
$265.00
Product Specs
Company Info
Citations
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