PLX5622 from MedChemExpress

Product Specs
ItemPLX5622
CompanyMedChemExpress
Price $104.00Supplier Page View Company Product Page
Catalog NumberHY-114153
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.95%
TypeChemical
Molecular Weight395.41
FormulaC₂₁H₁₉F₂N₅O
Research AreaNeurological Disease

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(1) Viral Microglia Reprogramming Clears Oligomeric Neurotoxic DebrisbioRxivApril 8, 2026Griffin P. Carter, Zachary P. McKay, Mark A. Katz, Lisbeth Disla, Dasean T. Nardone-White, Derek Southwell, Michael C. Brown, Matthias Gromeierdiet was prepared to contain 1200 ppm Plx5622 (600mg Plx5622 per 500g chow). Plx5622 (MedChemExpress, #HY-114153) was dissolved in 3.6 ml anhydrous DMSO (Sigma-Aldrich, #276855–100ML) by gentle mixing with occasional

(2) Oligodendrocyte precursor cells-microglia crosstalk via BMP4 drives microglial neuroprotective response and mitigates Alzheimer's diseaseSignal Transduct Target TherMarch 25, 2026Soonbong Baek, Jaemyung Jang, Seungeun Yeo, Hyun Jin Jung, Youngshik Choeinduce microglial depletion, 2-month-old 5xFAD mice received i.p. injections of PLX5622 (MedChemExpress, HY-114153) at a dose of 100 mg/kg body weight every other day for a total of five treatments. Two days after the

(3) Astrocytic EAAT1 suppression by EV-ACLY underlies glutamate imbalance and cognitive impairment in POCDCommunications BiologyMarch 19, 2026Zheng Qi, Lan Ding, Yingying Zhao, Gezi Chen, Bin Cao, Yu Su, Qinghe Xing, Jian-Jun Yangmicroglia, 20-month-old male C57BL/6 mice were fed ad libitum with a chow diet containing 1200 ppm PLX5622 (#HY-114153, MedChemExpress, USA;) for 7 consecutive days. Control mice received an identical diet without PLX5622.

(4) Microglia replacement by peripheral delivery of CSF1R inhibitor-resistant hematopoietic cellsMolecular TherapyFebruary 4, 2026Sonia I. Lombroso, Emily I. Church, Ryan N. Anderson, Carleigh A. O’Brien, Yixuan Zhu, Asif A. Dar, Freddy S. Purnell, Eli M. Levitt, Brian Temsamrit, Fazeela Yaqoob, et al.C57BL/6-Tg(CAG-EGFP)131Osb/LeySopJ mice (The Jackson Laboratory, strain 006567). Compounds and diet PLX3397 (HY-16749), PLX5622 (HY-114153), and BLZ945 (sotuletinib, HY-12768) were obtained from MedChemExpress or Selleckchem and used in vitro

(5) BTLA-mediated regulation of neuroimmune responses enhances recovery after intracerebral hemorrhageJournal of NeuroinflammationJanuary 23, 2026Yuxing Wu, Yanping Zhang, Peiji Fu, Maosen Huang, Shuai Chen, Yi Li, Tao Wu, Yousef Rastegar-Kashkooli, Nannan Cheng, Taiqi Zhao, et al.containing the CSF1R inhibitor PLX5622 (PLX5622 formulated in AIN-76 A standard chow at 1200 ppm, MCE, HY-114153 C) for 14 days before ICH induction [32, 33]. As previously shown, the anti-BTLA agonist antibody (15.4

(6) Microglial epigenetic memory is associated with accelerated resolution of inflammatory pain induced by prophylactic macrophage-derived small extracellular vesiclesbioRxivJanuary 22, 2026Xuan Luo, Jason R. Wickman, Jason T. DaCunza, Yuzhen Tian, Ahmet Sacan, Seena K. AjitLaboratory. To pharmacologically ablate microglia in the spinal cord, a CSF1R inhibitor, PLX5622 (#HY-114153, MedChemExpress, Monmouth Junction, NJ), was formulated in AIN-76A chow containing 1,200 parts per million

