FCCP from MedChemExpress

Product Specs
ItemFCCP
CompanyMedChemExpress
Price $80.00Supplier Page View Company Product Page
Catalog NumberHY-100410
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.70%
TypeChemical
Molecular Weight254.17
Molecule NameFCCP
FormulaC10H5F3N4O
Research AreaCancer

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(1) WAT-to-BAT communication facilitates the sustained activation of BAT thermogenesis during cold exposureCell DiscovMay 26, 2026Jieyuan Xue, Ding Chen, Chenfeng Wang, Jue Wang, Jiayu Zhou, Wenyan Li, Junxi Qian, Yuanji Huang, Liang Fang, Hongyong Song, et al.cell culture medium to assess the basal OCR. Subsequently, 5 mg/mL oligomycin A (Selleck, S1478) and 5 μM FCCP (MCE, HY-100410) were added to measure the uncoupled and maximum OCRs, respectively. The OCRs were calculated using

(2) Ubiquitin-specific protease 26 facilitates endochondral ossification by driving chondrocyte hypertrophy and mineralizationBone ResApril 9, 2026Changwei Li, Yiming Xu, Li Zhou, Leilei Chang, Zhou Dan, Yunhe Jiang, Chao Wang, Lianfu Deng, Guoqing Tanginorganic phosphate (Pi) for 2 days. In order to inhibit mitochondrial function, either FCCP (MCE Cat. #HY-100410, 1 μmol/L) or Oligomycin A (MCE Cat. #HY-16589, 2 μmol/L) was added to the culture medium. Mouse OA

(3) Incubation of brain organoids with fluorescent carbon nanodotsRSC AdvApril 8, 2026Carla Sprengel, Ute Fischer, Arndt Borkhardt, Rainer Haas, Thomas Heinzelenzymatic method. For staining with the JC-1 dye (MedChemExpress, #HY-15534) and FCCP (MedChemExpress, #HY-100410) incubation, after the described dissociation, the cells were re-suspended in organoid medium and 100

(4) Amino acid restriction sensitizes lung cancer cells to ferroptosis via GCN2-dependent activation of the integrated stress responseRedox BiologyMarch 1, 2026Viktor Antonsson Garellick, Nadia Gul, Parvin Horrieh, Dyar Mustafa, Angana A.H. Patel, Martin Dankis, Samantha W. Alvarez, Johanna Berndtson, Saeed Mahdavi, Maria Schwarz, et al.Sigma-Aldrich), erastin (e7781; Sigma Aldrich), FCCP (Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone) (HY-100410; MedChemExpress), ferrostatin-1 (SML0583; Sigma-Aldrich), l-buthionine-sulfoximine (b2515; Sigma-Aldrich),

(5) Silencing of the Metabolic Gene HKDC1 Is Associated With Aging and Neurodegeneration in Mice and HumansAging CellFebruary 24, 2026Zeenat Farooq, Vladimir Ilievski, James Boyett, Julianne Jorgensen, Yang Pan, Tanika Kelly, David Bennett, Orly Lazarov, Brian T. Laydenwell, respectively, overnight. At 20 h post‐transfection, cells were treated with FCCP (MedChemExpress; HY‐100410) according to their experimental group for protein isolation or quantification of ROS production, respectively.

(6) HVEM costimulatory domain boosts CAR T cell efficacy against solid tumors via enhanced TRAF-mediated TNF signalingCell Communication and SignalingJanuary 8, 2026Shishuo Sun, Wanxin Zhao, Yibing Liang, Ying Xue, Qihong Li, Yifan Yuan, Zhenyu Wang, Xiaoge Gao, Yizhou Yao, Haiheng Xu, et al.1.5 µM oligomycin (HY-N6782, MCE), 1.0 µM carbonyl cyanide p-trifluoromethoxy phenylhydrazone (FCCP; HY-100410, MCE), 40 nM rotenone (HY-B1756, MCE), and 1 mM antimycin A (A8674, Sigma) every 20 min to detect the

(7) FSP1 and histone deacetylases suppress cancer persister cell ferroptosisSci AdvJanuary 2, 2026Masayoshi Higuchi, August F. Williams, Anna E. Stuhlfire, Ariel H. Nguyen, David A. G. Gervasio, Claire E. Turkal, Suejean Chon, Matthew J. Hangauertrametinib (HY-10999), metformin (HY-B0627), mitoTEMPO (HY-112879), IACS-010759 (HY-112037), FCCP (HY-100410), and BAY2402234 (HY-112645) were purchased from MedChemExpress. All chemicals except for BSO and metformin,

