Apilimod from MedChemExpress

Product Specs
ItemApilimod
CompanyMedChemExpress
Price $61.00Supplier Page View Company Product Page
Catalog NumberHY-14644
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.80%
TypeChemical
Molecular Weight418.49
FormulaC₂₃H₂₆N₆O₂
Research AreaInflammation/Immunology; Cancer

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(1) A PI(3,5)P2/CHMP4B axis on lysosomes is essential for microautophagic degradation of STINGNat CommunMay 27, 2026Tsumugi Shoji, Ayumi Shinojima, Takuma Kishimoto, Kanako Sato, Nana Ikegami, Eisuke Yumoto, Ruri Shindo, Yasunori Uchida, Satoshi Kusumi, Daisuke Koga, et al.Cayman), brefeldin A (11861, Cayman), Custom Kinase Screening Library (9003376, Cayman), apilimod (HY-14644, MCH MedChemExpress Co.), Vps34- IN1(17392, Cayman), E64d (4321, Peptide Institute), pepstatin A (4397,

(2) Targeting the ferritinophagy-lysosome axis as a therapeutic vulnerability in gastroenteropancreatic neuroendocrine tumorsCell Reports MedicineApril 21, 2026Yizhi Cao, Caleb Cheng, Yitong Yin, Sarah N. Yee, Yang Zheng, Somnath Mahapatra, Radha Paturu, Andrej Coleski, Shannon VanAken, Fan Yang, et al.S1413 Z-VAD-FMK,Selleck Chemicals,Cat# S7023 CAY10566,MedChemExpress,Cat# HY-15823 Apilimod,MedChemExpress,Cat# HY-14644 U18666A,MedChemExpress,Cat# HY-107433 Ferrostatin-1,MedChemExpress,Cat# HY-100579 D-luciferin Potassium

(3) Lysosomal swelling triggers LRRK2 activitybioRxivApril 3, 2026Tuyana Malankhanova, Zhiyong Liu, Samuel Strader, Weiping Wang, Kiwoon Sung, Zhong Li, Shawn M. Ferguson, Andrew B. Westall experiments, cells were exposed to the indicated compounds such as apilimod (100 nM, MCE, Cat# HY-14644), wortmannin (100 nM, MCE, Cat# HY-10197), GSK-A1 (100 nM, MCE, cat# HY-125118), bafilomycin (200 nM,

(4) How endosomal PIKfyve inhibition prevents viral membrane fusion and entrybioRxivNovember 28, 2025Nicholas Chow, Gustavo Scanavachi, Anand Saminathan, Tom Kirchhausentrafficking and fusion. MATERIAL AND METHODS Reagents The following reagents were used: apilimod (HY-14644, MedChemExpress), Bafilomycin A1 (B1793–2UG, Sigma-Aldrich), Milli-Q water (Z00QSV0US, MilliporeSigma),

(5) Tau seeding in neurons enabled by transient endolysosomal perforations are confined within endolysosomesbioRxivNovember 5, 2025Anwesha Sanyal, Gustavo Scanavachi, Elliott Somerville, Beren Aylan, Jose Inacio Costa-Filho, Forest Brooks, John R. Dickson, Bradley T. Hyman, Tom KirchhausenAssembly (NEB, E5520) according to the manufacturer’s instructions. Inhibitors Apilimod (MedChemExpress, HY-14644) and a protease/phosphatase inhibitor cocktail (Thermo Fisher Scientific, 78440) were used as indicated. Cells Human

(6) HSP90 deficiency promotes cholesteryl ester accumulation in lipid droplets via endocytosis of low-density lipoproteinCommun BiolAugust 6, 2025Chengxin Ma, Xinmeng Che, Yan Liang, Jiacheng Li, Kuan Yu, Tong-Jin Zhao, Peng Li, Feng-Jung Chenand VPS34-IN1 (Cat# S7980) were purchased from Selleck. PIK-FYVE inhibitor (also named apilimod, Cat# HY-14644) was purchased from MedChemExpress. Low density lipoprotein (LDL, human, Cat# GP23807) was purchased

