NAD+ from MedChemExpress

Product Specs
ItemNAD+
CompanyMedChemExpress
Price $55.00Supplier Page View Company Product Page
Catalog NumberHY-B0445
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.96%
TypeChemical
Molecular Weight663.43
FormulaC₂₁H₂₇N₇O₁₄P₂
Research AreaMetabolic Disease

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(1) Inhalable ROS-Responsive Nanospray Activates PPAR-γ to Restore Macrophage Mitochondrial Homeostasis and Attenuate Radiation-Induced Lung InjuryAdv Sci (Weinh)July 8, 2026Mingquan Gao, Xudong Yu, Ziqian Shang, Mengyao Tan, Xie Huang, Zaizhi Du, Xiaojiao Wang, Xinrui Yang, Ximei Luo, Weidong Wang, et al.1,3,5‐trimethylbenzene (TMB) was procured from Adamas‐Beta (Shanghai, China). Nicotinamide adenine dinucleotide (NAD+, HY‐B0445) and Indocyanine Green (ICG, HY‐D0711) were sourced from MedChemExpress (Princeton, NJ, USA). NH2‐PEG‐COOH

(2) Metabolically engineered probiotic OMVs as nanovaccine mediating sequential immunomodulation for chronic bone infection immunotherapyCell Rep MedJune 16, 2026Jie Lei, Bide Tong, Shihao Zhang, Zixuan Ou, Dingchao Zhu, Xingyu Zhou, Huaizhen Liang, Zhengdong Zhang, Lei Tan, Cao Yang, et al.Z03300 "LPS, <3% Protein (Lowry)",Sigma-Aldrich,Cat. No: L6529-1MG "NAD+, 99.96%",MedChemExpress,Cat. No: HY-B0445 "NMN, 99.94%",MedChemExpress,Cat. No: HY-F0004 "NR, 99.90%",MedChemExpress,Cat. No: HY-123033A "ATP,

(3) Dual Pathways of UBE4B Inhibit Apoptosis in p53-Positive Tumor Cells via CCAR2 DegradationInt J Mol SciApril 21, 2026Bo Jin, Junyao Qu, Peng Xu, Bo Zhao, Xianting Jiaoh. Reagents: etoposide (MCE, Monmouth Junction, NJ, USA, HY-13629), CHX (MCE, HY-12320), NAD+ (MCE, HY-B0445). 4.2. Cell Transfection H125 cells and H1299 cells were transfected with Lipofectamine™ 3000 (Invitrogen,

(4) Notch Signaling Exacerbates Pulmonary Fibrosis by Regulating the Differentiation of CD4+ Tissue-Resident Memory T CellsBiomoleculesFebruary 20, 2026Jia Shi, Ruiting Su, Lili Zhuang, Zhangmei Lin, Xinyuan Ruan, Yichao Qian, Jieying Zhu, Shuyi Wang, Niansheng Yangorder to evaluate the contribution of TRM cells to PF, NAD+ (MCE, Monmouth Junction, NJ, USA, Cat#: HY-B0445, 60 mg/mouse) or PBS was delivered through tail vein injection beginning one day prior to BLM administration,

(5) H3K18 lactylation-mediated SPHK1-SIRT1 feedback loop accelerates pyroptosis of tubular epithelial cells in sepsis-associated acute kidney injuryTheranosticsFebruary 18, 2026Yan Huang, Eryang Zhao, Guangyu Zhao, Wenfeng Zhuo, Yingsong Zhao, Hongda Wang, Guozheng Lv, Rong Hu, Zhu Zeng, Shengbo Han, et al.10 mg/kg), Sanguinarine (MCE, HY-N0052, 10 mg/kg), Quercetin (MCE, HY-18085, 50 mg/kg), NAD+ (MCE, HY-B0445, 100 mg/kg), EX-527 (Selleck, S1541, 10 mg/kg), and Resveratrol (Selleck, S1396, 50 mg/kg). At indicated

(6) Nicotinamide adenine dinucleotide inhibits the production of reactive oxygen species and myocardial cell pyroptosis caused by hypoxia/re-oxygenation injuryWorld Journal of CardiologyJanuary 26, 2026Shuang Dong, Yun-Qi Liu, Yi-Jun Tu, Shan Gao, Yu-Jie Liu, Chang Liu, Zuo-Wei Peichemicals were purchased from Sigma-Aldrich (MO, United States), unless otherwise specified. NAD+ (HY-B0445, MedChemExpress, NJ, United States) was dissolved in phosphate-buffered solution (PBS; KeyGEN BioTECH,

