Mardepodect from MedChemExpress | Biocompare.com

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Mardepodect

Description

Mardepodect (PF-2545920) is a potent, orally active and selective PDE10A inhibitor with an IC₅₀ of 0.37 nM, with >1000-fold selectivity over other PDEs. Mardepodect can cross the blood-brain barrier

Product Specs
ItemMardepodect
CompanyMedChemExpress
Price $115.00Supplier Page View Company Product Page
Catalog NumberHY-50098
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity98.81%
TypeChemical
Molecular Weight392.45
FormulaC₂₅H₂₀N₄O
Research AreaNeurological Disease

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(1) Phosphodiesterase 10A inhibitor activity in preclinical models of the positive, cognitive, and negative symptoms of schizophreniaThe Journal of pharmacology and experimental therapeuticsNovember 1, 2009Grauer SM, Pulito VL, Navarra RL, Kelly MP, Kelley C, Graf R, Langen B, Logue S, Brennan J, Jiang L, et al.

(2) Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophreniaJournal of medicinal chemistryAugust 27, 2009Verhoest PR, Chapin DS, Corman M, Fonseca K, Harms JF, Hou X, Marr ES, Menniti FS, Nelson F, O'Connor R, et al.

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