Linaprazan from MedChemExpress | Biocompare.com

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Linaprazan

Description

Linaprazan (AZD0865) can inhibit H+,K+ -ATPase in the stomach through K+ competitive binding, (IC₅₀: 1.0 ± 0.2 µM), it has a strong inhibitory effect on acid. Linaprazan (AZD0865) can be used for research on reflux esophagitis with oral activity

Product Specs
ItemLinaprazan
CompanyMedChemExpress
Price $99.00Supplier Page View Company Product Page
Catalog NumberHY-100412
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity98.80%
TypeChemical
Molecular Weight366.46
FormulaC₂₁H₂₆N₄O₂
Research AreaCancer

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(1) Enhancer demethylation-regulated gene score identified molecular subtypes, inspiring immunotherapy or CDK4/6 inhibitor therapy in oesophageal squamous cell carcinomaeBioMedicineJuly 1, 2024Wenyan Gao, Shi Liu, Yenan Wu, Wenqing Wei, Qi Yang, Wenxin Li, Hongyan Chen, Aiping Luo, Yanfeng Wang, Zhihua LiuGGACCAGCAGATTCAGAACGG. β-actin-F: CTGGAACGGTGAAGGTGACA; β-actin-R: AAGGGACTTCCTGTAACAATGCA. For CPI-455 (HY100412; MedChemExpress, NJ, USA) and 5-AzaC (HY10586, MedChemExpress, NJ, USA) treatment, after seeding KYSE450

(2) Absorption, distribution, metabolism and excretion of linaprazan glurate in ratsJournal of pharmaceutical and biomedical analysisMay 15, 2024Zhang X, Liu D, Lu M, Yuan Y, Yang C, Yang Y, Xiu J, Hu P, Zheng Y, Diao X.

(3) A randomized, comparative study of three doses of AZD0865 and esomeprazole for healing of reflux esophagitisClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological AssociationDecember 1, 2007Kahrilas PJ, Dent J, Lauritsen K, Malfertheiner P, Denison H, Franzén S, Hasselgren G.

(4) Mechanism of action of AZD0865, a K+-competitive inhibitor of gastric H+,K+-ATPaseBiochemical pharmacologyJanuary 15, 2007Gedda K, Briving C, Svensson K, Maxvall I, Andersson K.

(5) [The correct formulation of clinical questions for the practice of evidence based medicine]Acta medica portuguesaAugust 1, 1998Carneiro AV.

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