(7) FOXO1-NMNAT3 axis dysregulation promotes doxorubicin cardiotoxicity: NAD + replenishment as a redox-targeted antioxidant therapyRedox ReportDecember 31, 2025Fang Cheng, Minzhu Zhao, Qi Wang, Hongli Xiong, Kai Yu, Chong Chen, Ying Zhu, Yemiao Chen, Jianbo LiPart 2: Mice were divided into six groups (n = 5/group): (a) control group; (b) DOX group; (c) NAD+ (#HY-B0445, MedChemExpress, Monmouth Junction, NJ, USA) group; (d) NAD++DOX group; (e) nicotinamide mononucleotide

(8) Synthesis and Biological Evaluation of a Caffeic Acid Phenethyl Ester Derivatives as Anti-Hepatocellular Carcinoma Agents via Inhibition of Mitochondrial Respiration and Disruption of Cellular MetabolismCancers (Basel)December 27, 2025Hao Dong, Yuan Gao, Dongyue Jiang, Chenjie Feng, Xinyue Gu, Xiyunyi Cai, Yulin Liu, Guangyu Zhang, Jiacheng Wen, Weiwei Diao, et al.D303893-100mg), Mdivi-1 (MCE, HY-15886), nicotinic acid (Yuanye, Shanghai, China, S13023), NAD+ (MCE, HY-B0445), succinic acid (Psaitong.Inc., China, S10107), malic acid (Psaitong.Inc., China, M70012),were obtained

(9) High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE ‑/‑ mice via the NAD + ‑mediated SIRT1/MFN2 pathwayMolecular Medicine ReportsNovember 18, 2025Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Peiserum-free medium. Subsequently, NAD+ solutions at varying concentrations (0, 1, 5, 7 and 10 mM) (cat. no. HY-B0445; MedChemExpress) were added to the wells, and the cells were incubated for 48 h in a humidified cell

(10) PARP3 promotes macrophage inflammation via mono ADP ribosylation of Ppia Glu140Mol MedJune 3, 2025Runjie Fan, Rongxing Zhu, Xiangxiu Cao, Shuhui Ye, Fengyi Gao, Yue Wu, Wanxin Yao, Guang Liang, Yanmei ZhangReagent was purchased from Millipore (Cat. #MABE1076), β-nicotinamide adenine dinucleotide (NAD+, Cat. #HY-B0445) was purchased from MCE, Escoli receptor DH5α&BL21(DE3) was purchased from Accurate Biology, and His

(11) Protocol for high-throughput screening of SIRT7 inhibitors using fluorescent peptide technologySTAR ProtocolsJune 1, 2025Tian-Shu Kang, Xiaopeng Lu, Jinke Gu, Yuan Tian, Wei-Guo Zhupeptides, and recombinant proteins","Chemicals, peptides, and recombinant proteins" ,, NAD+,MCE,Cat#HY-B0445 NAM,Beyotime,Cat#S1761 Kanamycin,Solarbio,Cat#K8020 PageRuler prestained protein ladder,Thermo Fisher Scientific

(12) BACH1 deficiency improves placental angiogenesis via SLC25A51-mediated mitochondrial NAD+ transport in intrahepatic cholestasis of pregnancyMol MedMay 1, 2025Shengpeng Li, Weiying Zhu, Zhixuan Xing, Dan Chen, Huimin Zhao, Yanli Zhang, Wenlong Zhang, Jiaojiao Sun, Yaxian Wu, Ling Ai, et al.NextGen-O2k) containing 5 mM malate (T2S0850, TargetMol), 10 mM pyruvate (T4804, TargetMol), and 1 mM NAD+ (HY-B0445, MCE). The reaction mixture was agitated at 900 rpm, and the tube was briefly opened every 10 min to

(13) UGDH Lactylation Aggravates Osteoarthritis by Suppressing Glycosaminoglycan Synthesis and Orchestrating Nucleocytoplasmic Transport to Activate MAPK SignalingAdvanced science (Weinheim, Baden-Wurttemberg, Germany)May 1, 2025Lan W, Chen X, Yu H, Ruan J, Kang J, Nie X, Cao Y, Tang S, Ding C.incorporating 40 µg UGDH from CoIP, 1 mm UDP‐Glc (QiYue BIO,117756‐22‐6), and 10 mm NAD+ (MedChemExpress, HY‐B0445) as essential components, for a duration of 1 min at room temperature. After the incubation, the production

