Recilisib from MedChemExpress

Product Specs
ItemRecilisib
CompanyMedChemExpress
Price $132.00Supplier Page View Company Product Page
Catalog NumberHY-101625
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.94%
TypeChemical
Molecular Weight336.79
FormulaC₁₆H₁₃ClO₄S
Research AreaCancer

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(1) Andrographolide alleviates type 2 diabetic nephropathy through suppressing PI3K/AKT1/RRM2-triggered oxeiptosisJournal of Advanced ResearchJuly 1, 2026Mingzheng Han, Jingchun Wang, Shuaihao Guo, Heyun Zhu, Lijiao Zhao, Ziqi Wu, Yijin Wu, Jianying Guo, Jianzhao Liao, Zhaoxin Tanginhibitor To activate or inhibit the PI3K/AKT1 signaling pathway, MDCK cells were treated with Recilisib (HY-101625, MCE, China) or Miltefosine (HY-13685, MCE, China), respectively. Moreover, Z-VAD-FMK (Z-VAD; HY-16658B,

(2) Camellia oil supplementation specifically enhances marbling scores via PI3K/Akt pathway while optimizing n-6/n-3 fatty acid ratios: A dual-benefit strategy for premium functional beef productionFood Chemistry: XMay 20, 2026Jin Ge Zhang, Jun Hao Cui, Ya Ting Fan, Xin Yue Yang, Cheng Xing Zhang, Ji Zhe Tan, Dong Qiao Peng, Yong Cheng Jininhibitor GSK2141795 (HY-15965, 10 mM/mL, MedChemExpress, China) and PI3K/Akt activators Recilisib (HY-101625 10 mM/mL, MedChemExpress, China) were diluted in DMSO (DMSO <0.15% in system) (Fan et al., 2024; Liu

(3) Loss of DLGAP5 impairs human and mouse oocyte maturation via disrupting the PI3K-AKT signaling axisJournal of Ovarian ResearchMay 13, 2026Meng Wang, Juepu Zhou, Youzhu Li, Zhou Li, Rui Long, Xiangfei Wang, Ruolin Mao, Lei Xu, Lei Cai, Bing Han, et al.interference, mice oocytes were blocked in M2 medium containing milrinone and the activators (Recilisib, HY-101625, MCE, China; 740 Y-P, HY-P0175, MCE, China) or the inhibitor (LY294002, HY-10108, MCE, China) for 12

(4) In Silico Prediction of EZHIP Post-Translational Modification Sites and Small-Molecule High-Throughput Screening for Quantitative EZHIP ModulationBrain Tumor Res TreatApril 30, 2026Jimin Moon, Jiwon Hwang, Chan Chung100 nM [19], AICAR (MCE, HY-13417); 500 µM [20], SC79 (MCE, HY-18749); 10 µM [21], Recilisib (MCE, HY-101625); 10 µM [22], Ionomycin (MCE, HY-13434); 1 µM [23], A23187 (MCE, HY-N6687); 1 µM [24], Spermine (MCE,

(5) Structural maintenance of chromosome protein 1A exacerbates liver fibrosis by enhancing hepatic stellate cell activation and extracellular matrix synthesis via laminin subunit gamma 2 activationJ Cell Commun SignalFebruary 23, 2026Dandan Wang, Ning Li, Ranyan Gao, Jiaxin Wang, Lingyi Xu, Fengchun Li, Xinyu Geng, Ram Prasad Chaulagain, Babalola Deborah Oluwaseun, Xiaoyu Zhang, et al.lentiviral particles via the tail vein (0.05 mL/mouse). 15 , 16 The PI3K/Akt agonist recilisib (10 mg/kg, HY‐101625, MedChemExpress) dissolved in DMSO was administered intraperitoneally once daily during the last 3 weeks

(6) Cyclovirobuxine D attenuates collagen-induced arthritis by inhibiting PI3K/AKT pathway and macrophage polarizationArthritis Research & TherapyJanuary 28, 2026Yaozong Sun, Jianhui Zhang, Yonghui Wu, Zhuo Liu, Guangrong Ligroup (n = 9), and the CIA + CycDH + Rec group (n = 9, treated with the PI3K activator Recilisib, MCE, HY-101625). The CIA model was induced as previously described. From post-immunization day 30 to day 60, mice in

(7) The swine acute diarrhea syndrome coronavirus spike protein promotes syncytial formation via upregulation of cellular cholesterol synthesismBioAugust 13, 2025Dakai Liu, Miaomiao Zeng, Jiyu Zhang, Liaoyuan Zhang, Hongyan Shi, Xin Zhang, Jialin Zhang, Jianfei Chen, Zhaoyang Ji, Xiuwen Li, et al.Santa Cruz Biotechnology (Shanghai, China). AICAR (HY-13417), AKT inhibitor VIII (HY-13055), Recilisib (HY-101625), LY294002 (HY-10108), Hoechst 33342 (R37605), and propidium iodide (PI, P4864) were purchased from

(8) Modified Qianghuo Shengshi Decoction Ameliorates Osteoarthritis via Inhibiting PI3K/Akt Pathway-Related FerroptosisJ Cell Mol MedJune 30, 2025Chen Zhuang, Enli Li, Wen-Kai Li, Xiaojuan Geng, Chenxuan Hong, Yu Pan, Lei YangIL‐1β (HY‐P70586), Ferrostatin‐1 (HY‐100579), Erastin (HY‐15763), LY294002 (HY‐10108) and Recilisib (HY‐101625) were obtained from MedChemexpress (USA). Primary antibodies targeting Col2 (ab34712), MMP13 (ab39012),

