Probenecid from MedChemExpress

Product Specs
ItemProbenecid
CompanyMedChemExpress
Price $61.00Supplier Page View Company Product Page
Catalog NumberHY-B0545
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.92%
TypeChemical
Molecular Weight285.36
Molecule NameProbenecid
FormulaC13H19NO4S
Research AreaMetabolic Disease; Cancer

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(1) Upregulation of TRPV2 exacerbates age-related hearing loss by promoting oxidative stress in spiral ganglion neuronsMolecular BrainMarch 6, 2026Zhidong Zhang, Huan Yin, Huan Cao, Miaomiao An, Yanan Li, Jianwang Yang, Tao Liu, Jiantao Wang, Lei Zhao, Chen Wang, et al.group receiving 100 mg/kg probenecid, a TRPV2 agonist. Probenecid (purchased from MCE, catalog number HY-B0545) was dissolved in a 5% sodium bicarbonate solution and administered via intraperitoneal injection three

(2) Lipid asymmetry disruption by XKR8 orchestrates neutrophil extracellular trap formation and inhibits fungal infectionNature ImmunologyMarch 4, 2026Weixiang Liu, Jieming Ping, Lishan Deng, Ke Wang, Jinnuo Xu, Ningxin Peng, Mengyun Yang, Hesen Tang, Zhengjie Liu, Wenliang Wang, et al.JNJ-28583113 (HY-149143), 9-phenanthrol (HY-108457), carvacrol (HY-N0711), GsMTx-4 (HY-P1410), probenecid (HY-B0545), GSK1016790A (HY-19608), GSK1702934A (HY-111098), bilirubin (HY-N0323), Yoda1 (HY-18723) and NTB (HY-101302)

(3) TENS alleviates CP/CPPS-related inflammation and pain by modulating Kir2.1-dependent macrophage polarizationFrontiers in ImmunologyJanuary 12, 2026Ting Hong, Xinyu Liu, Zepai Chi, Guoyuan Liu, Yuanfeng Zhang, Xuanhao Lin, Peixiu Yao, Qingyun Gong, Yonghai Zhang, Xuwei Hongzacopride (HY-103137, MCE, Monmouth Junction, USA), while the Pro group was treated with 2.5 μM probenecid (HY-B0545, MCE, Monmouth Junction, USA); both compounds were added 1 h post-ES and maintained for 16 h of incubation

(4) Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear MechanotransductionAdvanced ScienceDecember 22, 2025Yao Wen, Xinhui Zheng, Jieliu Li, Minyu He, Dongqi Fan, Xingyu Zhu, Qiming Zhai, Liangjing Xin, Tao ChenPharmacological treatments included: Cytochalasin D (MedChemExpress, HY‐N6682), Probenecid (MedChemExpress, HY‐B0545) and SKF‐96365 hydrochloride (MedChemExpress, HY‐100001). Treatments were administered 24 h prior to

(5) Uric Acid Functions as an Endogenous Modulator of Microglial Function and Amyloid Clearance in Alzheimer's DiseaseAdvanced ScienceOctober 6, 2025De Xie, Qiuyang Zheng, Jiaming Lv, Qian Zhang, Zhiwei Cui, Shuai Huang, Wei Yu, Binyang Chen, Wanling Que, Shanpan Fu, et al.Laboratory Animal Center guidelines. Chemicals and Reagents Uric acid (Sigma, U2625) and probenecid (MCE, HY‐B0545) were obtained from the respective suppliers. Aβ1‐42 peptide and FAM‐labeled Aβ1‐42 peptide were purchased

(6) Neuronal FGF13 Inhibits Mitochondria‐Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's DiseaseAdvanced ScienceMay 8, 2025Nanshan Song, Xiangxu Wang, Luqing Ha, Lamei Hu, Shuyuan Mei, Yue Liang, Yujie Zhao, Xingyin Yang, Qingyu Zhang, Yuanzhang Zhou, et al.(20 mg·kg−1 body weight, in saline, s.c.) plus a clearance inhibitor probenecid (MedChemExpress, Cat#HY‐B0545; 250 mg·kg−1 body weight, in dimethyl sulphoxide, i.p.) was administered every 3.5 days for five weeks.