(14) Nudix Hydrolase 13 Impairs the Initiation of Colorectal Cancer by Inhibiting PKM1 ADP‐RibosylationAdvanced ScienceFebruary 8, 2025Jinlong Lin, Yixin Yin, Jinghua Cao, Bingxu Zou, Kai Han, Yufan Chen, Siyu Li, Cijun Huang, Jiewei Chen, Yongrui Lv, et al.H2A, or H2B (1 µg) was mixed with 1 µg recombinant human PARP1 (Sino Biological) with or without NAD+ (HY‐B0445, MCE, China) in 1×reaction buffer (50 mm Tris‐HCl (pH 8.0), 4 mm MgCl2, 2 0mm NaCl, 1 mm DTT, and 100

(15) Identifying compound-protein interactions with knowledge graph embedding of perturbation transcriptomicsCell GenomOctober 9, 2024Ni S, Kong X, Zhang Y, Chen Z, Wang Z, Fu Z, Huo R, Tong X, Qu N, Wu X, et al.(NSK-98),MedChemExpress,HY-B0494; CAS: 2438-72-4 IGUANA-1,MedChemExpress,HY-148466; CAS: 2756014-25-0 NAD+,MedChemExpress,HY-B0445; CAS: 53-84-9 His-ALDH1B1,This paper,N/A ,, Deposited data,Deposited data,Deposited data ,, Protein-related

(16) YZL-51N functions as a selective inhibitor of SIRT7 by NAD(+) competition to impede DNA damage repairiScienceJune 21, 2024Kang TS, Yan YM, Tian Y, Zhang J, Zhang M, Shu Y, Huang J, He J, Tao CT, Zhu Q, et al.Bio,Cat#FSP500 Trypsin,Macgene,Cat#K2708200 Penicillin/Streptomycin,Macgene,Cat#J3112200 4% Paraformaldehyde Fix Solution,DING GUO PROSPEROUS,Cat#AR-0211 NAD+,MCE,Cat#HY-B0445 NAM,Beyotime,Cat#S1761 Recombinant H3K18 acetylated peptides,AnaSpec,Cat#AS-64638-1 Triton X-100,Solarbio,Cat#T8200 PVDF

(17) Tubular insulin-induced gene 1 deficiency promotes NAD+ consumption and exacerbates kidney fibrosisEMBO Molecular MedicineMay 28, 2024Shumin Li, Jun Qin, Yingying Zhao, Jiali Wang, Songming Huang, Xiaowen Yumethods were used to assess a compound’s ability to inhibit hAldh1a1: 100–200 nM enzyme, 500 μM NAD+ (HY-B0445, MCE), 10 μM compounds, and 400 μM propionaldehyde in 20 mM Tris-HCl, pH = 7.5 at 25 °C. Fluorescence

(18) TREM2 macrophage promotes cardiac repair in myocardial infarction by reprogramming metabolism via SLC25A53Cell Death & DifferentiationFebruary 1, 2024Shiyu Gong, Ming Zhai, Jiayun Shi, Guanye Yu, Zhijun Lei, Yefei Shi, Yanxi Zeng, Peinan Ju, Na Yang, Zhuo Zhang, et al.containing 5 mM malate (T2S0850, TargetMol) and 10 mM pyruvate (T4804, TargetMol) along with 1 mM NAD+ (HY-B0445, MCE). The reaction was agitated at 900 rpm and the tube was briefly opened every 10 min to allow for

(19) Role of PARP-1 in Human Cytomegalovirus Infection and Functional Partners Encoded by This VirusVirusesSeptember 15, 2022Zhang W, Guo J, Chen Q.in water used at a final concentration of 250 μg/mL. Nicotinamide adenine dinucleotide (NAD+) (MCE, HY-B0445) was dissolved in water. 2.3. Oligonucleotides and Plasmid Construction The primers used for plasmid

(20) Functional assessment of the cell-autonomous role of NADase CD38 in regulating CD8(+) T cell exhaustioniScienceMay 20, 2022Ma K, Sun L, Shen M, Zhang X, Xiao Z, Wang J, Liu X, Jiang K, Xiao-Feng Qin F, Guo F, et al.PerfectStart Green qPCR SuperMix,TransGen Bitoech,Cat# AQ601-04 NMN,Yeasen Biotechnology,Cat# 60303ES80 NAD+,MCE,Cat# HY-B0445 Ficoll-Paque,GE,Cat# 17-1440-03 Percoll,Cytiva,Cat# 17089109 OVA peptides,Abcepta Biotech,N/A Human

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NAD+ from MedChemExpress

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