Torin 2 from MedChemExpress

Product Specs
ItemTorin 2
CompanyMedChemExpress
Price $79.00Supplier Page View Company Product Page
Catalog NumberHY-13002
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.65%
TypeChemical
Molecular Weight432.4
FormulaC₂₄H₁₅F₃N₄O
Research AreaCancer

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(1) The E3 ligase β-TRCP1 earmarks OTUD3 for destruction to fine-tune cGAS activationJournal of Biological ChemistryApril 17, 2026Jianfeng Chen, Smaran Sivashankar, Ying Wang, Pengda Liu(HY-13902), SCH772984 (HY-50846), MK2206 (HY-108232), Palbociclib (HY-50767), BKM120 (HY-70063), Torin 2 (HY-13002), Rapamycin (HY-10219), Dasatinib (HY-10181), and Sunitinib (HY-10255A) were purchased from MedChemExpress.

(2) Comprehensive analysis of TEAD inhibition in meningioma identifies MEK and mTOR inhibition as effective combination therapies against resistant linesbioRxivMarch 30, 2026Dylan J Keiser, Meghan S Buddy, Solmaz Mojarad-Jabali, Qing Li, Missia Kohler-Skinner, Abigail G Parrish, David Gillespie, David Nix, Sheri Holmen, Howard Colman, et al.SML3686-5MG); GNE-7883 (MCE HY-147214), K-975 (MCE HY-138565); trametinib (MCE HY-10999); torin-2 (MCE HY-13002); pictilisib (MCE HY-50094); vistusertib (MCE HY-15247); everolimus (MCE HY-10218); rapamycin (MCE HY-10219);

(3) NPC2 Suppresses Osteolytic Metastasis in Lung Adenocarcinoma via the AKT/mTOR Pathway and Tumor-Osteoclast CrosstalkiScienceMarch 20, 2026Si Zhou, Ning Li, Ruping Li, Ying Ding, Yichen Zhu, Yan Pan, Yan Liu, Yingying Zhang, Hui Yang, Qiming Wangbitech,FBS500 Recombinant Murine M-CSF,PEPROTECH,#315-2 Recombinant Murine sRANK Ligand,PEPROTECH,#315-11 Torin 2,MCE,HY-13002 TRIeasyTM Total RNA extraction reagent,YEASEN,10606ES60 Hifair® III 1st Strand cDNA Synthesis SuperMix

(4) Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetesJournal of Clinical InvestigationDecember 1, 2025Theodore dos Santos, Xiao-Qing Dai, Robert C. Jones, Aliya F. Spigelman, Hannah M. Mummey, Jessica D. Ewald, Cara E. Ellis, James G. Lyon, Nancy Smith, Austin Bautista, et al.KRB containing glucose, GIP (Anaspec), alanine (Sigma), and mTOR inhibitor Torin-2 (MedchemExpress, #HY-13002), as noted in figure legends. Total hormone content was assessed by lysing islets in acid ethanol. All

(5) Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetesJ Clin InvestSeptember 30, 2025Theodore dos Santos, Xiao-Qing Dai, Robert C. Jones, Aliya F. Spigelman, Hannah M. Mummey, Jessica D. Ewald, Cara E. Ellis, James G. Lyon, Nancy Smith, Austin Bautista, et al.KRB containing glucose, GIP (Anaspec), alanine (Sigma), and mTOR inhibitor Torin-2 (MedchemExpress, #HY-13002), as noted in figure legends. Total hormone content was assessed by lysing islets in acid ethanol. All

(6) Homeostasis of branched-chain amino acids is critical for the activity of TOR signaling in ArabidopsiseLifeDecember 6, 2019Pengfei Cao, Sang-Jin Kim, Anqi Xing, Craig A Schenck, Lu Liu, Nan Jiang, Jie Wang, Robert L Last, Federica Brandizziinhibition, seedlings were incubated with 5 mM AZD-8055 (MedChemExpress, HY-10422) or 1 mM Torin2 (MedChemExpress, HY-13002) for 2 or 4 hr as the figure legends indicated. 10 mM solution of b-estradiol (Sigma-Aldrich, E8875)

(7) Homeostasis of branched-chain amino acids is critical for the activity of TOR signaling in ArabidopsisElifeDecember 6, 2019Pengfei Cao, Sang-Jin Kim, Anqi Xing, Craig A Schenck, Lu Liu, Nan Jiang, Jie Wang, Robert L Last, Federica Brandizziinhibition, seedlings were incubated with 5 mM AZD-8055 (MedChemExpress, HY-10422) or 1 mM Torin2 (MedChemExpress, HY-13002) for 2 or 4 hr as the figure legends indicated. 10 mM solution of b-estradiol (Sigma-Aldrich, E8875)

(8) mTORC signaling in hematopoiesisInternational journal of hematologyMay 1, 2016Wang X, Chu Y, Wang W, Yuan W.

(9) Interleukin-6 secretion by astrocytes is dynamically regulated by PI3K-mTOR-calcium signalingPloS oneJanuary 1, 2014Codeluppi S, Fernandez-Zafra T, Sandor K, Kjell J, Liu Q, Abrams M, Olson L, Gray NS, Svensson CI, Uhlén P.

(10) Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATRCancer researchApril 15, 2013Liu Q, Xu C, Kirubakaran S, Zhang X, Hur W, Liu Y, Kwiatkowski NP, Wang J, Westover KD, Gao P, et al.

(11) Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancerJournal of medicinal chemistryMarch 10, 2011Liu Q, Wang J, Kang SA, Thoreen CC, Hur W, Ahmed T, Sabatini DM, Gray NS.

(12) Autophagic sequestration of SQSTM1 disrupts the aggresome formation of ubiquitinated proteins during proteasome inhibitionCell death & diseaseJanuary 1, 0001"Zhang C, Huang C, Xia H, Xu H, Tang Q, Bi F."HY-10197); SB203580 (MCE, HY-10256); SB202190 (HY-10295); Rapamycin (MCE, HY-10219); Torin 2 (MCE, HY-13002); Asciminib (Topscience, T5177); BRAF inhibitor (MCE, HY-10247); Chloroquine (MCE, HY-17589A). ATG5

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Torin 2 from MedChemExpress

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Torin 2 from MedChemExpress

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