(7) WNK1 mediates M-CSF-induced macropinocytosis to enforce macrophage lineage fidelityNat CommunMay 28, 2025Alissa J. Trzeciak, Zong-Lin Liu, Mohamed Gatie, Adam S. Krebs, Waleska Saitz Rojas, Anya J. O'Neal, Ann K. Baako, Zhaoquan Wang, Justin Nelson, Isabella C. Miranda, et al.indicated, Tocris, 1154-25- 2), LY294002 (50 μM, SelleckChem, S1105), or Apilimod (10 μM, MedChemExpress, HY-14644) were added 1 h prior to macropinocytosis induction. To quantify macropinocytosis via microscopy, Z-stacked

(8) Manganese is a potent inducer of lysosomal activity that inhibits de novo HBV infectionPLoS PathogJanuary 2, 2025Lin Yu, Hao Chang, Wentao Xie, Yuan Zheng, Le Yang, Qiong Wu, Fan Bu, Yuanfei Zhu, Youhua Xie, Guoyu Pan, et al.Tomatidine (HY-N2149), chloroquine (CQ, HY-17589A), Torin1 (HY-13003), PP242 (HY-10474), Apilimod (HY-14644), YM201636 (HY-13228), entecavir (HY-13623), FITC-Dextran (MV10000, HY-128868), LysoTracker (HY-D1300)

(9) CD40 Signaling in Mice Elicits a Broad Antiviral Response Early during Acute Infection with RNA VirusesVirusesJune 12, 2023Kai J. Rogers, Paige T. Richards, Zeb R. Zacharias, Laura L. Stunz, Rahul Vijay, Noah S. Butler, Kevin L. Legge, Gail A. Bishop, Wendy Maurydisruption of IL-12 production, the inhibitor apilimod (MedChemExpress, Monmouth Junction, NJ, USA, catalog #HY-14644) was administered via i.p. injection at a concentration of 2.5 mg/kg. The drug was administered on day

(10) Antibody-dependent enhancement (ADE) of SARS-CoV-2 pseudoviral infection requires FcγRIIB and virus-antibody complex with bivalent interactionCommunications biologyMarch 24, 2022Wang S, Wang J, Yu X, Jiang W, Chen S, Wang R, Wang M, Jiao S, Yang Y, Wang W, et al.Abcam ab120346; methyl-β-cyclodextrin, Sigma C4555-1G, Thioridazine, Sigma T9025-5G; Apilimod, MCE HY-14644; Cytochalasin D, MCE HY6682; Fillipin, CAYMAM CHEMICAM COMPANY 70400; Baf.A1,Cell Signaling 56545 S)

(11) A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activityBritish Journal of CancerAugust 18, 2020Eleftherios Kostaras et al.HY-14981), OSU-T315 (MedChemExpress, HY-18676), GSK2578215A (Cayman, 14603), apilimod (MedChemExpress, HY-14644), rapamycin (Selleckchem, S1039) and torin1 (Selleckchem, S2827) were diluted in dimethyl sulfoxide

(12) Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoVNature communicationsMarch 27, 2020Ou X, Liu Y, Lei X, Li P, Mi D, Ren L, Guo L, Guo R, Chen T, Hu J, et al.SID 26681509 (#HY-103353), Cathepsin B-specific inhibitor CA-074 (#HY-103350), PIKfyve inhibitors apilimod (#HY-14644) and YM201636 (#HY-13228), were purchased from Med Chem Express (MCE, New Jersey, USA). Calcium channel

(13) Therapeutic effect of the potent IL-12/IL-23 inhibitor STA-5326 on experimental autoimmune uveoretinitisArthritis research & therapyJanuary 1, 2008Keino H, Watanabe T, Sato Y, Niikura M, Wada Y, Okada AA.

(14) Selective abrogation of Th1 response by STA-5326, a potent IL-12/IL-23 inhibitorBloodFebruary 1, 2007Wada Y, Lu R, Zhou D, Chu J, Przewloka T, Zhang S, Li L, Wu Y, Qin J, Balasubramanyam V, et al.

(15) The role of the federal government in ensuring quality of care in long-term care facilitiesAnnals of health lawJanuary 1, 1997Hoffman DR.

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Apilimod from MedChemExpress

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Apilimod from MedChemExpress

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