Intoplicine from MedChemExpress | Biocompare.com

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Intoplicine

Description

Intoplicine (RP 60475), an antitumor derivative in the 7H-benzo[e]pyrido[4,3-b]indole series, is a DNA topoisomerase I and II inhibitor. Intoplicine strongly binds DNA (K_A = 2 x 10⁵ /M) and thereby increases the length of linear DNA

Product Specs
ItemIntoplicine
CompanyMedChemExpress
Price $800.00Supplier Page View Company Product Page
Catalog NumberHY-101647
Quantity5 mg
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity98.36%
TypeChemical
Molecular Weight348.44
FormulaC₂₁H₂₄N₄O
Research AreaCancer

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(1) Activity of intoplicine (RP60475), a new DNA topoisomerase I and II inhibitor, against human tumor colony-forming units in vitroJournal of the National Cancer InstituteJanuary 5, 1994Eckardt JR, Burris HA 3rd, Kuhn JG, Bissery MC, Klink-Alakl M, Clark GM, Von Hoff DD.

(2) Antitumor activity of intoplicine (RP 60475, NSC 645008), a new benzo-pyrido-indole: evaluation against solid tumors and leukemias in miceInvestigational new drugsNovember 1, 1993Bissery MC, Nguyen CH, Bisagni E, Vrignaud P, Lavelle F.

(3) Molecular and cellular interactions between intoplicine, DNA, and topoisomerase II studied by surface-enhanced Raman scattering spectroscopyCancer researchOctober 15, 1993Morjani H, Riou JF, Nabiev I, Lavelle F, Manfait M.

(4) The effect of thermic stress on the somatic reaction of rage and on rapid circling turns, in the catArchives internationales de physiologie et de biochimieOctober 1, 1976Giammanco S, Paderni MA, Carollo A.

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