(8) Mechanical confinement induces ferroptosis through mitochondrial dysfunctionNature CommunicationsNovember 28, 2025Fang Zhou, Robert J. Ju, Chenlu Kang, Jiayi Li, Ao Yang, Alexandre Libert, Yujie Sun, Ling Liang, Youwei Ai, Xiaoqing Hu, et al.Ferrostatin-1 (S7243), and MitoTEMPO (S9733) were from Selleckchem. Trolox (ab120747) was from Abcam. FCCP (HY-100410), CAY10650 (HY-10801), BAPTA-AM (HY-100545), MitoSOX Red (HY-D1055), Rotenone (HY-B1756), and Arachidonic acid

(9) p53-mediated regulation of electron transport chain and nucleotide synthesis during Newcastle disease virus infectionJournal of VirologyNovember 25, 2025Changrun Zhao, Ning Tang, Jing Wang, Yang Qu, Lei Tan, Cuiping Song, Xusheng Qiu, Ying Liao, Tingrong Luo, Chan Ding, et al.purchased from Beyotime. Rotenone (HY-B1756), carbonyl cyanide 4-(trifluoromethoxy) phenylhydrazone (FCCP, HY-100410), and oligomycin (HY-N6782) were purchased from MedChemExpress. Antimycin A (GC49360) was purchased

(10) Glycine decarboxylase advances IgA nephropathy by boosting mesangial cell proliferation through the pyrimidine pathwayEMBO Molecular MedicineOctober 13, 2025Yi Xiong, Fang Zeng, Kaiping Luo, Li Wang, Manna Li, Yanxia Chen, Tianlun Huang, Chengyun Xu, Gaosi Xu, Honghong Zouiodide,ThermoFisher,R37169 Glucose,Procell Life Science & Technology,PB180418 Oligomycin,MCE,HY-N6782 Mitochondrial uncoupler,MCE,HY-100410 Rotenone,MCE,HY-B1756 Antimycin A,Santa Cruz,sc-202467 Software,Software,Software GraphPad Prism

(11) PDK4-driven lactate accumulation facilitates LPCAT2 lactylation to exacerbate sepsis-induced acute lung injuryCell Death & DifferentiationOctober 7, 2025Yifan Deng, Yuetan Qiu, Xiang Li, Ting Gong, Jinyan Guo, Haoxuan Liang, Ziyi Yuan, Ziqing Hei, Xuedi Zhang, Youtan Liuwith 1 μM oligomycin, 1 μM FCCP [Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone, MedChemExpress, HY-100410], and 1 μM each of rotenone (MedChemExpress, HY-B1756) / antimycin A (MKBIO, Shanghai, China, HY-MS0070). Generation

(12) Mitophagy-mediated S1P facilitates muscle adaptive responses to endurance exercise through SPHK1-S1PR1/S1PR2 in slow-twitch myofibersAutophagyOctober 3, 2025Minghong Leng, Fenghe Yang, Junhui Zhao, Yufei Xiong, Yiqing Zhou, Mingyang Zhao, Shi Jia, Limei Liu, Qiaoxia Zheng, Lebin Gan, et al.supplemented with 2% horse serum. Differentiated C2C12 myotubes were treated with 10 µM FCCP (MCE, HY-100410) for 4 h after pretreatment with 50 µM CQ (Sigma-Aldrich, C6628) for 4 h, 50 µM NOE (MCE, HY-107542)

(13) Parkin modulates the hepatocellular carcinoma microenvironment by regulating PD-1/PD-L1 signallingJournal of Advanced ResearchOctober 1, 2025Guiqin Ye, Xin Sun, Jiuzhou Li, Maomao Pu, Jianbin ZhangTOM20(Cat No.11802–1-AP), PD-1(18106–1-AP). All chemicals were purchased from MedChemExpress: FCCP (Cat No. HY-100410), MG132(Cat No. HY-13259), Oligomycin (HY-N6782), Rotenone (HY-B1756). Antimycin A (Cat No. MS0070)

