TPCA-1 from MedChemExpress

Product Specs
ItemTPCA-1
CompanyMedChemExpress
Price $111.00Supplier Page View Company Product Page
Catalog NumberHY-10074
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.66%
TypeChemical
Molecular Weight279.29
FormulaC₁₂H₁₀FN₃O₂S
Research AreaInflammation/Immunology; Cancer

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(1) Concurrent genetic and non-genetic resistance mechanisms to KRAS inhibition in colorectal cancerCancer CellJuly 13, 2026Salvador Alonso, Kevan Chu, Elizabeth Granowsky, Valeria Saraiba Rabanales, Marie J. Parsons, Himari Gunasinghe, Jinru Shia, Rona Yaeger, Lukas E. Dowalpelisib (MedChemExpress, HY-15244), defactinib (MedChemExpress HY-12289), TPCA-1 (MedChemExpress HY-10074), pexidartinib (MedChemExpress HY-16749), SP600125 (MedChemExpress HY-12041), LY2157299 (MedChemExpress

(2) The MIRO1-BAX Complex Dictates Life and Death at the Mitochondrial GatebioRxivJuly 1, 2026Alva G. Sainz, Chulhwan S. Kwak, Kwang Bog Cho, Sejal A. Sripadanna, Brandon H. Bergsneider, Zoe Zizzo, Aarooran S. Durairaj, Zehui Du, Ian Cooney, Anthony Venida, et al.(HY-B1123, MedChemExpress) at 5 μM, Fludarabine (Flu) (HY-B0069, MedChemExpress) at 200 μM, TPCA-1 (HY-10074, MedChemExpress) at 1 μM, RSL3 (S8155, Selleckchem) at 10 μM, Fer1 (HY-100579, MedChemExpress) at 10

(3) Targeting the ICAM-1/LFA-1 adhesion axis attenuates lethal Crimean-Congo hemorrhagic fever virus infectionCell InsightApril 30, 2026Yajie Liu, Liushuai Li, Kai Liu, Shuo Chen, Fan Wu, Jiang Li, Xinbo Zhou, Zhihong Hu, Wu Zhong, Manli Wang(0, 200, 400, 800 μg/mL, 30 min; BSA, control); and addition of NF-κB inhibitor TPCA-1 (MCE, Cat. No. HY-10074) (0, 5, 10 μM) during HUVECs infection. All other procedures and data analysis were performed as described

(4) IL-17-producing γδ T cells in the tumor microenvironment promote radioresistance in miceJournal of Clinical InvestigationDecember 15, 2025Yue Deng, Xixi Liu, Xiao Yang, Wenwen Wei, Jiacheng Wang, Zheng Yang, Yajie Sun, Yan Hu, Haibo Zhang, Yijun Wang, et al.Wuhan, China). Chemical reagents. STING inhibitor C-176 (Selleck, S6575), NF-κB inhibitor TPCA-1 (MCE, HY-10074), Mouse IL-17A neutralization antibody (BioXCell, BE0173), and Mouse CCL20 neutralization antibody (R&D Systems

(5) IL-17–producing γδ T cells in the tumor microenvironment promote radioresistance in miceJ Clin InvestOctober 7, 2025Yue Deng, Xixi Liu, Xiao Yang, Wenwen Wei, Jiacheng Wang, Zheng Yang, Yajie Sun, Yan Hu, Haibo Zhang, Yijun Wang, et al.Wuhan, China). Chemical reagents. STING inhibitor C-176 (Selleck, S6575), NF-κB inhibitor TPCA-1 (MCE, HY-10074), Mouse IL-17A neutralization antibody (BioXCell, BE0173), and Mouse CCL20 neutralization antibody (R&D Systems

(6) Small round cell sarcoma tumoroid biobank reveals CIC::DUX4 sarcoma vulnerability to MCL-1 inhibitionNature communicationsAugust 21, 2025Ringnalda FCAS, van Son GJF, Verweij LHG, Kim SY, Amo-Addae V, Flucke UE, Hiemcke-Jiwa LS, Langenberg KPS, Bramer JAM, Heimans L, et al.following drugs were used: Bortezomib (#HY-10227), AZD5991 (#HY-101533), Tapotoclax (#HY-101565), S63845 (#HY-10074), MIK665 (#HY-112218), and A − 1210477 (#HY-12468) were all purchased from MedChemExpress. For the validation

(7) Concurrent genetic and non-genetic resistance mechanisms to KRAS inhibition in CRCbioRxivAugust 5, 2025Salvador Alonso, Kevan Chu, Marie J Parsons, Elizabeth Granowsky, Himari Gunasinghe, Jinru Shia, Rona Yaeger, Lukas E. Dowalpelisib (MedChemExpress, HY-15244), defactinib (MedChemExpress HY-12289 ), TPCA-1 (MedChemExpress HY-10074), pexidartinib (MedChemExpress HY-16749), SP600125 (MedChemExpress HY-12041), LY2157299 (MedChemExpress