(7) Erythrocyte-microglia crosstalk contributing to sex differences in pediatric brain tumorigenesisResearch SquareJanuary 20, 2026Baoli Huinduced with tamoxifen at P7 as previously described73. For mouse treatment, PLX5622 (MEDCHEMEXPRESS LLC, HY-114153) was delivered at a dose of 45 mg/kg body weight through oral gavage into the stomach of the pregnant

(8) Microglia interact with dendritic spines and regulate spine numbers after brain injury following resuscitation from a cardiac arrestExperimental NeurologyOctober 1, 2025Jacob M. Basak, Macy Falk, Andra L. Dingman, Annabelle Moore, Erika Tiemeier, Giulia Aimale, Nidia Quillinanwere used in the experiments. 2.3. PLX5622 preparation and animal treatment PLX5622 (MedChemExpress, HY-114153) was dissolved in dimethyl sulfoxide (DMSO) to make a stock concentration of 100 mg/ml and stored at

(9) Orlistat Confers Neuroprotection in Traumatic Brain Injury by Modulating Microglial Lipid MetabolismCellsSeptember 19, 2025Chenxuan Yu, Yu Ni, Yuxuan Xiong, Huayu Kang, Zhengqiao Jiang, Yuan Liu, Xincheng Zhang, Yanchao Liu, Kai Zhao, Sheng Wang, et al.creation, and it continued after model creation until sacrifice. 5.3. Microglia Clearance PLX5622(HY-114153, MCE, China) was dissolved in DMSO and diluted with PBS to the final dose concentration. Starting from

(10) Involvement of Microglia in Retinal Ganglion Cell Injury Induced by IOP Elevation in a Rat Ex Vivo Acute Glaucoma ModelBiomedicinesJuly 8, 2025Sato T, Ishikawa M, Izumi Y, Shibata N, Sato K, Ohno-Oishi M, Tawarayama H, Kunikata H, Zorumski CF, Nakazawa T.TAK-242 (Cat#13871, Cayman Chemical, Ann Arbor, MI, USA) (1 μM), or a CSF-1R inhibitor, PLX5622 (Cat#HY-114153, MedChemExpress, Monmouth Junction, NJ, USA) (10 μM or 20 μM), was administered in aCSF at the time

(11) Delayed microglial depletion protects against white matter injury following neonatal cerebral hemorrhage in miceNeural Regen ResJuly 5, 2025Xiaoxiao Jing, Xiaoli Zhang, Hongwei Li, Yu Yang, Zuhang Zhao, Yuandan Li, Jinjin Zhu, Yiran Xu, Jing Yuan, Tiantian He, et al.power. PLX5622 administration The CSF1R inhibitor PLX5622 (MedChemExpress, Monmouth Junction, NJ, USA, HY-114153) was dissolved in dimethyl sulfoxide (Meilunbio, Dalian, China, Cat# J0604A) to create a 100 mg/mL stock

(12) Exploitable mechanisms of antibody and CAR mediated macrophage cytotoxicityNat CommunJuly 1, 2025Tianyi Liu, Meng Zhang, Tatyanah Farsh, Haolong Li, Audrey Kishishita, Abhilash Barpanda, Stanley G. Leung, Jun Zhu, Hyuncheol Jung, Junjie Tony Hua, et al.inhibitor treated mice, mice were fed with a diet containing the CSF1R inhibitor PLX5622 (MedChemExpress, HY-114153) at a concentration of 1200 ppm, which corresponds to an estimated mean plasma concentration of 9090

(13) Immunotherapy-related cognitive impairment after CAR T cell therapy in miceCellJune 12, 2025Anna C. Geraghty, Lehi Acosta-Alvarez, Maria C. Rotiroti, Selena Dutton, Michael R. O’Dea, Wonju Kim, Vrunda Trivedi, Rebecca Mancusi, Kiarash Shamardani, Karen Malacon, et al.assays and CSF and brain collection as described below. PLX5622 was purchased from MedChemExpress (HY-114153) and formulated in AIN-76A standard chow by Research Diets Inc (D19101002i). CCL11 antibody and CCR3

