SMCC-DM1 from MedChemExpress | Biocompare.com

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SMCC-DM1

Description

SMCC-DM1 (DM1-SMCC) is a agent-linker conjugate composed of a potent microtubule-disrupting agent DM1 and a linker SMCC to make antibody agent conjugate (ADC)

Product Specs
ItemSMCC-DM1
CompanyMedChemExpress
Price $120.00Supplier Page View Company Product Page
Catalog NumberHY-101070
Quantity1 mg
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.23%
TypeChemical
Molecular Weight1072.61
FormulaC₅₁H₆₆ClN₅O₁₆S
Research AreaCancer

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(1) A Toxin-Conjugated Recombinant Protein Targeting gp120 and gp41 for Inactivating HIV-1 Virions and Killing Latency-Reversing Agent-Reactivated Latent CellsmBioFebruary 22, 2022Wang X, Xu W, Liu Z, Wu Y, Wang Q, Cao M, Ying T, He N, Lu L, Jiang S.report, the tubulin inhibitor DM1 containing linker SMCC was purchased from MedChemExpress (Cat. No.: HY-101070, Molecule weight: 1072.61 Da) and coupled with antibodies or proteins by lysine reaction (43–45). Briefly,

(2) Investigating the Impact of Sample Preparation on Mass Spectrometry-Based Drug-To-Antibody Ratio Determination for Cysteine- and Lysine-Linked Antibody–Drug ConjugatesAntibodies (Basel)September 8, 2020Malin Källsten, Rafael Hartmann, Lucia Kovac, Fredrik Lehmann, Sara Bergström Lind, Jonas BergquistGermany N-succinimidyl 4-(maleimidomethyl)cyclohexanecarboxylate (SMCC)-DM1 (abbreviated DM1, and # HY-101070, CAS 1228105–51–8 was purchased from MedChemExpress, NJ, USA. (abbreviated DM1, #and HY-101070, CAS

(3) Site-specific and hydrophilic ADCs through disulfide-bridged linker and branched PEGBioorganic & medicinal chemistry lettersMay 1, 2018Shao S, Tsai MH, Lu J, Yu T, Jin J, Xiao D, Jiang H, Han M, Wang M, Wang J.

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