MPP+ iodide from MedChemExpress

Product Specs
ItemMPP+ iodide
CompanyMedChemExpress
Price $41.00Supplier Page View Company Product Page
Catalog NumberHY-W008719
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.94%
FormulaC12H12IN
Research AreaNeurological Disease
TypeChemical
Molecular Weight297.14
Quantity10 mM * 1 mL
Molecule NameMPP+ (iodide)

Add to Compare List

MedChemExpress

1 Deer Park Drive, Suite F

MONMOUTH JUNCTION, NJ 08852

United States

Phone: US Tel: 609-228-6898
US Fax: 609-228-5909
EU Tel: +4686500910

Email: sales@medchemexpress.com
eu.sales@MedChemExpress.com

Company Profile

Website: medchemexpress.com

(1) Uric acid alleviates the inflammatory response in LPS-induced BV2 cells and MPTP-induced PD mice by resisting ferroptosis through the Nrf2 signalling pathwayRedox RepDecember 31, 2026Dongmei Zhou, Tian Xiong, Bing Yang, Fanjie Liu, Xianglai Mo, Ting Chen, Peipei Lu, Xinghuan Liang, Li Li, Yingfen Qin, et al.Probenecid (PBN, Cat. No. HY-B0545), ML385 (Cat. No. HY-100523), MPTP (Cat. No. HY-15608) and MPP+ (Cat. # HY-W008719) were purchased from MedChemExpress (New Jersey, U.S.A.). All antibodies and assay kits are detailed

(2) Circ-find-0001774 Modulates Parkinson's Disease via miR-153-3p: Mechanistic Insights and Therapeutic ImplicationsJ Mol NeurosciMarch 30, 2026Ronglan Zhu, Jie Chen, Tao Song, Yun Yang, Chaoyang Zhou, Zhiping Xie, Min Yuan, Jianzhong Zhangestablish the Parkinson’s disease cell model, MN9D cells were incubated with 100 µmol/L MPP+ iodide (HY-W008719, MCE) for 24 h (Lang et al. 2020). CCK-8 Cell Proliferation Assay Following treatment for 24 h, 100

(3) Identification of the mitochondria-related gene IRF7 shared by physical exercise and Parkinson's disease and exploration of its potential molecular mechanismsPeerJMarch 26, 2026Xinyi Hu, Zhiliang Cai, Feiran Zhou, Siliang Chen, Ping Li, Siyi Jin, Songyao Lan, Xiaoyan Du, Rui Xingdifferentiation. Next, cells were treated with 20–100 μM MPP+ (1-methyl-4-phenylpyridinium cation, MedChemExpress, HY-W008719) at a concentration for 3 days. Lipid peroxidation analysis using C11-BODIPY 1 × 105 cells were inoculated

(4) Targeting the bile acid receptor TGR5 with Gentiopicroside to activate Nrf2 antioxidant signaling and mitigate Parkinson’s disease in an MPTP mouse modelJournal of Advanced ResearchFebruary 1, 2026Ying Gao, Xiuling Tang, Jingyue Yao, Ting Sun, Yue Chen, Caiyan Cheng, Jingcheng Yang, Bao Wang, An Liu, Le Yang, et al.CO2. Following a 6 h pretreatment with GPS, cells were exposed to 1-methyl-4-phenylpyridinium (MPP+, HY-W008719, MCE) for 24 h. For transfection, the mixture of small interfering RNA (siRNA) and X-tremeGENE™ siRNA transfection reagent

(5) Neuroprotective Effects of Time‐Restricted Feeding Combined With Different Protein Sources in MPTP‐Induced Parkinson's Disease Mice Model and Its Modulatory Impact on Gut Microbiota MetabolismAdvanced ScienceJanuary 26, 2026Ting Li, Jian Wu, Sheng‐Yang Zhou, Ming‐An Li, Li‐Ping Zhao, Ao Wang, Yi‐Zhi Song, Wen‐Yan Huang, Lu‐Lu Tan, Chen‐Meng Qiao, et al.induce a neuron‐like phenotype before treatment. Differentiated cells were then exposed to 500 µM MPP+ (HY‐W008719, MedChemExpress, China) with or without 5 mM BCAAs for 24 h to evaluate the impact of elevated BCAAs

