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Protein Biochemistry
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(Rac)-NSC305787 hydrochloride
(Rac)-NSC305787 hydrochloride from MedChemExpress
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Citations:
(5)
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(Rac)-NSC305787 hydrochloride
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Description
NSC305787 hydrochloride is an inhibitor of
ezrin
with a
K
d
of 5.85 µM, inhibits the phosphorylation of ezrin caused by PKCΙ with an
IC
50
of 8.3 µM, has antitumor activity
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
(Rac)-NSC305787 hydrochloride
Company
MedChemExpress
Price
$462.00
Supplier Page
View Company Product Page
Catalog Number
HY-18931A
Quantity
10 mM * 1 mL
Applications
Bioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity
98.18%
Type
Chemical
Molecular Weight
481.89
Formula
C₂₅H₃₁Cl₃N₂O
Research Area
Cancer
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MedChemExpress
1 Deer Park Drive, Suite F
MONMOUTH JUNCTION
,
NJ
08852
United States
Phone
: US Tel: 609-228-6898
US Fax: 609-228-5909
EU Tel: +4686500910
Email: sales@medchemexpress.com
eu.sales@MedChemExpress.com
Company Profile
Website:
medchemexpress.com
Citations (5)
(1)
ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling
Advanced Science
March 1, 2026
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang,
et al.
humidified incubator maintained at 37°C with 5% CO2. 4.2 Chemicals and Reagents NSC305787 (
MCE
, #
HY‐18931A
) (dissolved in DMSO, sonicated for 5 min to make a 10 mm stock solution, aliquoted and stored at −80°C,
(2)
The chloride intracellular channel 1 (CLIC1) is essential for microglial morphodynamics and neuroinflammation
Sci Adv
October 24, 2025
Ali Rifat, Tom Bickel, Patricia Kreis, Thorsten Trimbuch, Julia Onken, Andranik Ivanov, Giulia Albertini, Dieter Beule, Michele Mazzanti, Harpreet Singh,
et al.
CNS disease
. MATERIALS AND METHODS Compounds IAA-94 (I117, Sigma-Aldrich), NSC-305787 hydrochloride (
HY-18931A
,
MedChemExpress
), NSC-23766 hydrochloride (
HY-15723A
,
MedChemExpress
), A9C (10449010, Thermo Fisher
(3)
CD44/ERM/F-actin complex mediates targeted nuclear degranulation and excessive neutrophil extracellular trap formation during sepsis
Journal of cellular and molecular medicine
April 1, 2022
Shao Y, Li L, Liu L, Yang Y, Huang J, Ji D, Zhou Y, Chen Y, Zhu Z, Sun B.
Wherever indicated, cells were preincubated with an ERM phosphorylation
inhibitor
(P‐ERMi) at 10 μM (
MCE
,
HY‐18931A
) or an importin‐β
inhibitor
(Importini) at 30 μM (
MCE
,
HY‐101091
) for 30 min before stimulation. 2.6
(4)
Ezrin Inhibition Up-regulates Stress Response Gene Expression
The Journal of biological chemistry
June 17, 2016
Çelik H, Bulut G, Han J, Graham GT, Minas TZ, Conn EJ, Hong SH, Pauly GT, Hayran M, Li X,
et al
.
(5)
Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells
Oncogene
January 19, 2012
Bulut G, Hong SH, Chen K, Beauchamp EM, Rahim S, Kosturko GW, Glasgow E, Dakshanamurthy S, Lee HS, Daar I,
et al
.
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(Rac)-NSC305787 hydrochloride from MedChemExpress
Supplier Page
View Company Product Page
$462.00
Product Specs
Company Info
Citations
Reviews
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