WNK463 from MedChemExpress

Product Specs
ItemWNK463
CompanyMedChemExpress
Price $102.00Supplier Page View Company Product Page
Catalog NumberHY-100626
Research AreaCancer
FormulaC₂₁H₂₄F₃N₇O₂
Molecular Weight463.46
TypeChemical
Purity99.75%
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Quantity10 mM * 1 mL

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(1) The WNK-OXSR1 osmosensing pathway mediates intestinal regeneration via Hippo-YAP signalingThe EMBO JournalMarch 18, 2026Heming Cao, Xiawei Huang, Xiaobing Jiang, Jingrong Deng, Jiahui Wang, Chengfang Wu, Minhuang Hu, Bei Zeng, Zhihao Hu, Huimin Pan, et al.Bumetanide (MCE #HY-17468), Chlorothiazide (MCE #HY-B0224), CLP-290 (MCE #HY-103023), WNK463 (MCE #HY-100626), and Rafoxanide (MCE #HY-17598). Brilliant Blue FCF (Millipore Sigma #3844-45-9), Dextran sulfate sodium

(2) Knock-down of the long isoform of the WNK1 kinase mitigates the anti-glomerular basement membrane glomerulonephritis in miceScientific ReportsFebruary 5, 2026Cyril Mousseaux, Tiffany Migeon, Perrine Frère, Nadhir Yousfi, Souhila Ouchelouche, Thomas Mouche, Marie-Christine Verpont, Brigitte Surin, Liliane Louedec, David Buob, et al.podocytes were cultured in the presence or the absence of the WNK inhibitor WNK463 (1µM, MedChemExpress, HY-100626) for 4 h. Primary mouse PEC line were culture in a RPMI-1640 based medium supplemented with 20% FBS

(3) WNK1 signalling regulates amino acid transport and mTORC1 activity to sustain acute myeloid leukaemia growthNat CommunMay 27, 2025Shunlei Duan, Karl Agger, Jan-Erik Messling, Koutarou Nishimura, Xuerui Han, Isabel Peña-Rømer, Pavel Shliaha, Helene Damhofer, Max Douglas, Manas Kohli, et al.4-Hydroxytamoxifen (OHT) (H7904) were purchased from Sigma, Rapamycin (S1039) from Selleck Chemicals, WNK463 (HY-100626) from MedChemExpress. For in vitro experiments, the compounds were dissolved in DMSO, except for OHT,

(4) Multiplexed single-cell lineage tracing of mitotic kinesin inhibitor resistance in glioblastomaCell ReportsMay 28, 2024Yim Ling Cheng, Matei A. Banu, Wenting Zhao, Steven S. Rosenfeld, Peter Canoll, Peter A. Simsproteins" ,, ispinesib,MedChemExpress,HY-50759 URMC-099,MedChemExpress,HY-12599 WNK463,MedChemExpress,HY-100626 tomocamycin,MedChemExpress,HY-103248 NVP231,MedChemExpress,HY-13945 LMK-235,MedChemExpress,HY-18998 pentostatin,MedChemExpress,HY-A0006 monensin

(5) WNK1 is an assembly factor for the human ER membrane protein complexMolecular cellJuly 1, 2021Pleiner T, Hazu M, Tomaleri GP, Januszyk K, Oania RS, Sweredoski MJ, Moradian A, Guna A, Voorhees RM.474790 Bortezomib,Calbiochem,"Cat# 504314, CAS 179324-69-7" PR619,Sigma-Aldrich,Cat# SML0430 WNK463,MedChemExpress,"Cat# HY-100626, CAS 2012607-27-9" 4-Benzoylphenylalanine (Bpa),Bachem,"Cat# 4017646.0001, CAS 104504-45-2" DAPI,Sigma-Aldrich,Cat#

(6) Contribution of the WNK1 kinase to corneal wound healing using the tissue-engineered human cornea as an in vitro modelJournal of tissue engineering and regenerative medicineSeptember 1, 2019Desjardins P, Couture C, Germain L, Guérin SL.

(7) Slc12a8 is a nicotinamide mononucleotide transporterNature metabolismJanuary 1, 2019Grozio A, Mills KF, Yoshino J, Bruzzone S, Sociali G, Tokizane K, Lei HC, Cunningham R, Sasaki Y, Migaud ME, et al.500 μM AOPCP, 100 nM FK866, and in some experiments, 10 μM WNK463, a pan-WNK kinase inhibitor (MCE, # HY-100626), for 1h and then with the same inhibitors combined with 100 μM NMN for an additional 1h in DMEM 1%FBS

(8) Small-molecule WNK inhibition regulates cardiovascular and renal functionNature chemical biologyNovember 1, 2016Yamada K, Park HM, Rigel DF, DiPetrillo K, Whalen EJ, Anisowicz A, Beil M, Berstler J, Brocklehurst CE, Burdick DA, et al.

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WNK463 from MedChemExpress

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WNK463 from MedChemExpress

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