Deferiprone from MedChemExpress

Product Specs
ItemDeferiprone
CompanyMedChemExpress
Price $55.00Supplier Page View Company Product Page
Catalog NumberHY-B0568
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.97%
TypeChemical
Molecular Weight139.15
Molecule NameDeferiprone
FormulaC7H9NO2
Research AreaNeurological Disease; Inflammation/Immunology; Infection; Endocrinology; Cardiovascular Disease; Cancer

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(1) Targeting Piezo1 can improve endometrial fibrosis by inhibiting ferroptosis in endothelial cellsiScienceFebruary 20, 2026Huan Yang, Chaoxun Dou, Ruohong Pan, Yaoyao Xu, Kaixuan Zeng, Jiayu Huang, Lu Sun, Yuqing Yao, Jiancheng Wangester (Calcein-AM, GC34061, GLPBIO, Irvine, CA, USA) in combination with the iron chelator Deferiprone (HY-B0568, MCE). Briefly, cells cultured in 6-well plates were trypsinized, washed twice with PBS, and then loaded

(2) Toxoplasma gondii-induced ferroptosis contributes to acute lung injury in miceParasites & VectorsDecember 28, 2025Xiaodan Yuan, Zhenzhen Liu, Yeting Ma, Feixue Liu, Penglin Bao, Boya Du, Xu Zhang, Pengtao Gong, Nan Zhang, Jianhua Li, et al.were intragastric administrated (i.g.) daily with 100 mg/kg DFP (an inhibitor of ferroptosis; cat. no. HY-B0568; MCE, New Jersey, USA); then in the DFP + RH group mice, were challenged with 1 × 103 tachyzoites i.p.

(3) Iron accumulation in hypothalamus promotes age-dependent obesity and metabolic dysfunction of male miceMol BiomedOctober 2, 2025Xinyu Wang, Xiaoyue Xiong, Ye Xuan, Wen Tian, Liwei Chen, Zhuo Chen, Yi Zhang, Wei L. Shen, Cheng Husession. This was repeated for three days prior to DFP treatment. On experimental days, DFP (3 mg/mL; MCE, HY-B0568) was administered intranasally at a total dose of 90 µg once daily for one month using the same procedure. Hypothalamic

(4) Potent antioxidant and mitochondrial-protective effects of ATH434, a moderate affinity iron chaperoneThe Journal of biological chemistrySeptember 1, 2025Bailey DK, Nihlawi R, Bradbury MJ, Bond S, Kosman DJ.procedures Reagents ATH434 and ATH434-met were provided by Alterity Therapeutics (Melbourne, AUS). DFP (Cat. #HY-B0568), DFX (Cat. #HY-17359), 8-Quinolinol (Cat. #HY-B1005) were purchased from MedChemExpress. Trolox (Cat.

(5) Co‑treatment with triptolide and RSL3 induces hepatocellular carcinoma cell apoptosis and ferroptosisMol Med RepMay 13, 2025Weixia Liu, Guodi Wu, Jing Wang, Shanshan Wu, Zhi ChenHY-100579; MedChemExpress) or a potent free iron chelating agent Deferiprone (DEF) (100 µM) (cat. no. HY-B0568; MedChemExpress) to evaluate if co-treatment with TPL and RSL3 enhances ferroptosis. After that, Hep3B

(6) Uncovering the role of ferroptosis in Bietti crystalline dystrophy and potential therapeutic strategiesCell Communication and SignalingJuly 11, 2024Chang Shen, Qianjie Yang, Kuangqi Chen, Huiling Ma, Xiawei Wang, Jianping Tong, Ye Shen, Hongguang CuiD12492, Research Diets, USA) was used for the high fat diet (HFD). Iron chelator, deferiprone (DFP, HY-B0568, MedChemExpress, Shanghai, China), was soluted at 1 mg/ml and added to mice’s drinking water. The DFP

(7) JWA binding to NCOA4 alleviates degeneration in dopaminergic neurons through suppression of ferritinophagy in Parkinson's diseaseRedox BiologyJuly 1, 2024Xinxin Zhao, Zhengwei Kang, Ruixue Han, Min Wang, Yueping Wang, Xin Sun, Cong Wang, Jianwei Zhou, Lei Cao, Ming Ludopamine-like neurons. Differentiated SH-SY5Y cells were pretreated with deferiprone (DFO, 0.1–500 μM, HY-B0568, MedChemExpress) for 1 h, followed by MPP + treatment (500 μM) for 24 h. In Erastin-induced ferroptosis

(8) O-GlcNAcylation regulates the stability of transferrin receptor (TFRC) to control the ferroptosis in hepatocellular carcinoma cellsRedox BiologyJuly 1, 2024Xunyu Zhou, Yida Wang, Xiaoyu Li, Jing Zhou, Wanyi Yang, Xin Wang, Sitong Jiao, Weibo Zuo, Ziming You, Wantao Ying, et al.PUGNAc (Sigma, #A7229), Cycloheximide (Selleck, #S7418), MG132 (Selleck, #S2619), Deferiprone (MCE, #HY-B0568). OGA-OE, TFRC-WT, and TFRC mutant (K665R or S687A) plasmids were constructed on PLVX-puro lentiviral

(9) n-3 polyunsaturated fatty acids delay intervertebral disc degeneration by inhibiting nuclear receptor coactivator 4-mediated iron overloadiScienceFebruary 16, 2024Xiang Ao, Tao Jiang, Yuan Li, Weiyi Lai, Zhengnan Lian, Liang Wang, Minjun Huang, Zhongmin ZhangII,Takara,RR820A Recombinant Murine IL-1β,Peprotech,211-11B Docosahexaenoic acid,MCE,HY-B2167 Deferiprone,MCE,HY-B0568 Ferric ammonium citrate,MCE,HY-B1645 Wnt agonist,MCE,HY-114321 XAV-939,MCE,HY-15147 ,, Critical

