DMOG from MedChemExpress

Product Specs
ItemDMOG
CompanyMedChemExpress
Price $87.00Supplier Page View Company Product Page
Catalog NumberHY-15893
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.69%
TypeChemical
Molecular Weight175.14
FormulaC₆H₉NO₅
Research AreaCancer

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(1) Dahuang Zhechong pill alleviates pulmonary fibrosis by inhibiting apoptosis and epithelial-mesenchymal transition of type II alveolar epithelial cells in vitro and in vivoJournal of Traditional and Complementary MedicineMarch 1, 2026Fang Sun, Zhaochu Wu, Song Cai, Xiaoming Xing, Jing Wang, Lishan ZhangX-100 (#ST797) was purchased from China Beyotime Biotechnology Co., Ltd. (Shanghai, China). DMOG (#HY-15893), TGF-β1 (#HY-P70543), and SAG (#HY-12848) were purchased from MCE, USA. The following antibodies were

(2) Phase separation of OPTN initiates mitophagy to orchestrate craniofacial bone mineralizationAutophagyFebruary 15, 2026Haojie Liu, Zhenyi Lu, Xinyu Zhang, Yan Wang, Xiao Ge, Simai Chen, Yumeng Shi, Jingjing Yan, Rongyao Xu, Junqing Ma, et al.medium starting from 24 hpf. For inducing mitophagy and inhibiting phase separation, DMOG (100 µM; MCE, HY-15893) was added to the medium to induce mitophagy, while 3% 1,6-hexanediol (HD; Sigma-Aldrich, 240,117) was

(3) Porcine epidemic diarrhea virus promotes viral replication via ROS/HIF-1α-mediated glycolysisRedox BiologyFebruary 1, 2026Yafang Xu, Jinqiu Zhang, Chengwei Yin, Laizhen Liu, Zhenglei Wang, Shaodong Fu, Rong Fan, Yanyan Zhao, Jinfeng MiaoSelleck Chemicals (China). KC7F2 (HIF-1α inhibitor, HY-18777), dimethyloxalylglycine (DMOG, HIF-1α activator, HY-15893), N-Acetyl-l-cysteine (NAC; HY-B0215), Rotenone (ROT; HY-B1756), and Carbonyl cyanide 3-chlorophenylhydrazone

(4) Long non-coding RNA LINC00607 epigenetically regulates endothelial TSPAN18 to promote hypoxia-induced thromboinflammationJournal of Biological ChemistryJanuary 23, 2026MOHD YASIR KHAN, KASHIKA SINGH, ALIA HASHMI, ARMIYA SULTAN, KHAN SADIA, MOHAMMAD ZAHID ASHRAFHIF1α stabilization under normoxia, cells were treated with 0.5 mM dimethyloxalylglycine (DMOG; MCE; HY-15893) for 24 h. The functional role of BRG1 during hypoxic responses was evaluated by treating cells with

(5) Acetylbinankadsurin A Decreases Macrophage Glycolysis and Pro-Inflammatory Phenotype Polarization via Inhibiting HIF-1α to Alleviate Hepatic Fibrosis in MiceMoleculesNovember 27, 2025Qiang Yao, Wangxia Peng, Huaguan Lu, Yupei Yang, Ziti Rao, Xin Xie, Dan Huang, Wei Wang, Jianye Yan, Jianjun LiuNJ, USA, #HY-P74888), CM5 chip (Cytiva, Uppsala, Sweden, #29104988), DMOG (MCE, Junction, NJ, USA, #HY-15893), ELISA kits (Elabscience, Wuhan, China, #E-EL-M3063, #E-EL-M0044c, #E-BC-235-M, #E-BC-K236-M), Seahorse

(6) Kaempferide inhibited progression of osteoarthritis by targeting the HIF-1 signaling pathwayChinese Medical JournalNovember 5, 2025Xianjie Wei, Hesuyuan Huang, Ping Yuan, Peisen Xie, Keshi Zhang, Zhenpeng Guan(AF5851), were obtained from Beyotime (Shanghai, China). The HIF-1α agonist dimethyloxallyl glycine (DMOG, HY-15893) and the HIF-1α inhibitor LW6 (HY-13671) were both supplied by MedChemExpress (Monmouth Junction, NJ,