(6) Zhigancao decoction alleviates Parkinson’s disease via inhibiting TNF/NF-κB and Ras/ERK-mediated neuroinflammation and apoptosisiScienceJanuary 16, 2026Jiakang Zhang, Xinlang Yu, Yuan Fang, Wenshan Li, Qi Cui, Xiaoyu Liu, Yanjie Jiang, Yin Zhang, Chengcheng Xu, Xin Sun, et al.in vitro neurotoxicity, SH-SY5Y cells were exposed to 1-methyl-4-phenylpyridinium (MPP+; MCE, China, HY-W008719, 99.94%). The cells were maintained in high-glucose Dulbecco’s Modified Eagle’s Medium supplemented

(7) Transcranial direct current stimulation exerts neuroprotective effects in Parkinson’s disease by restoring Mlst8-mediated autophagic homeostasisJournal of Translational MedicineJanuary 3, 2026Zekun Tian, Chao Long, Juan Wei, Yan Jiang, Yi Liu, Zhenyu Liu, Manxia Li, Keshu Yang, Chengbiao Ding, Tsung-Hsun Hsieh, et al.differentiated Pheochromocytoma cells 12 (PC-12, Fuheng Biotechnology, FH0414, Shanghai, China) via MPP+ (MCE, HY-W008719). When the cells reached 60–70% confluency, they were treated with 0.5, 1.0, or 1.5 mM MPP+ for 24 h

(8) UBC9 mediates mitophagy to attenuate oxidative stress by regulating SUMOylation of PINK1 in the Parkinson’s disease progressionCell Biology and ToxicologyDecember 6, 2025Jian Liu, Ge Jia, Yu Zhou, Junmei Zhang, Yanjin Wang, Yuxiang CaiUSA) and penicillin/streptomycin (Gibco, USA) with 5% CO2 at 37 °C. Cells were subjected to 2 mM MPP+ (HY-W008719, MedChemExpress) for 24 h to construct an in vitro PD cells model. Following MPP+ stimulation, cells

(9) Multi-Omics Analysis Reveals Distinct Lipid Remodelling and Mitochondrial Stress in SH-SY5Y Cells Modelling Parkinson's DiseaseMetabolitesDecember 4, 2025Shu Wang, Zhen Ni, Gaoge Wang, Jingzheng Zhang, Yunfu Tan, Enliang Hong, Yunting Wang, Huan Chen, Hongwei Hou, Qingyuan Hu6-hydroxydopamine (6-OHDA; Sigma-Aldrich, Darmstadt, Germany, H4381) or 1-methyl-4-phenylpyridinium (MPP+; MCE, HY-W008719). 2.2. Cell Viability and Functional Assays 2.2.1. Cell Viability Assay To determine the appropriate

(10) MFN2-a multifaceted guardian against Parkinson’s pathophysiology: mitochondria, ferroptosis, inflammation and oxidative stressFrontiers in Aging NeuroscienceSeptember 16, 2025Yan Cheng, Hongjiang Zhai, Yong Liu, Yunzhou Yang, Bo Fang, Mingxiang Song, Xiuqin Wang, Ping Zhongtreating SH-SY5Y cells (iCell-h187, iCell Bioscience Inc., China) with 1-methyl-4-phenylpyridinium (MPP+) (HY-W008719, MCE, USA). To further explore the function of MFN2 gene in SH-SY5Y cells, pcDNA3.1-EGFP overexpression

(11) The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's diseaseNeural regeneration researchAugust 1, 2025Zhou S, Li T, Zhang W, Wu J, Hong H, Quan W, Qiao X, Cui C, Qiao C, Zhao W, et al.a density of 5 × 105 cells/mL, then exposed to 0, 10, 20, or 50 μM MPP+ (MCE, Shanghai, China, Cat# HY-W008719) for 24 hours. To investigate the potential neuroprotective effects of cGAS or STING inhibition, cells

(12) Mitochondrial dysfunction-mediated metabolic remodeling of TCA cycle promotes Parkinson's disease through inhibition of H3K4me3 demethylationCell Death DiscovJuly 29, 2025Xiaoyuan Zhang, Fali Zhang, Yue Zeng, Aiying Li, Jiamao Yan, Pei Li, Kexin Qin, Teng Zhang, Jiaojiao Huang, Minghui Zhao, et al.in vitro cell model of PD [16], SH-SY5Y cells were treated for 24 h with 1 μM MPP (MedChemExpress, HY-W008719) and various small molecules purchased from MedChemExpress as follows: 1 μM ZLN005, a potent activator

