Rucaparib monocamsylate from MedChemExpress

Description

Rucaparib (AG014699) monocamsylate is an orally active, potent inhibitor of PARP proteins (PARP-1, PARP-2 and PARP-3) with a K_i of 1.4 nM for PARP1. Rucaparib monocamsylate is a modest hexose-6-phosphate dehydrogenase (H6PD) inhibitor. Rucaparib monocamsylate has the potential for castration-resistant prostate cancer (CRPC) research

Product Specs
ItemRucaparib monocamsylate
CompanyMedChemExpress
Price $86.00Supplier Page View Company Product Page
Catalog NumberHY-102003
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.91%
TypeChemical
Molecular Weight555.66
Molecule NameRucaparib (monocamsylate)
FormulaC29H34FN3O5S
Research AreaCancer

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(1) Hexose-6-phosphate dehydrogenase blockade reverses prostate cancer drug resistance in xenograft models by glucocorticoid inactivationScience translational medicineMay 26, 2021Li J, Berk M, Alyamani M, Sabharwal N, Goins C, Alvarado J, Baratchian M, Zhu Z, Stauffer S, Klein EA, et al.

(2) Rucaparib: A Review in Ovarian CancerTargeted oncologyApril 1, 2019Shirley M.

(3) Tumour cell retention of rucaparib, sustained PARP inhibition and efficacy of weekly as well as daily schedulesBritish journal of cancerApril 15, 2014Murray J, Thomas H, Berry P, Kyle S, Patterson M, Jones C, Los G, Hostomsky Z, Plummer ER, Boddy AV, et al.

(4) NF-κB mediates radio-sensitization by the PARP-1 inhibitor, AG-014699OncogeneJanuary 12, 2012Hunter JE, Willmore E, Irving JA, Hostomsky Z, Veuger SJ, Durkacz BW.

(5) Inhibition of poly(ADP-ribose) polymerase-1 enhances temozolomide and topotecan activity against childhood neuroblastomaClinical cancer research : an official journal of the American Association for Cancer ResearchFebruary 15, 2009Daniel RA, Rozanska AL, Thomas HD, Mulligan EA, Drew Y, Castelbuono DJ, Hostomsky Z, Plummer ER, Boddy AV, Tweddle DA, et al.

(6) Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trialMolecular cancer therapeuticsMarch 1, 2007Thomas HD, Calabrese CR, Batey MA, Canan S, Hostomsky Z, Kyle S, Maegley KA, Newell DR, Skalitzky D, Wang LZ, et al.

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Rucaparib monocamsylate from MedChemExpress

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Rucaparib monocamsylate from MedChemExpress

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