(9) Exploring the Therapeutic Potential of FSGTC for Osteoarthritis: A Comprehensive Study Combining Nested Case Analysis, Network Pharmacology, and Experimental ValidationDrug Des Devel TherJune 17, 2025Mingyu He, Jian Liu, Wu Gao, Yanqiu Sun, Xiaolu Chen, Yanyan FangCo., Ltd (Wuhan, China). PI3k/AKT inhibitor (LY294002, Cat.No.HY-10108) and agonist (Recilisib, Cat.No.HY-101625/CS-6712) were obtained from MedChemexpress (Shanghai, China).IL-1β (Cat.No.CG93) were obtained from

(10) Exploring the Therapeutic Potential of FSGTC for Osteoarthritis: A Comprehensive Study Combining Nested Case Analysis, Network Pharmacology, and Experimental ValidationDrug Des Devel TherJune 17, 2025Mingyu He, Jian Liu, Wu Gao, Yanqiu Sun, Xiaolu Chen, Yanyan FangCo., Ltd (Wuhan, China). PI3k/AKT inhibitor (LY294002, Cat.No.HY-10108) and agonist (Recilisib, Cat.No.HY-101625/CS-6712) were obtained from MedChemexpress (Shanghai, China).IL-1β (Cat.No.CG93) were obtained from

(11) Ac-HSP20 regulates autophagy and promotes the encystation of Acanthamoeba castellanii by inhibiting the PI3K/AKT/mTOR signaling pathwayParasites & VectorsAugust 19, 2024Siyao Guo, Di Liu, Xi Wan, Dingrui Guo, Meiyu Zheng, Wenyu Zheng, Xianmin Fengwere obtained from GenePharma (Shanghai, China). PI3K/mTOR Inhibitor-11 (HY-151622) and Recilisib (HY-101625) were purchased from MCE (NJ, USA). Acanthamoeba castellanii culture Acanthamoeba castellanii were

(12) The experimental study of mir‐99a‐5p negative regulation of TLR8 receptor mediated‐mediated innate immune response in rabbit knee cartilage injuryImmunity, Inflammation and DiseaseApril 11, 2024Jiebin Zhang, Ke Zheng, Yichao Wu, Shengting Zhang, Ao Guo, Cong Suiis involved in immune response, PI3K inhibitor (PI3K‐IN‐1, MCE HY‐12068) and agonist (Recilisib, MCE HY‐101625) were added in cell culture, respectively. After 12 h coculture, AKT and P65 showed synchronous changes

(13) ID2 promotes tumor progression and metastasis in thyroid cancerEndocrineJanuary 10, 2024Zhongming Deng, Min Xu, Zhenghua Ding, Jianqiao Kong, Juanjuan Liu, Zelin Zhang, Ping CaoChina). Thyroid cancer cells treated with Akt inhibitor MK-2206 (HY-108232) or Akt agonist Recilisib (HY-101625), which were purchased from MCE (Shanghai, China). After 48 h drug treatment, cell proteins were extracted.

(14) Inhibiting PI3K/Akt-Signaling Pathway Improves Neurobehavior Changes in Anti-NMDAR Encephalitis Mice by Ameliorating Blood-Brain Barrier Disruption and Neuronal DamageCellular and molecular neurobiologyOctober 1, 2023Gong Z, Lao D, Wu Y, Li T, Lv S, Mo X, Huang W.group were intraperitoneally administered LY294002 (HY-10108, PI3K inhibitor, 8 mg/kg) or Recilisib (HY-101625, PI3K agonist, 10 mg/kg) every day. LY294002 and Recilisib were from MedChemExpress, USA, and the above

(15) Ginsenoside Rk3 is a novel PI3K/AKT-targeting therapeutics agent that regulates autophagy and apoptosis in hepatocellular carcinomaJournal of Pharmaceutical AnalysisMay 1, 2023Linlin Qu, Yannan Liu, Jianjun Deng, Xiaoxuan Ma, Daidi Fan3-methyladenine (3-MA) (Cat. No. HY-19312), Z-VAD-fmk (Cat. No. HY-16658B), and recilisib (Cat. No. HY-101625) were bought from MedChemExpress (Princeton, NJ, USA). 2.2 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di-phenytetrazoliumromide

(16) Tumour necrosis factor‐α promotes BMHSC differentiation by increasing P2X7 receptor in oestrogen‐deficient osteoporosisJournal of Cellular and Molecular MedicineDecember 1, 2020Jiajia Lu, Zhibin Zhou, Jun Ma, Nan Lu, Zhu Lei, Di Du, Aimin Chendifferentiation‐related protein, NFATc1 (Figure 3D). Thirdly, when the PI3k/Akt signalling pathway was activated by HY101625 (MCE), the expression of P2X7 protein increased; on the contrary, when the signalling pathway was inhibited

(17) ON01210.Na (Ex-RAD®) mitigates radiation damage through activation of the AKT pathwayPloS oneJanuary 1, 2013Kang AD, Cosenza SC, Bonagura M, Manair M, Reddy MV, Reddy EP.

(18) Protein phosphorylation in Escherichia coli L. form NC-7Microbiology (Reading, England)December 1, 1998Freestone P, Grant S, Trinei M, Onoda T, Norris V.

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Recilisib from MedChemExpress

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Recilisib from MedChemExpress

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