AF38469 from MedChemExpress

Product Specs
ItemAF38469
CompanyMedChemExpress
Price $253.00Supplier Page View Company Product Page
Catalog NumberHY-12802
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.28%
TypeChemical
Molecular Weight324.25
FormulaC₁₅H₁₁F₃N₂O₃
Research AreaNeurological Disease

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(1) Targeting p75NTR activity alleviates the neurotoxic effect of high glucose on iPSC-derived dopaminergic neuronsStem Cell Research & TherapyMarch 21, 2026Konstantina Chanoumidou, Ioanna Zota, Maria Anna Papadopoulou, Chrystalla Konstantinou, Alexandros Tsimpolis, Electra Tsagliotis, Maria Tziortziou, Katerina Ntarntani, Anne Grünewald, Matthieu David Lavigne, et al.HY-117088) for 48 h. For sortilin inhibition, neurons were treated with 1 µM AF38469 (MedChemExpress, HY-12802) for 48 h. Amyloid-β treatment The Amyloid-β (1–42) peptide was purchased from AnaSpec (AS-20276,

(2) Molecular recognition of thyroglobulin by sortilinNature CommunicationsJanuary 24, 2026Irene Boniardi, Giorgia Tanzi, Alessio Di Ianni, Andrea Graziadei, Marko Nedeljković, Camilla Stejskalova, Francesca Cosciacomplex was then perturbated with the addition of NT (MedChemExpress), AF38469 (AF) (Medchemexpress; HY-12802) or TGpep to a final concentration in solution of 30 µM for NT and AF38469 and 1 mM for TGpep (a titration

(3) Microglial progranulin differently regulates hypothalamic lysosomal function in lean and obese conditions via cleavage-dependent mechanismsJ NeuroinflammationMarch 7, 2025Chae Beom Park, Chan Hee Lee, Gil Myoung Kang, Se Hee Min, Min-Seon KimPGRN, PGRN fragments (100 ng each), FITC-PGRN + sortilin inhibitor AF38469 (3 µg, MedchemExpress, #HY12802), and LysoTracker (1:2000) were then applied to the N1 cells on ice for 30 min and allowed to internalize

(4) Sortilin-mediated translocation of mitochondrial ACSL1 impairs adipocyte thermogenesis and energy expenditure in male miceNature CommunicationsSeptember 5, 2024Min Yang, Jing Ge, Yu-Lian Liu, Huan-Yu Wang, Zhi-Han Wang, Dan-Pei Li, Rui He, Yu-Yu Xie, Hong-Yan Deng, Xue-Min Peng, et al.to generate HFD-induced obesity mice. For sortilin inhibition studies, mice were given AF38469 (no. HY-12802, MCE) 5-10 μg/day/mouse in their drinking water as previous described40. In general, AF38469 was dissolved

(5) The Membrane Protein Sortilin Is a Potential Biomarker and Target for GlioblastomaCancers (Basel)April 27, 2023Mark Marsland, Amiee Dowdell, Sam Faulkner, Craig Gedye, James Lynam, Cassandra P. Griffin, Joanne Marsland, Chen Chen Jiang, Hubert Hondermarckinstructions and as previously reported [24]. Cells were treated with AF38469 (400 nM, catalogue number HY-12802, MedChemExpress, Monmouth Junction, NJ, USA), TMZ (50 μM, catalogue number S1237, Selleck Chem, Sapphire

(6) The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor SortilinBioorganic & medicinal chemistry lettersJanuary 1, 2014Schrøder TJ, Christensen S, Lindberg S, Langgård M, David L, Maltas PJ, Eskildsen J, Jacobsen J, Tagmose L, Simonsen KB, et al.

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AF38469 from MedChemExpress

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AF38469 from MedChemExpress

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