RO4929097 from MedChemExpress

Product Specs
ItemRO4929097
CompanyMedChemExpress
Price $114.00Supplier Page View Company Product Page
Catalog NumberHY-11102
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.01%
TypeChemical
Molecular Weight469.4
FormulaC₂₂H₂₀F₅N₃O₃
Research AreaNeurological Disease; Cancer

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(1) Non-canonical NOTCH1 signaling regulates ferroptosis vulnerability in dormant lung cancer cells with stable resistanceCell death & diseaseDecember 26, 2025Huang H, Chai Y, Wu X, Wang S, Li B, Wang Y, Zheng W, Wu Y, Meng D, Wang H, et al.tumors. Materials and methods Chemicals The chemicals and compounds cisplatin (#HY-17394), RO4929097 (#HY-11102), PF-03084014 (#HY-15185B), Ferrostain-1 (#HY100579), Z-VAD-FMK (#HY16658B), FSEN1 (#HY-153629), BAI1

(2) Apelin signaling acts as a molecular switch between endothelial and hematopoietic stem cell fatesEMBO ReportsDecember 16, 2025Jean Eberlein, Nadja Groos, Navina Shrestha Duwal, Wade W Sugden, Trista E North, Christian S M Helkerreagents","Chemicals, enzymes and other reagents","Chemicals, enzymes and other reagents" RO4929097,MedChemExpress,HY- 11102 DMH-1,Calbiochem,203646 LiCl,Sigma-Aldrich,L7026 Purmorphamine,MedChemExpress,HY -15108 Software,Software,Software GraphPad

(3) CLDN4 palmitoylation promotes hepatic-to-biliary lineage transition and lenvatinib resistance in hepatocellular carcinomaCell Rep MedJuly 15, 2025Minghao Xu, Yimin Zheng, Junbo Chen, Chao Gao, Miao Zhu, Aying Ma, Bugang Liang, Wenxin Xu, Jia Fan, Haibo Zhou, et al.beads,MCE,HY-K0202 2-Bromopalmitate,MCE,HY-111770 MG132,MCE,HY-13259 Amiloride,MCE,HY-B0285 Chloroquine,MCE,HY-17589A RO4929097,MCE,HY-11102 Salvianolic acid B,MCE,HY-N1362 Cycloheximide,MCE,HY-12320 TRIzol reagent,Thermo Fisher,15596026 Puromycin,Beyotime,ST551 N-ethylmaleimide,Sigma,E3876 Hydroxylamine,Sigma,467804 Biotin

(4) Chronic cerebral hypoperfusion induces venous dysfunction via EPAS1 regulation in miceNat CommunJuly 8, 2025Vanessa Kristina Wazny, Aparna Mahadevan, Nhi Nguyen, Hannah Wee, Ashwati Vipin, Tammy Lam, Kai Yi Tay, Jia-Xiang See, Gurveen Sandhu, Yi Jin Leow, et al.used. For pre-vein induction, CDM comprises 2 μM SB505124, 250 nM DMH1, 2 μM RO4929097 (MedChemExpress, HY-11102), 100 ng/ml VEGF, 1 μM XAV939 and 200 μg/ml L-Ascorbic acid 2-phosphate sesquimagnesium. For pre-vein

(5) Inhibiting HMGCR represses stemness and metastasis of hepatocellular carcinoma via Hedgehog signalingGenes & DiseasesSeptember 1, 2024Zhirong Zhang, Jiayao Yang, Rui Liu, Jing Ma, Kai Wang, Xiaojun Wang, Ni Tangh; SB431542 (S1067, Selleck, TX, USA), 10 μM, 36 h; XAV-939 (HY-15147, MCE), 10 μM, 36 h; RO4929097 (HY-11102, MCE), 10 μM, 36 h; vismodegib (HY-10440, MCE), 10 μM, 36 h. Adenovirus production The full-length

(6) Apelin signaling dependent endocardial protrusions promote cardiac trabeculation in zebrafishElifeFebruary 28, 2022Jialing Qi, Annegret Rittershaus, Rashmi Priya, Shivani Mansingh, Didier YR Stainier, Christian SM Helkerinhibitor PD0325901,Sigma,Cat# PZ0162,(1 µM) "Chemical compound, drug",RO 4929097,MedChemExpress,Cat# HY-11102,(1 µM) Other,DAPI,Sigma,Cat# D9542,(1 μg/ml) Commercial assay or kit,Alexa Fluor 568 Phalloidin,Thermo Fisher Scientific

(7) Apelin signaling dependent endocardial protrusions promote cardiac trabeculation in zebrafisheLifeFebruary 28, 2022Jialing Qi, Annegret Rittershaus, Rashmi Priya, Shivani Mansingh, Didier Y R Stainier, Christian S M Helkerinhibitor PD0325901,Sigma,Cat# PZ0162,(1 µM) "Chemical compound, drug",RO 4929097,MedChemExpress,Cat# HY-11102,(1 µM) Other,DAPI,Sigma,Cat# D9542,(1 μg/ml) Commercial assay or kit,Alexa Fluor 568 Phalloidin,Thermo Fisher Scientific

(8) Alveolar progenitor differentiation and lactation depends on paracrine inhibition of notch via ROBO1/CTNNB1/JAG1Development (Cambridge, England)November 1, 2021Cazares O, Chatterjee S, Lee P, Strietzel C, Bubolz JW, Harburg G, Howard J, Katzman S, Sanford J, Hinck L.Saccharomyces cerevisiae ACT1 gene, provided in the Cut&Run kit. In vivo GSI GSI RO4929097 (MedchemExpress, HY-11102) was orally administered at 10 mg/kg body weight for 5 days as previously described (Regan et al., 2013).

(9) Pre-clinical studies of Notch signaling inhibitor RO4929097 in inflammatory breast cancer cellsBreast cancer research and treatmentJuly 1, 2012Debeb BG, Cohen EN, Boley K, Freiter EM, Li L, Robertson FM, Reuben JM, Cristofanilli M, Buchholz TA, Woodward WA.

(10) The novel gamma secretase inhibitor RO4929097 reduces the tumor initiating potential of melanomaPloS oneJanuary 1, 2011Huynh C, Poliseno L, Segura MF, Medicherla R, Haimovic A, Menendez S, Shang S, Pavlick A, Shao Y, Darvishian F, et al.

(11) Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic propertiesCancer researchOctober 1, 2009Luistro L, He W, Smith M, Packman K, Vilenchik M, Carvajal D, Roberts J, Cai J, Berkofsky-Fessler W, Hilton H, et al.

(12) Notch3 is involved in the proliferation of renal cancer cells via regulation of cell cycle progression and HIF-2αOncology lettersJanuary 1, 0001"Han Q, Han F, Fan Y, Lian B, Xiao J, Sun W, Han D, Kou H, Li C, Wu B."HyClone; Cytiva), respectively. 786‑O and ACHN cells were treated with or without RO4929097 (cat. no. HY‑11102; MCE), and were cultured under normoxic (21% O2, 37˚C and 5% CO2) or hypoxic (2% O2, 37˚C and 5% CO2)

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RO4929097 from MedChemExpress

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RO4929097 from MedChemExpress

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