ML216 from MedChemExpress

Description

ML216 (CID-49852229) is a potent, selective and cell permeable inhibitor of the DNA unwinding activity of BLM helicase with IC₅₀s of 2.98 µM and 0.97 µM for BLM^full-length and BLM^636-1298, respectively. ML216 inhibits ssDNA-dependent ATPase activity of BLM with a K_i of 1.76 µM. Antitumor avtivity

Product Specs
ItemML216
CompanyMedChemExpress
Price $80.00Supplier Page View Company Product Page
Catalog NumberHY-12342
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.89%
TypeChemical
Molecular Weight383.32
FormulaC₁₅H₉F₄N₅OS
Research AreaCancer

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(1) ML216 Alleviates Age-Related Cardiac Fibrosis by Suppressing TGF-β1 Signaling PathwayInt J Mol SciApril 10, 2026Wenbin Liu, Feng Cui, Xiaodan Huang, Na Liang, Jun Liand Methods 4.1. Chemical Reagents and Antibodies Isoproterenol hydrochloride (HY-B0468), ML216 (HY-12342) and TGF-β1 protein (HY-P7117) were purchased from MCE (Monmouth Junction, NJ, USA). Wheat Germ Agglutinin

(2) ML216 Prevents DNA Damage-Induced Senescence by Modulating DBC1-BLM InteractionCellsDecember 29, 2022Cui F, Han X, Zhang X, Wang S, Liang N, Tan Q, Sha W, Li J.staurosporine (62996-74-1) were purchased from MCE (Middlesex, NJ, USA). ML216 was purchased from MCE (HY-12342) and Selleck (S0469, Houston, TX, USA). Hydroxyurea (V900323) and etoposide (E1383) were purchased from

(3) A new development in DNA repair modulation: discovery of a BLM helicase inhibitorCell cycle (Georgetown, Tex.)March 1, 2013Banerjee T, Aggarwal M, Brosh RM Jr.

(4) A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cellsChemistry & biologyJanuary 24, 2013Nguyen GH, Dexheimer TS, Rosenthal AS, Chu WK, Singh DK, Mosedale G, Bachrati CZ, Schultz L, Sakurai M, Savitsky P, et al.

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ML216 from MedChemExpress

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