(7) The Glycolysis-HIF-1α axis induces IL-1β of macrophages in rheumatoid arthritisArthritis Research & TherapySeptember 26, 2025Yimeng Jia, Rongli Li, Linfang Huang, Xunyao Wu, Lidan Zhao, Huaxia Yang, Xin You, Yunyun Feiinhibition of HIF-1α, HMDMs were pretreated with 100 µM of Dimethyloxallyl Glycine (DMOG, MedChemExpress, HY-15893) and 20 µM of LW6 (HY-13671, MedChemExpress) for 3 h, respectively. For cytokine blocking, HMDMs were

(8) pVHL regulates protein stability of the TCF/LEF transcription factor family via ubiquitin-independent proteasomal degradationCellular and Molecular Life SciencesSeptember 4, 2025Caixia Wang, Xiaozhi Rong, Haifeng Zhang, Bo Wang, Yan Bai, Yonghua Sun, Chengtian Zhao, Jianfeng Zhou3-Methyladenine (3-MA, M9281) was purchased from Sigma (St. Louis, MO, USA). Dimethyloxallyl Glycine (DMOG, HY-15893) was purchased from MedChemExpress (Monmouth, NJ, USA). The polyethylenimine (#23966–2) was purchased

(9) PARylation promotes acute kidney injury via RACK1 dimerization-mediated HIF-1α degradationActa Pharmaceutica Sinica BSeptember 1, 2025Xiangyu Li, Xiaoyu Shen, Xinfei Mao, Yuqing Wang, Yuhang Dong, Shuai Sun, Mengmeng Zhang, Jie Wei, Jianan Wang, Chao Li, et al.(B1582), OICR9429 (B6168), and PJ34 (A3729) were purchased from APExBIO. PDD (HY-108360) and DMOG (HY-15893) were purchased from MedChemExpress (Monmouth Junction, NJ, USA). Cisplatin (p4393) was purchased from

(10) KLF4 overexpression protects against complement-mediated endothelial injury in transplant-associated thrombotic microangiopathyHaematologicaAugust 7, 2025Jiang S, Qi J, Pan T, Yao Z, Lu S, Han Y, Wu D, Han Y.DMOG-based model previously described by our group. Specifically, DMOG (800 mg/kg body weight; MCE, #HY-15893) or vehicle control (0.9% saline) was administered intraperitoneally once daily for two consecutive

(11) HIF-1α alleviates ferroptosis in ulcerative colitis by regulation of GPX4Cell Death DisJuly 22, 2025Weitao Hu, Yanliang Cai, Daxing Cai, Zongchi Chen, Siying Huang, Su Zhang, Huie Zhuang, Taiyong Fang, Xiaoqing Chendaily drinking water for 7 days. To stabilize HIF-1α, 8 mg dimethyloxallyl glycine (DMOG; MCE; Cat. HY-15893) was administered intraperitoneally on alternate days. To inhibit the activity of HIF-1α, 2-methoxyestradiol

(12) Neuraminidase 1 Exacerbated Glycolytic Dysregulation and Cardiotoxicity by Destabilizing SIRT1 through Interactions with NRF2 and HIF1αAdvanced ScienceMay 24, 2025Ting Gao, Yufeng Tang, Tao Zeng, Jie Wang, Xiaohui Zhang, Qingbo Liu, Xun Guan, Xinyu Tang, Guangping Lu, Jiahao Li, et al.were transfected with various plasmids for 24 h, following by treatment with DOX and/or DMOG (Cat# HY‐15893, MedChemExpress, USA). Subsequently, the Glycolytic Rate assay was conducted according to the instructions,

(13) A Critical Role for the Mitochondrial Pyruvate Carrier in Hepatic Stellate Cell ActivationCellular and Molecular Gastroenterology and HepatologyApril 14, 2025Mohammad Habibi, Daniel Ferguson, Sophie J. Eichler, Mandy M. Chan, Christina Fu, Terri A. Pietka, Andrea L. Bredemeyer, Andrew LaPoint, Trevor M. Shew, Mai He, et al.(Millipore-Sigma; 90790), BPTES (Cayman; 19284), CB-839 (MedChemExpress; HY-12248), and DMOG (MedChemExpress; HY-15893). For Seahorse assays, LX2 cells were seeded at 4 × 104 cells/well in an Agilent Seahorse XF24 Microplate

