ADAMTS-5 Inhibitor from MedChemExpress | Biocompare.com

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ADAMTS-5 Inhibitor

Description

ADAMTS-5 Inhibitor is a potent ADAMTS-5 (aggrecanase-2) inhibitor, with an IC₅₀ of 1.1 µM. ADAMTS-5 Inhibitor shows >40-fold functional selectivity over ADAMTS-4 (aggrecanase-1)

Product Specs
ItemADAMTS-5 Inhibitor
CompanyMedChemExpress
Price $165.00Supplier Page View Company Product Page
Catalog NumberHY-114996
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.59%
FormulaC16H11ClF3N3OS3
Research AreaInflammation/Immunology
TypeChemical
Molecular Weight449.92
Quantity10 mM * 1 mL
Molecule NameADAMTS-5 Inhibitor

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(1) Adamts5 (aggrecanase-2) is widely expressed in the mouse musculoskeletal system and is induced in specific regions of knee joint explants by inflammatory cytokinesJournal of orthopaedic research : official publication of the Orthopaedic Research SocietyFebruary 1, 2012Wylie JD, Ho JC, Singh S, McCulloch DR, Apte SS.

(2) 5-((1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5Bioorganic & medicinal chemistry lettersMarch 1, 2007Gilbert AM, Bursavich MG, Lombardi S, Georgiadis KE, Reifenberg E, Flannery CR, Morris EA.

(3) Requirement for Ethylene Synthesis and Action during Relief of Thermoinhibition of Lettuce Seed Germination by Combinations of Gibberellic Acid, Kinetin, and Carbon DioxidePlant physiologyAugust 1, 1986Saini HS, Consolacion ED, Bassi PK, Spencer MS.

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