(8) RIPK1 S213E mutant suppresses RIPK1-dependent cell death by preventing interactions with RIPK3 and CASP8Cell Death DiscovJuly 25, 2025Ning Nan, Hong Hu, Xinxin Zhu, Jia Liu, Feiyang Yuan, Zhijie Li, Huayi Wanglaboratory. Smac mimetic (HY-15989), zVAD.fmk (HY-16658), Poly I:C (HY-107202), TAKi (HY-103490), TPCA-1 (HY-10074), NEC-1 (HY-15760), NSA (HY-100573), AP20187 (HY-13992) were purchased from MCE. CL-hPARP1 antibody

(9) Protein phosphatase 6 activates NF-κB to confer sensitivity to MAPK pathway inhibitors in KRAS - and BRAF -mutant cancer cellsScience SignalingMay 14, 2024Haibo Zhang, Abigail Read, Christophe Cataisson, Howard H. Yang, Wei-Chun Lee, Benjamin E. Turk, Stuart H. Yuspa, Ji Luowas from Millipore-Sigma (Cat. # 401481), and IKK2 inhibitor TPCA-1 was from MedChemExpress (Cat. # HY-10074), MK2206 was from MedChemExpress (Cat. # HY-10358). Compounds were stored as high concentration DMSO

(10) The Toxoplasma effector GRA28 promotes parasite dissemination by inducing dendritic cell-like migratory properties in infected macrophagesCell Host & MicrobeNovember 1, 2022Arne L. ten Hoeve, Laurence Braun, Matias E. Rodriguez, Gabriela C. Olivera, Alexandre Bougdour, Lucid Belmudes, Yohann Couté, Jeroen P. J. Saeij, Mohamed-Ali Hakimi, Antonio BarraganSolution (1000x),eBioscience,Cat# 00–4506-51 TPCA-1 STAT3 and IKK-2 inhibitor,MedChemExpress,Cat# HY-10074 AS1517499 STAT6 inhibitor,MedChemExpress,Cat# HY-100614 CellTracker Orange CMTMR Dye,Thermo Fisher,Cat#

(11) Quantitative analysis of phosphoproteome in necroptosis reveals a role of TRIM28 phosphorylation in promoting necroptosis-induced cytokine productionCell death & diseaseOctober 23, 2021Zu R, Yu Z, Zhao J, Lu X, Liang W, Sun L, Si C, Zhu K, Zhang T, Li G, et al.in this study: TNFα (Novoprotein, C008), 5Z-7-Oxozeaenol (5Z-7) (Sigma-Aldrich, O9890), TPCA-1 (MCE, HY-10074), PH-797804 (MCE, HY-10403), LY2228820 (MCE, HY-13241), MK2i (MCE, HY-12834A), GSK’872 (Calbiochem,

(12) RNA-induced liquid phase separation of SARS-CoV-2 nucleocapsid protein facilitates NF-κB hyper-activation and inflammationSignal transduction and targeted therapyApril 24, 2021Wu Y, Ma L, Cai S, Zhuang Z, Zhao Z, Jin S, Xie W, Zhou L, Zhang L, Zhao J, et al.Doxycycline (D9891), Digitonin (D141), and 1,6-hexanediol (230117) were acquired from Sigma. TPCA-1 (HY-10074), BAY 11-7082 (HY-13453), JSH-23 (HY-13982), and T6167923 (HY-19744) were acquired from MedChemExpress

(13) TPCA-1 is a direct dual inhibitor of STAT3 and NF-κB and regresses mutant EGFR-associated human non-small cell lung cancersMolecular cancer therapeuticsMarch 1, 2014Nan J, Du Y, Chen X, Bai Q, Wang Y, Zhang X, Zhu N, Zhang J, Hou J, Wang Q, et al.

(14) IKK-2 inhibitor TPCA-1 represses nasal epithelial inflammation in vitroRhinologyJune 1, 2011Sachse F, Becker K, Basel TJ, Weiss D, Rudack C.

(15) Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and antigen-induced T cell ProliferationThe Journal of pharmacology and experimental therapeuticsJanuary 1, 2005Podolin PL, Callahan JF, Bolognese BJ, Li YH, Carlson K, Davis TG, Mellor GW, Evans C, Roshak AK.

(16) Convergence of perturbation expansions around nonstandard mean fieldsPhysical review. A, Atomic, molecular, and optical physicsJuly 1, 1990Dietz K, Hess BA.

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TPCA-1 from MedChemExpress

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TPCA-1 from MedChemExpress

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