(14) Gua Sha Alleviates Radiculitis-Induced Pain Via HIF-1α-Mediated Metabolic Reprogramming Pathway in RatsPain Res ManagMarch 17, 2025Haotian Ge, Shuxia Yan, Mingwan Yin, Yujie Gao, Jiayi Wang, Qin Wang, Guihua Xu, Min Yangdimethyloxallyl glycine (DMOG). 2. Materials and Methods 2.1. Main Reagents and Antibodies DMOG (HY-15893) and YC-1 (HY-14927) were purchased from MedChemExpress (Shanghai, China). The HypoxyprobeTM-1 Plus

(15) Hypoxia Regulates the Proliferation and Apoptosis of Coronary Artery Smooth Muscle Cells Through HIF-1α Mediated Autophagy in YakBiomoleculesFebruary 10, 2025Shanshan Yang, Yan Cui, Rui Ma, Sijiu Yu, Hui Zhang, Pengfei Zhao, Junfeng Henormoxia treatment, the cells were treated with 200 μM HIF-1α activator dimethyloxallyl glycine (DMOG, HY-15893, MedChemExpress, Monmouth Junction, NJ, USA), 25 μM inhibitor (LW6, HY-13671, MedChemExpress), 20 μM

(16) Molecular mechanism of infectious spleen and kidney necrosis virus in manipulating the hypoxia-inducible factor pathway to augment virus replicationVirulenceDecember 31, 2024Jian He, Yang Yu, Wenhui Liu, Zhimin Li, Zhang Qi, Shaoping Weng, Changjun Guo, Jianguo HeStrains,, ISKNV,This study, "Chemicals, Peptides, and Recombinant Proteins",, DMSO,MP,196055 DMOG,MCE,HY-15893 BAY87–2243,MCE,HY-15836 MG132,Sigma-Aldrich,M8699-1 MG CHX,MCE,HY-12320 Critical Commercial Assays,, Dual

(17) Framework Nucleic Acids‐Based VEGF Signaling Activating System for Angiogenesis: A Dual Stimulation StrategyAdvanced ScienceJune 1, 2024Yichen Ge, Qingxuan Wang, Yangxue Yao, Qin Xin, Jiafei Sun, Wen Chen, Yunfeng Lin, Xiaoxiao Caiwas added and incubated at 37 °C for 4 h, then followed by ultrafiltration to obtain TAC. The DMOG (HY‐15893‐27218, MCE, USA) solution was added to the TAC solution (250 µm DMOG and 250 nm TAC for cellular application

(18) Intermittent short-duration reoxygenation relieves high-altitude pulmonary hypertension via NOX4/H2O2/PPAR-γ axisClinical ScienceFebruary 7, 2024Shaohua Li, Qiang Lyu, Qixin Shi, Yungang Bai, Xinling Ren, Jin Maused for PASMCs included 100 or 200 μM dimethyloxallyl glycine (DMOG, a stabilizer of HIF-1α, MCE, HY-15893), 3 mM (0.01%) H2O2 (Sigma, 323381), 5 μM GLX351322 (an inhibitor of NOX4, MCE, HY-100111), 20 μM T0070907

(19) Epigenetic drug screening for trophoblast syncytialization reveals a novel role for MLL1 in regulating fetoplacental growthBMC MedicineFebruary 5, 2024Jiayi Wu, Chuanmei Qin, Fuju Tian, Xueqing Liu, Jianing Hu, Fan Wu, Cailian Chen, Yi Linsignificant HIF1A enrichment in the promoter region of MLL1. Dimethyloxallyl glycine (DMOG; MedChemExpress, HY-15893), a low-toxicity compound often employed to simulate hypoxia in cells and tissues, further enhanced

(20) β-Patchoulene represses hypoxia-induced proliferation and epithelial-mesenchymal transition of liver cancer cellsBioengineeredMay 12, 2022Huahua Tu, Wei Wang, Yanqing Feng, Linfei Zhang, Huadong Zhou, Caitao Cheng, Lei Ji, Qinghe Cai, Yong Fenghypoxia-induced HCC cells were dealt with the HIF-1α agonist Dimethyloxaloglycine (DMOG) (Article No. HY-15893, Concentration: 200 μM, Company: MedChemExpress, NJ, USA). Compared with the β-PAE group, cell viability

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DMOG from MedChemExpress

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