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Protein Biochemistry
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Pacritinib
Pacritinib from MedChemExpress
Be the first to write a review!
Citations:
(8)
Supplier Page
Supplier Page from
MedChemExpress for
Pacritinib
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Description
Pacritinib (SB1518) is a potent inhibitor of both wild-type
JAK2
(IC
50
=23 nM) and
JAK2
V617F
mutant (IC
50
=19 nM). Pacritinib also inhibits
FLT3
(IC
50
=22 nM) and its mutant
FLT3
D835Y
(IC
50
=6 nM)
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
Pacritinib
Company
MedChemExpress
Price
$77.00
Supplier Page
View Company Product Page
Catalog Number
HY-16379
Quantity
10 mM * 1 mL
Applications
Bioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity
99.93%
Type
Chemical
Molecular Weight
472.58
Molecule Name
Pacritinib
Formula
C28H32N4O3
Research Area
Cancer
Add to Compare List
MedChemExpress
1 Deer Park Drive, Suite F
MONMOUTH JUNCTION
,
NJ
08852
United States
Phone
: US Tel: 609-228-6898
US Fax: 609-228-5909
EU Tel: +4686500910
Email: sales@medchemexpress.com
eu.sales@MedChemExpress.com
Company Profile
Website:
medchemexpress.com
Citations (8)
(1)
JAK inhibitors remove innate immune barriers facilitating viral propagation
NAR Molecular Medicine
May 2, 2025
Erlend Ravlo, Aleksandr Ianevski, Marius Nårstad Skipperstøen, Hilde Lysvand, Jørn-Ove Schjølberg, Ole Solheim, Wei Wang, Miroslava Kissova, Marthe Vestvik, Olli Vapalahti,
et al.
fedratinib (
HY-10409
), filgotinib (
HY-18300
), itacitinib (
HY-16997
), oclacitinib (
HY-13577
), pacricitinib (
HY-16379
), ruxolitinib (
HY-50856
), tofacitinib (
HY-40354
), and upadacitinib (
HY-19569
) were obtained from
MedChemExpress
.
(2)
Her2 amplification, Rel-A, and Bach1 can influence APOBEC3A expression in breast cancer cells
PLOS Genetics
May 28, 2024
Madeline Dennis, Alyssa Hurley, Nicholas Bray, Cameron Cordero, Jose Ilagan, Tony M. Mertz, Steven A. Roberts
experiments, BT474 and MDA-MB-453 cells were treated with 2 μM of
Pacritinib
(
MedChemExpress
Catalog #
HY-16379
) or 2 μM of
Ruxolitinib
(
MedChemExpress
Catalog #
HY-50856
) for 16 hours and then harvested for RNA isolation.
qRT-PCR
Cells
(3)
Colorectal cancer-associated fibroblasts promote metastasis by up-regulating LRG1 through stromal IL-6/STAT3 signaling
Cell death & disease
December 20, 2021
Zhong B, Cheng B, Huang X, Xiao Q, Niu Z, Chen YF, Yu Q, Wang W, Wu XJ.
NovoProtein (catalog number: CC93-10μg). The
HO-3867
(catalog number:
HY-100453
),
Pacritinib
(catalog number:
HY-16379
),
Tocilizumab
(catalog number: HY-9917), SB431542(catalog number:
HY-10431
/CS-0135) were purchased from
(4)
Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways
Nature Communications
December 1, 2021
Sunwoo Oh et al.
#
S1149
), Chk1i (2 μM,
CCT244747
MedChemExpress
#
HY-18175
), JAKi #1 (2 μM
Pacritinib
,
MedChemExpress
#
HY-16379
), and JAKi #2 (2 μM
Ruxolitinib
,
MedChemExpress
#
HY-50856
). If not indicated otherwise, cells were treated
(5)
Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer
Nature communications
July 21, 2021
Wang W, Tang YA, Xiao Q, Lee WC, Cheng B, Niu Z, Oguz G, Feng M, Lee PL, Li B,
et al
.
(
MedChemExpress
, Cat#
HY-107425
),
dBET1
(
MedChemExpress
, Cat#
HY-101838
), and
Pacritinib
(
MedChemExpress
, Cat#
HY-16379
). Quantitative
coculture
assays
For the
cell viability assay
using direct cell–cell contact
coculture
,
(6)
Pacritinib (SB1518), a JAK2/FLT3 inhibitor for the treatment of acute myeloid leukemia
Blood cancer journal
November 1, 2011
Hart S, Goh KC, Novotny-Diermayr V, Tan YC, Madan B, Amalini C, Ong LC, Kheng B, Cheong A, Zhou J,
et al
.
(7)
SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies
Leukemia
November 1, 2011
Hart S, Goh KC, Novotny-Diermayr V, Hu CY, Hentze H, Tan YC, Madan B, Amalini C, Loh YK, Ong LC,
et al
.
(8)
Discovery of the macrocycle 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (SB1518), a potent Janus kinase 2/fms-like tyrosine kinase-3 (JAK2/FLT3) inhibitor for the treatment of myelofibrosis and lymphoma
Journal of medicinal chemistry
July 14, 2011
William AD, Lee AC, Blanchard S, Poulsen A, Teo EL, Nagaraj H, Tan E, Chen D, Williams M, Sun ET,
et al
.
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Pacritinib from MedChemExpress
Supplier Page
View Company Product Page
$77.00
Product Specs
Company Info
Citations
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