(10) Mitochondrial calcium transport during autophagy initiationMitochondrial CommunicationsFebruary 13, 2024Sujyoti Chandra, Parul Katiyar, Aarooran S. Durairaj, Xinnan Wang(HY-B1756, MedChemExpress), 10 (HEK cells) or 100 μM (neurons) Antimycin A (A8674, Sigma-Aldrich), 1 mM DFP (HY-B0568, MedChemExpress), 1 μM Rapamycin (HY-10219, MedChemExpress), or 100 mUnits/ml Thrombin (10602400001,

(11) A mitochondrial inside-out iron-calcium signal reveals drug targets for Parkinson's diseaseCell reportsDecember 26, 2023Bharat V, Durairaj AS, Vanhauwaert R, Li L, Muir CM, Chandra S, Kwak CS, Le Guen Y, Nandakishore P, Hsieh CH, et al.Sigma-Aldrich), 40 μM CCCP (C2759, Sigma-Aldrich), 100 μM VitC (A5960, Sigma-Aldrich), or 100 μM DFP (HY-B0568, MedChemExpress). iPSC culture and transfection All iPSC lines in this study were fully characterized

(12) Deferoxamine attenuates visual impairment in retinal ischemia‒reperfusion via inhibiting ferroptosisScientific ReportsNovember 17, 2023Xiaoxuan Wang, Mingran Li, Ke Diao, Yan Wang, Hong Chen, Ziqi Zhao, Yuan Li, Xin Jia, Hao Wang, Fangyuan Zheng, et al.normal saline. Rats in the deferoxamine treatment group were administered deferoxamine (100 mg/kg, MCE, HY- B0568) via intraperitoneal injections for the first time 1 h before anesthesia and then once every 12 h after

(13) Iron deficiency-induced ferritinophagy impairs skeletal muscle regeneration through RNF20-mediated H2Bub1 modificationScience advancesNovember 15, 2023Che Y, Li J, Wang P, Yu W, Lin J, Su Z, Ye F, Zhang Z, Xu P, Xie Z, et al.reagents The following commercially available reagents were used for this study: DFO (HY-B0988, MCE), DFP (HY-B0568, MCE), 3-MA (5142-23-4, Sigma-Aldrich), DC661 (D881024-2, Macklin), AFC (MB2808, Meilunbio), MG132 (T215-4,

(14) Mesenchymal stem cell attenuates spinal cord injury by inhibiting mitochondrial quality control-associated neuronal ferroptosisRedox BiologyNovember 1, 2023Senyu Yao, Mao Pang, Yanheng Wang, Xiaokang Wang, Yaobang Lin, Yanyan Lv, Ziqi Xie, Jianfeng Hou, Cong Du, Yuan Qiu, et al.measured by calcein-acetoxymethyl ester (Calcein-AM, GC34061, GLPBIO) cooperated with deferiprone (HY–B0568, MCE). After trypsinization, cells (6-well dishes) were washed twice with PBS and then incubated with

(15) Taurine and deferiprone against Al-linked apoptosis in rat hippocampusJournal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)March 1, 2023Zhang Y, Guo T, Ding Y, Wang X, Liu P.

(16) Iron metabolism mediates the relationship between Vitamin C and hepatic steatosis and fibrosis in NAFLDFrontiers in NutritionSeptember 8, 2022Zhengyu Hu, Yan Li, Bingwei Ma, Saifei Lei, Xingchun WangBiosciences, λex 488 nm; λem 530 nm). Following this the cells were incubated with 100 μM deferiprone (HY-B0568, MedChemExpress, USA) at 37°C for 40 min (Shake every 5 min to avoid cell clumping) fully bind the free

(17) Tetrandrine Citrate Suppresses Breast Cancer via Depletion of Glutathione Peroxidase 4 and Activation of Nuclear Receptor Coactivator 4-Mediated FerritinophagyFrontiers in pharmacologyJanuary 1, 2022Yin J, Lin Y, Fang W, Zhang X, Wei J, Hu G, Liu P, Niu J, Guo J, Zhen Y, et al.Shanghai, China), Chloroquine (CQ) (HY-17589A, MedChemExpress, Shanghai, China), deferiprone (DFO) (HY-B0568, MedChemExpress, Shanghai, China), and acetylcysteine (NAC) (HY-B0215, MedChemExpress, Shanghai, China).

(18) Deferiprone Treatment in Aged Transgenic Tau Mice Improves Y-Maze Performance and Alters Tau PathologyNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeuticsApril 1, 2021Rao SS, Lago L, Volitakis I, Shukla JJ, McColl G, Finkelstein DI, Adlard PA.

(19) Deferiprone Stimulates Aged Dermal Fibroblasts via HIF-1α ModulationAesthetic surgery journalMarch 12, 2021Pagani A, Kirsch BM, Hopfner U, Aitzetmueller MM, Brett EA, Thor D, Mela P, Machens HG, Duscher D.

(20) Antiplatelet activity of deferiprone through cyclooxygenase-1 inhibitionPlateletsMay 18, 2020Tran NT, Akkawat B, Morales NP, Rojnuckarin P, Luechapudiporn R.

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Deferiprone from MedChemExpress

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Deferiprone from MedChemExpress

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