(14) Astragaloside IV Ameliorates Cerebral Ischemic-Reperfusion Injury via Improving Mitochondrial Function and Inhibiting Neuronal ApoptosisCurrent Issues in Molecular BiologyJuly 29, 2025Tongtong He, Xiaohong Zhou, Xiaorong Wang, Yanmeng Zhao, Zhenyi Liu, Ping Gao, Weijuan Gao, Xiaofei Jin(H20033549) was obtained from Shandong Fangming Pharmaceutical Group Co., Ltd. (Jinan, China); FCCP (HY-100410) was obtained from MedChemExpress (Princeton, NJ, USA); Antibodies against PINK1 (23274-1-AP) and Parkin

(15) Nucleolar proteomics revealed the regulation of RNA exosome localization by MTR4Molecular & Cellular ProteomicsJuly 10, 2025Yaqian Zhang, Guangzhen Jiang, Ke Wang, Minjie Hong, Xinya Huang, Xiangyang Chen, Xuezhu Feng, Shouhong Guangcyanide-4-(trifluoromethoxy)phenylhydrazone (FCCP) treatment, HeLa cells were incubated for 24 h in medium containing 20 μM FCCP (MCE, HY-100410). For cycloheximide (CHX) treatment, HeLa cells were incubated for 48 h in medium containing 2.8 μM

(16) Correction of pathogenic mitochondrial DNA in patient-derived disease models using mitochondrial base editorsPLoS BiolJune 24, 2025Indi P. Joore, Sawsan Shehata, Irena Muffels, Jose Castro-Alpízar, Elena Jiménez-Curiel, Emilia Nagyova, Natacha Levy, Ziqin Tang, Kimberly Smit, Wilbert P. Vermeij, et al.previously described [47], but using 1 μM Oligomycin (Merck, O4876-5MG), 1.5 μM FCCP (MedChemExpress, HY-100410), 1 μM Rotenone (MedChemExpress, HY-B1756) and 1 μM Antimycin-A (Sigma, A8674) while D-glucose and galactose

(17) Brown adipose tissue-derived extracellular vesicles regulate hepatocyte mitochondrial activity to alleviate high-fat diet-induced jawbone osteoporosis in miceFront Endocrinol (Lausanne)April 24, 2025Kai Zhang, Sha Zhang, Guorong Deng, Guangxiang He, Yuan Yuan, Yu Fu, Yihan Liu, Zhen Gong, Liang Kong, Chenxi Zhengincubation at 37°C for 1 hour. Solutions of 1 µM oligomycin (HY-N6782, MedChemExpress, America), FCCP (HY-100410, MedChemExpress, America), and rotenone (HY-B1756, MedChemExpress, America) were prepared to use. The

(18) In Vivo Reprogramming of Tissue‐Derived Extracellular Vesicles for Treating Chronic Tissue Injury Through Metabolic EngineeringAdvanced ScienceMarch 31, 2025Meng Zhao, Shuyun Liu, Yizhuo Wang, Peng Lou, Ke Lv, Tian Wu, Lan Li, Qianyi Wu, Jiaying Zhu, Yanrong Lu, et al.treated with muscle‐derived EVs (≈6 × 109 particles mL−1). To impede mitochondrial function, 10 µM FCCP (HY‐100410, MedChemExpress, Monmouth Junction, NJ, USA) was used, and 2 µM C75 (C5490, Sigma‒Aldrich, USA) was

(19) Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTPCell reportsMarch 25, 2025O'Keefe ME, Kondolf HC, De Santis S, Pizarro TT, Abbott DW.BCI hydrochloride,MedChemExpress,Cat#: HY-115502A FCCP (Carbonyl cyanide 4-(trifluoromethoxy) phenylhydrazone),MedChemExpress,Cat# HY-100410 Rotenone,MedChemExpress,Cat#: HY-B1756 Calyculin,LC Laboratories,Cat# C-3987 Okadaic acid,MedChemExpress,Cat#

(20) NDUFB7 mutations cause brain neuronal defects, lactic acidosis, and mitochondrial dysfunction in humans and zebrafishCell Death DiscovMarch 1, 2025Yen-Lin Chen, Brian Hon-Yin Chung, Masakazu Mimaki, Shumpei Uchino, Yin-Hsiu Chien, Christopher Chun-Yun Mak, Steven Shinn-Forng Peng, Wei-Chen Wang, Yu-Li Lin, Wuh-Liang Hwu, et al.administration of 8 μM carbonyl cyanide-p-trifluoromethoxyphenylhydrazone (FCCP, MedChemExpress, Cat# HY-100410), and 12 cycles after administration of 3.5 μM rotenone (Sigma Aldrich, Cat# R8875) and 3.5 μM antimycin

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FCCP from MedChemExpress

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