(14) Mast cell promotes obesity by activating microglia in hypothalamusFront Endocrinol (Lausanne)March 21, 2025Wen Tian, Jinghui Wang, Yangyang Zhu, Yi Zhang, Liwei Chen, Cheng HuFood intake and body weight were measured. To eliminate microglia, mice were received PLX5622(MCE, HY-114153) in drink water at 90 mg/kg once a day for 7 consecutive days. 4.5 Immunofluorescence For immunofluorescence,

(15) Intratumoral delivery of lipid nanoparticle-formulated mRNA encoding IL-21, IL-7, and 4-1BBL induces systemic anti-tumor immunityNature CommunicationsDecember 6, 2024Ahmed E. I. Hamouda, Jessica Filtjens, Elisabeth Brabants, Daliya Kancheva, Ayla Debraekeleer, Jan Brughmans, Lotte Jacobs, Pauline M. R. Bardet, Elisabeth Knetemann, Pierre Lefesvre, et al.18.5, BioXCell) intraperitonially 24 h later. For macrophage depletion, the CSF1R inhibitor PLX5622 (HY-114153, MedChemExpress) was administered via rodent chow (1200 mg PLX5622/Kg chow) starting 2 days prior to

(16) Microglia synchronizes with the circadian rhythm of the glymphatic system and modulates glymphatic system functionIUBMB LifeDecember 1, 2024Ting Yang, Yan Tang, Xinghua Liu, Song Gong, Ensheng Yao100 μg/kg. DCZ was administered 50 min before the infusion of the tracer. PLX5622 (MedChemExpress, HY‐114153), prepared as a stock solution with 50 mg/mL in DMSO, was stored at −20°C. PLX5622 (50 mg/kg) was intraperitoneally

(17) Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolismNeuronSeptember 4, 2024Caterina P. Profaci, Sean S. Harvey, Kaja Bajc, Tony Z. Zhang, Danielle A. Jeffrey, Alexander Z. Zhang, Kelsey M. Nemec, Hayk Davtyan, Carleigh A. O’Brien, Gabriel L. McKinsey, et al.I8015 Trizol,Invitrogen,Cat. # 15596026 PLX5622,"PLEXXIKON, Inc.",NA PLX5622,MedChemExpress,Cat. # HY-114153 AIN-76A Rodent Diet (irradiated),"Research Diets, Inc.",Cat. # D10001i "AIN-76A Rodent Diet with 1200mg/kg

(18) Microglia contribute to methamphetamine reinforcement and reflect persistent transcriptional and morphological adaptations to the drugBrain, behavior, and immunityAugust 1, 2024Vilca SJ, Margetts AV, Höglund L, Fleites I, Bystrom LL, Pollock TA, Bourgain-Guglielmetti F, Wahlestedt C, Tuesta LM.saline. 2.3. Microglial depletion To deplete microglia during METH IVSA, CSF1R inhibitor PLX5622 (HY-114153, MedChemExpress, NJ, USA) was formulated in AIN-76A chow (1200 ppm; Research Diets, New Brunswick, NJ,

(19) TREM2 alleviates white matter injury after traumatic brain injury in mice might be mediated by regulation of DHCR24/LXR pathway in microgliaClinical and Translational MedicineApril 22, 2024Zhao Li, Shenghui Yu, Lin Li, Chao Zhou, Lin Wang, Shuang Tang, Nina Gu, Zhaosi Zhang, Zhijian Huang, Hong Chen, et al.body weight and the COG1410 was dissolved in lactated Ringer's solution. In addition, 1200 ppm PLX5622 (#HY‐114153, MedChemExpress) was added to AIN‐76A standard chow to deplete microglia, and the chow was administrated

(20) Chimeric antigen receptor macrophages target and resorb amyloid plaquesJCI insightFebruary 6, 2024Kim AB, Xiao Q, Yan P, Pan Q, Pandey G, Grathwohl S, Gonzales E, Xu I, Cho Y, Haecker H, et al.months of age, were preconditioned with either 20 mg/kg Busulfan once a day for 2 days or PLX5622 (HY-114153, MedChemExpress) at 50 mg/kg twice daily for 4–7 days by i.p. injection. Busulfan was dissolved in DMSO

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PLX5622 from MedChemExpress

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PLX5622 from MedChemExpress

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