(7) Gasdermin D deficiency aborts myeloid calcium influx to drive granulopoiesis in lupus nephritisCell Communication and SignalingJune 3, 2024Jiani Shen, Feng Li, Xu Han, Dongying Fu, Yiping Xu, Changjian Zhu, Zhou Liang, Ziwen Tang, Ruilin Zheng, Xinrong Hu, et al.incubated in PBS (calcium free) with Indo-1, AM (Invitrogen, Cat# I1223) (3 μM) and probenecid (MCE, Cat#HY-B0545) (2.5 μM) at 37°C, protected from light for 15 min. Then, the cells were centrifuged, washed with PBS

(8) Exogenous NADPH exerts a positive inotropic effect and enhances energy metabolism via SIRT3 in pathological cardiac hypertrophy and heart failureeBioMedicineDecember 1, 2023Ke Qian, Jie Tang, Yue-Juan Ling, Ming Zhou, Xin-Xin Yan, Yu Xie, Lu-Jia Zhu, Koju Nirmala, Kang-Yun Sun, Zheng-Hong Qin, et al.channel blocker, 0.1 μM),24 or 3-TYP (Selleck S8628, a SIRT3 inhibitor, 68 μM),25 or probenecid (MCE HY-B0545, 200 μM) and carbenoxolone (MCE, HY-B1588S, both Pannexin-1 antagonists, 10 μM),26 or SQ22536 (AdooQ,

(9) An imbalance of netrin‐1 and DCC during nigral degeneration in experimental models and patients with Parkinson's diseaseCNS Neuroscience & TherapeuticsJuly 1, 2023Ye Hua, Wenjing Han, Linfeng Zhou, Jing Gao, Jifeng Zhao, Nanshan Song, Bin Hu, Qingyu Yao, Yumin Liu, Deen Xu, et al.Figure S2D, MPTP (25 mg/kg body weight, in saline, s.c.) and a clearance inhibitor probenecid (Cat#HY‐B0545, MedChemExpress, Shanghai, China; 250 mg/kg body weight, in saline, i.p.) was administered twice a week

(10) GRP75-faciliated Mitochondria-associated ER Membrane (MAM) Integrity controls Cisplatin-resistance in Ovarian Cancer PatientsInternational journal of biological sciencesJanuary 1, 2022Li J, Qi F, Su H, Zhang C, Zhang Q, Chen Y, Chen P, Su L, Chen Y, Yang Y, et al.species) Green Kit (#22900) and MitoROS™ 580 kit (#22971) were obtained from AAT Bioquest. Probenecid (HY-B0545) was obtained from MCE. The Duolink® In situ Red Starter Kit (DUO92101) and the remaining fine-grade

(11) Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulationJournal of molecular and cellular cardiologyJuly 1, 2012Koch SE, Gao X, Haar L, Jiang M, Lasko VM, Robbins N, Cai W, Brokamp C, Varma P, Tranter M, et al.

(12) Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicinPloS oneJanuary 1, 2011Greene TA, Alarcon S, Thomas A, Berdougo E, Doranz BJ, Breslin PA, Rucker JB.

(13) Probenecid, a gout remedy, inhibits pannexin 1 channelsAmerican journal of physiology. Cell physiologySeptember 1, 2008Silverman W, Locovei S, Dahl G.

(14) Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anionsMolecular pharmacologyApril 1, 2000Bakos E, Evers R, Sinkó E, Váradi A, Borst P, Sarkadi B.

(15) [Serum sickness with pseudolymphomatous lymph node hyperplasia caused by salicylazosulfapyridine]L'union medicale du CanadaApril 1, 1975Delage C, Lagacé R.

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Probenecid from MedChemExpress

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Probenecid from MedChemExpress

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