(13) Endoplasmic Reticulum Stress Inhibition Promotes Mitophagy via Miro1 Reduction to Rescue Mitochondrial Dysfunction and Protect Dopamine Neurons in Parkinson's DiseaseCell Mol NeurobiolMay 29, 2025Yuqi Wen, Zheng Han, Bao Wang, Chenxi Feng, Xvshen Ding, Yangni Li, Yan Lv, Xuelian Wang, Li Gao1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (#HY-15608), 1-methyl-4-phenyl-pyridine (MPP+) (#HY-W008719), Mito-Q (#HY-100116A), Cell Counting Kit-8 (#HY-K0301), Dihydroethidium (DHE) (#HY-D0079), MitoSOX Red

(14) Extracellular Vesicles Derived from FGF2-Primed Astrocytes Against Mitochondrial and Synaptic Toxicities in Parkinson's DiseaseInt J NanomedicineApril 13, 2025Xiaomin Wen, Wanjun Cao, Hui Ding, Andi Chen, Zhichuan Sun, Yazhou Wang, Ye Xi, Shengxi WuThe microglia-conditioned medium (MCM) treated with LPS (100 ng/mL, Sigma, Germany) or MPP+ (100 nM, HY-W008719, MCE, USA) was collected and followed by filtration through a 0.22 filter membrane, then applied to

(15) Extracellular Vesicles Derived from FGF2-Primed Astrocytes Against Mitochondrial and Synaptic Toxicities in Parkinson’s DiseaseInt J NanomedicineApril 13, 2025Xiaomin Wen, Wanjun Cao, Hui Ding, Andi Chen, Zhichuan Sun, Yazhou Wang, Ye Xi, Shengxi WuThe microglia-conditioned medium (MCM) treated with LPS (100 ng/mL, Sigma, Germany) or MPP+ (100 nM, HY-W008719, MCE, USA) was collected and followed by filtration through a 0.22 filter membrane, then applied to

(16) Genetically modified E. Coli secreting melanin (E.melanin) activates the astrocytic PSAP-GPR37L1 pathway and mitigates the pathogenesis of Parkinson's diseaseJournal of nanobiotechnologyNovember 10, 2024Kong W, Liu Y, Ai P, Bi Y, Wei C, Guo X, Cai Z, Gao G, Hu P, Zheng J, et al.plate at a density of approximately 50,000 cells per well. Following 24 h of culture with MPP+ (MCE, HY-W008719), melanin exosomes were added, and the cultivation was continued for another 24 h. Measure the absorbance

(17) Artemisinin exerts a protective effect in the MPTP mouse model of Parkinson's disease by inhibiting microglial activation via the TLR4/Myd88/NF‐KB pathwayCNS Neuroscience & TherapeuticsApril 1, 2023Jing Lv, Jing Zhu, Peihan Wang, Tongyu Liu, Jiang Yuan, Huan Yin, Yiran Lan, Qiang Sun, Zhifeng Zhang, Guoda Ding, et al.BV‐2 cells in the artemisinin treatment group were incubated with 1 μM MPP+ (dissolved in DMEM, MCE, HY‐W008719) for 24 h after treatment with 5 μM artemisinin for 2 h. BV‐2 cells in the TLR4 activator treatment

(18) Mitochondrial calcium dysfunction contributes to autophagic cell death induced by MPP⁺ via AMPK pathwayBiochemical and biophysical research communicationsFebruary 5, 2019Zhao M, Chen J, Mao K, She H, Ren Y, Gui C, Wu X, Zou F, Li W.

(19) Methyl-4-phenylpyridinium (MPP+) differentially affects monoamine release and re-uptake in murine embryonic stem cell-derived dopaminergic and serotonergic neuronsMolecular and cellular neurosciencesSeptember 1, 2017Martí Y, Matthaeus F, Lau T, Schloss P.

(20) Structure-function analysis of yeast mRNA cap methyltransferase and high-copy suppression of conditional mutants by AdoMet synthase and the ubiquitin conjugating enzyme Cdc34pGeneticsAugust 1, 2000Schwer B, Saha N, Mao X, Chen HW, Shuman S.

Be the First to Write a Review!

MPP+ iodide from MedChemExpress

Description

MedChemExpress

Citations (21)

Reviews

MPP+ iodide from MedChemExpress

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map